Effects of Alkaline-Reduced Water on Gastrointestinal Diseases

Living a healthy lifestyle is the most important need in the world today. However, oxidative stress (OS) is caused by several stress-inducing factors such as smoking, alcohol consumption, chronic diseases, and inflammatory responses, oxygen-free radicals are produced in excess and can damage major organs in the body. This phenomenon has been implicated in the pathogenesis of several gastrointestinal (GI) diseases, including gastritis, constipation, and inflammatory bowel diseases, which include Crohn’s disease, ulcerative colitis, functional dyspepsia, acid reflux, diverticular disease, and irritable bowel syndrome. In this review article, we provide a brief overview of the role of OS in the pathogenesis of GI disorders. Additionally, we discuss the therapeutic role of alkaline-reduced water (ARW) on GI diseases and existing studies on ARW related to GI diseases. Furthermore, we believe that findings from this review article will enhance the knowledge of the readers on the role of ARW on OS and inflammation-based GI diseases.

Examine the Frequency of Postnatal Depression in Mothers having Malnourished Infants

Background: Healthy child development is dependent on a mentally and physically healthy mother. Depressions in mother can adversely affect their offspring healthy growth. Aim: To estimate the frequency of post-natal depression in mothers having malnourished infants. Place and duration of study: Department of Psychiatry, Balochistan Institute of Psychiatry & Behavioral Sciences, Qeutta from 1st January 2020 to 31st December 2020. Methodology: In this case control study 250 mothers (125 were malnourished infants or toddlers mothers and other 125 from healthy weight infants/toddlers mothers) were interviewed to assess their depressional state. Their stress inducing factors, age and other clinical comorbidities were also documented. Results: Mean mother age of malnourished infants/toddlers was 28.1±6.6 years in comparison to 27.8±5.2 years of healthy weight infants/toddlers mother’s respectively. Twenty four percent malnourished infant/toddlers’ mothers were single parent. Un-employed spouse of mothers to malnourished infant/toddlers were found at higher frequency (51.06%) than of healthy infant/toddlers (23.4%).The frequency of post-natal depression among mothers of malnourished infants/toddlers was observed in 57.6% cases Conclusion: Out of total 57.5% mothers of malnourished children suffering from post-natal depression there are 15.2% to 9.6% those having moderate to highly moderate post-natal depression. Keywords: Post-natal depression, Malnourish, Infants, Toddlers

Factors Inducing Literature Anxiety for Students Studying Literature in English

Students have been plagued with various types of anxieties in the educational context, hence we propose to introduce the concept of literature anxiety in this study. This study investigates the possible factors inducing literature anxiety from the perspectives of university students studying Literature in English at tertiary level, and records their emotional experiences during their learning encounters with Literature in English. The study also presents how these students make sense of their Literature in English learning and how their knowledge and perceptions of Literature in English have influenced or affected their experience of literature anxiety. SPSS analysis of the data procured through the Literature Anxiety Scale (LITAS) provided evidence concerning students’ literature anxiety and the factors they perceive inducing literature anxiety for them. The literature anxiety-inducing factors were identified as situational, dispositional, and environmental factors. The findings obtained showed that students’ literature anxiety does debilitate their studying of Literature in English. The implications are that educators should teach more attentively and be sensitized to learners’ possible experience of anxiety.

Bipolar Patients and Bullous Pemphigoid after Risperidone Long-Acting Injectable: A Case Report and a Review of the Literature

Neuropsychiatric disorders are found to be associated with bullous pemphigoid (BP), an autoimmune subepidermal blistering disease. Antipsychotics have emerged as possible inducing factors of BP. However, large sample studies concerning BP associated with antipsychotics, as well as with specific mental disorders, are still lacking. Our review retrieved a few clinical studies and case reports on the topic, producing controversial results. We report for the first time a bipolar patient case presenting BP following five-month therapy with risperidone long-acting injectable (LAI). We hypothesize that the dermatological event is associated with the medication administered. The issue emerged during psychiatric consultation and was confirmed by histological examination, direct and indirect immunofluorescence studies, plus positive plasma and cutaneous BP180 and BP230 IgG. Neurodegeneration or neuroinflammation might represent a primary process leading to a cross-reactive immune response between neural and cutaneous antigens and contributing to self-tolerance failure. Furthermore, the time sequence of the shared biological mechanisms leading to clinical manifestations of the neuropsychiatric disorder and BP remains undefined. BP comorbid with bipolar disorder might occasionally represent a serious health risk and affect patients’ physical and psychosocial quality of life. Thus, clinicians treating psychiatric patients should consider BP as a possible adverse effect of psychotropic medications.

Stress Inducing Factors and Its Effect on Employees Performance among Selected Instituions

Aims: The study examined the relationship between stress inducing factors and employee performance in Michael Imoudu National Institute for Labour Studies (MINILS) and National Directorate of Employment (NDE). Study Design: Cross sectional survey design. Place and Duration of Study: The study was carried out at the Michael Imoudu National Institute for labour studies and National Directorate of Employment (NDE) between December 2019 and September 2020 Methodology: The survey method was employed whilst 400 respondents were purposively selected from the Training department, Planning, Research and Curriculum Development department and Programs department which are the core departments under pressure to deliver all year round in the institutions under study. The questionnaire was the main instrument for data collection. The Pearson Product Moment Correlation was used in analyzing the data. Results: Results show that the most stress inducing factor was pressure to deliver on time because of mode of operations (60%), non-conducive working environment (59%) and being insufficiently skilled for the job (37%). The effects of stress on employee performance include dependence on drugs and alcohol (86%), illness and sickness (75%), fatigue (40%) and irritability (25%). Conclusion: It is recommended that a conducive working environment should be created for employees and that counselors and counseling rooms should be provided by organizations to enable their employees have a safe place to de-stress without fear of stigmatization. Also, training and re-training of employees should be done frequently to improve set skills. This will significantly reduce work stress and enhance performance which will in turn increase organizational productivity.

Role of Brown and Beige Adipose Tissues in Seasonal Adaptation in the Raccoon Dog (Nyctereutes procyonoides)

Brown adipose tissue (BAT) expresses uncoupling protein-1 (UCP1), which enables energy to be exerted towards needed thermogenesis. Beige adipocytes are precursor cells interspersed among white adipose tissue (WAT) that possess similar UCP1 activity and capacity for thermogenesis. The raccoon dog (Nyctereutes procyonoides) is a canid species that utilizes seasonal obesity to survive periods of food shortage in climate zones with cold winters. The potential to recruit a part of the abundant WAT storages as beige adipocytes for UCP1-dependent thermogenesis was investigated in vitro by treating raccoon dog adipocytes with different browning inducing factors. In vivo positron emission tomography/computed tomography (PET/CT) imaging with the glucose analog 18F-FDG showed that BAT was not detected in the adult raccoon dog during the winter season. In addition, UCP1 expression was not changed in response to chronic treatments with browning inducing factors in adipocyte cultures. Our results demonstrated that most likely the raccoon dog endures cold weather without the induction of BAT or recruitment of beige adipocytes for heat production. Its thick fur coat, insulating fat, and muscle shivering seem to provide the adequate heat needed for surviving the winter.

Spatial Differentiation in Risk Perception and its Impact on Travel Decisions

This exploratory study adopts a multi-dimensional approach to research on how travel-related risk perceptions are formed. It looks at risk-inducing factors both from the tourist and the destination perspectives. Using predefined risk characteristics observed in the literature, the study's leading research question asked to what extent these individual risk factors influence tourists' risk perception. A sample of potential German tourists to Israel was used for this exploratory study. Each interviewee was asked to indicate his/her socio-cultural background, travel experience at different spatial levels, risk-taking personality, level of perceiving Israel as a risky destination, and willingness to travel to Israel. Results show that accumulated travel experience does have a bearing on German tourists' willingness to travel to destinations that carry a high risk image but does not affect the perceived level of risk. Using the concept of geo-familiarity, the study discovered that risk perception may not only be developed on a country destination level but may be different based on spatial perception of risk. Based on these results, the study draws several risk-management and marketing strategies.