The Plant microRNA Pathway: The Production and Action Stages

2019 ◽  
pp. 15-39 ◽  
Author(s):  
Joseph L. Pegler ◽  
Christopher P. L. Grof ◽  
Andrew L. Eamens
Keyword(s):  
Plant Microrna ◽  
Microrna Pathway

scholarly journals Nucleo-cytosolic Shuttling of ARGONAUTE1 Prompts a Revised Model of the Plant MicroRNA Pathway

2018 ◽  
Vol 69 (4) ◽  
pp. 709-719.e5 ◽  
Author(s):  
Nicolas G. Bologna ◽  
Raphael Iselin ◽  
Luciano A. Abriata ◽  
Alexis Sarazin ◽  
Nathan Pumplin ◽  
...  
Keyword(s):  
Plant Microrna ◽  
Microrna Pathway

scholarly journals Heme oxygenase-1 retards hepatocellular carcinoma progression through the microRNA pathway

2016 ◽  
Vol 36 (5) ◽  
pp. 2715-2722 ◽  
Author(s):  
Chaoxia Zou ◽  
Chendan Zou ◽  
Wanpeng Cheng ◽  
Qiang Li ◽  
Zhongjing Han ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Heme Oxygenase ◽  
Heme Oxygenase 1 ◽  
Microrna Pathway

scholarly journals Author Correction: nc886 is induced by TGF-β and suppresses the microRNA pathway in ovarian cancer

2018 ◽  
Vol 9 (1) ◽  
Author(s):  
Ji-Hye Ahn ◽  
Hyun-Sung Lee ◽  
Ju-Seog Lee ◽  
Yeon-Su Lee ◽  
Jong-Lyul Park ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Microrna Pathway

scholarly journals Translation regulation of mRNAs by the fragile X family of proteins through the microRNA pathway

RNA Biology ◽  
2009 ◽  
Vol 6 (2) ◽  
pp. 175-178 ◽  
Author(s):  
Anne Cheever ◽  
Stephanie Ceman
Keyword(s):  
Fragile X ◽  
Translation Regulation ◽  
Microrna Pathway

scholarly journals Role of microRNA Pathway in Mental Retardation

2007 ◽  
Vol 7 ◽  
pp. 146-154 ◽  
Author(s):  
Abrar Qurashi ◽  
Shuang Chang ◽  
Peng Jin
Keyword(s):  
Mental Retardation ◽  
Fragile X Syndrome ◽  
Genetic Basis ◽  
Fragile X ◽  
Biological Pathways ◽  
Fragile X Mental Retardation ◽  
Mental Retardation Protein ◽  
Mirna Pathway ◽  
Microrna Pathway

Deficits in cognitive functions lead to mental retardation (MR). Understanding the genetic basis of inherited MR has provided insights into the pathogenesis of MR. Fragile X syndrome is one of the most common forms of inherited MR, caused by the loss of functional Fragile X Mental Retardation Protein (FMRP).MicroRNAs (miRNAs) are endogenous, single-stranded RNAs between 18 and 25 nucleotides in length, which have been implicated in diversified biological pathways. Recent studies have linked the miRNA pathway to fragile X syndrome. Here we review the role of the miRNA pathway in fragile X syndrome and discuss its implication in MR in general.

scholarly journals MicroRNA dilution during oocyte growth disables the microRNA pathway in mammalian oocytes

2020 ◽  
Vol 48 (14) ◽  
pp. 8050-8062
Author(s):  
Shubhangini Kataruka ◽  
Martin Modrak ◽  
Veronika Kinterova ◽  
Radek Malik ◽  
Daniela M Zeitler ◽  
...  
Keyword(s):  
Small Rnas ◽  
Gene Repression ◽  
Biological Processes ◽  
Oocyte Growth ◽  
Mammalian Oocyte ◽  
Mirna Pathway ◽  
Microrna Pathway ◽  
Bovine Oocytes ◽  
Mirna Concentration ◽  
Mirna Abundance

Abstract MicroRNAs (miRNAs) are ubiquitous small RNAs guiding post-transcriptional gene repression in countless biological processes. However, the miRNA pathway in mouse oocytes appears inactive and dispensable for development. We propose that marginalization of the miRNA pathway activity stems from the constraints and adaptations of RNA metabolism elicited by the diluting effects of oocyte growth. We report that miRNAs do not accumulate like mRNAs during the oocyte growth because miRNA turnover has not adapted to it. The most abundant miRNAs total tens of thousands of molecules in growing (∅ 40 μm) and fully grown (∅ 80 μm) oocytes, a number similar to that observed in much smaller fibroblasts. The lack of miRNA accumulation results in a 100-fold lower miRNA concentration in fully grown oocytes than in somatic cells. This brings a knock-down-like effect, where diluted miRNAs engage targets but are not abundant enough for significant repression. Low-miRNA concentrations were observed in rat, hamster, porcine and bovine oocytes, arguing that miRNA inactivity is not mouse-specific but a common mammalian oocyte feature. Injection of 250,000 miRNA molecules was sufficient to restore reporter repression in mouse and porcine oocytes, suggesting that miRNA inactivity comes from low-miRNA abundance and not from some suppressor of the pathway.

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