Ultrasensitive Detection of Circulating Tumor DNA in Lymphoma via Targeted Hybridization Capture and Deep Sequencing of Barcoded Libraries

2019 ◽  
pp. 383-435
Author(s):  
Miguel Alcaide ◽  
Christopher Rushton ◽  
Ryan D. Morin
Keyword(s):  
Deep Sequencing ◽  
Circulating Tumor Dna ◽  
Ultrasensitive Detection ◽  
Hybridization Capture ◽  
Tumor Dna

scholarly journals Clinical relevance of circulating tumor DNA assessed through deep sequencing in patients with metastatic colorectal cancer

2018 ◽  
Vol 8 (1) ◽  
pp. 408-417 ◽  
Author(s):  
Hiroki Osumi ◽  
Eiji Shinozaki ◽  
Yoshinori Takeda ◽  
Takeru Wakatsuki ◽  
Takashi Ichimura ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Metastatic Colorectal Cancer ◽  
Deep Sequencing ◽  
Clinical Relevance ◽  
Circulating Tumor Dna ◽  
Tumor Dna

scholarly journals Genotyping of circulating tumor DNA in cholangiocarcinoma reveals diagnostic and prognostic information

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
T. J. Ettrich ◽  
D. Schwerdel ◽  
A. Dolnik ◽  
F. Beuter ◽  
T. J. Blätte ◽  
...  
Keyword(s):  
Deep Sequencing ◽  
Tumor Tissue ◽  
Circulating Tumor Dna ◽  
Therapeutic Strategies ◽  
Variant Allele Frequency ◽  
Prognostic Information ◽  
Driver Genes ◽  
Tumor Load ◽  
Molecular Landscape ◽  
Tumor Dna

Abstract Diagnosis of Cholangiocarcinoma (CCA) is difficult, thus a noninvasive approach towards (i) assessing and (ii) monitoring the tumor-specific mutational profile is desirable to improve diagnosis and tailor treatment. Tumor tissue and corresponding ctDNA samples were collected from patients with CCA prior to and during chemotherapy and were subjected to deep sequencing of 15 genes frequently mutated in CCA. A set of ctDNA samples was also submitted for 710 gene oncopanel sequencing to identify progression signatures. The blood/tissue concordance was 74% overall and 92% for intrahepatic tumors only. Variant allele frequency (VAF) in ctDNA correlated with tumor load and in the group of intrahepatic CCA with PFS. 63% of therapy naive patients had their mutational profile changed during chemotherapy. A set of 76 potential progression driver genes was identified among 710 candidates. The molecular landscape of CCA is accessible via ctDNA. This could be helpful to facilitate diagnosis and personalize and adapt therapeutic strategies.

Abstract A45: HPV sequencing facilitates ultrasensitive detection of HPV circulating tumor DNA

2020 ◽  
Author(s):  
Eric Leung ◽  
Kathy Han ◽  
Jinfeng Zou ◽  
Zhen Zhao ◽  
Yangqiao Zheng ◽  
...  
Keyword(s):  
Circulating Tumor Dna ◽  
Ultrasensitive Detection ◽  
Tumor Dna

Analysis of circulating tumor DNA by targeted ultra-deep sequencing across various non-Hodgkin lymphoma subtypes

2019 ◽  
Vol 60 (9) ◽  
pp. 2237-2246 ◽  
Author(s):  
Seung-Ho Shin ◽  
Yeon Jeong Kim ◽  
Danbi Lee ◽  
Duck Cho ◽  
Young Hyeh Ko ◽  
...  
Keyword(s):  
Hodgkin Lymphoma ◽  
Deep Sequencing ◽  
Circulating Tumor Dna ◽  
Non Hodgkin Lymphoma ◽  
Tumor Dna

Noninvasive and Ultrasensitive Quantitation of Circulating Tumor DNA by Hybrid Capture and Deep Sequencing

2013 ◽  
Vol 87 (2) ◽  
pp. S92
Author(s):  
S.V. Bratman ◽  
A.M. Newman ◽  
J. To ◽  
J.F. Wynne ◽  
J.W. Neal ◽  
...  
Keyword(s):  
Deep Sequencing ◽  
Circulating Tumor Dna ◽  
Hybrid Capture ◽  
Tumor Dna
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