DNA Topoisomerases in DNA Repair and DNA Damage Tolerance

1998 ◽  
pp. 517-537 ◽  
Author(s):  
John L. Nitiss
Keyword(s):  
Dna Damage ◽  
Dna Repair ◽  
Damage Tolerance ◽  
Dna Damage Tolerance ◽  
Dna Topoisomerases

scholarly journals Maturation of telomere 3’-overhangs is linked to the replication stress response

2020 ◽  
Author(s):  
Erin E. Henninger ◽  
Pascale Jolivet ◽  
Emilie Fallet ◽  
Mohcen Benmounah ◽  
Zhou Xu ◽  
...  
Keyword(s):  
Dna Damage ◽  
Dna Repair ◽  
Stress Response ◽  
Ubiquitin Ligase ◽  
Replication Fork ◽  
Damage Tolerance ◽  
Dna Helicase ◽  
Dna Damage Tolerance ◽  
Telomeric Repeats ◽  
Telomere Replication

AbstractPassage of the replication fork through telomeric repeats necessitates additional DNA processing by DNA repair factors, to regenerate the terminal 3’-overhang structure at leading telomeres. These factors are prevented from promoting telomeric recombination or fusion by an uncharacterized mechanism. Here we show that Rad5, a DNA helicase and ubiquitin ligase involved in the DNA damage tolerance pathway, participates in this mechanism. Rad5 is enriched at telomeres during telomere replication. Accelerated senescence seen in the absence of telomerase and Rad5, can be compensated for by a pathway involving the Rad51 recombinase and counteracted by the helicase Srs2. However, this pathway is only active at short telomeres. Instead, the ubiquitous activity of Rad5 during telomere replication is necessary for the proper reconstitution of the telomeric 3’-overhang, indicating that Rad5 is required to coordinate telomere maturation during telomere replication.

scholarly journals The DNA repair transcriptome in severe COPD

2018 ◽  
Vol 52 (4) ◽  
pp. 1701994 ◽  
Author(s):  
Maor Sauler ◽  
Maxime Lamontagne ◽  
Eric Finnemore ◽  
Jose D. Herazo-Maya ◽  
John Tedrow ◽  
...  
Keyword(s):  
Dna Damage ◽  
Dna Repair ◽  
Damage Tolerance ◽  
Excision Repair ◽  
Gene Set Enrichment Analysis ◽  
Differentially Expressed ◽  
Chronic Obstructive ◽  
Dna Damage Tolerance ◽  
Systematic Analysis ◽  
Severe Copd

Inadequate DNA repair is implicated in the pathogenesis of chronic obstructive pulmonary disease (COPD). However, the mechanisms that underlie inadequate DNA repair in COPD are poorly understood. We applied an integrative genomic approach to identify DNA repair genes and pathways associated with COPD severity.We measured the transcriptomic changes of 419 genes involved in DNA repair and DNA damage tolerance that occur with severe COPD in three independent cohorts (n=1129). Differentially expressed genes were confirmed with RNA sequencing and used for patient clustering. Clinical and genome-wide transcriptomic differences were assessed following cluster identification. We complemented this analysis by performing gene set enrichment analysis, Z-score and weighted gene correlation network analysis to identify transcriptomic patterns of DNA repair pathways associated with clinical measurements of COPD severity.We found 15 genes involved in DNA repair and DNA damage tolerance to be differentially expressed in severe COPD. K-means clustering of COPD cases based on this 15-gene signature identified three patient clusters with significant differences in clinical characteristics and global transcriptomic profiles. Increasing COPD severity was associated with downregulation of the nucleotide excision repair pathway.Systematic analysis of the lung tissue transcriptome of individuals with severe COPD identified DNA repair responses associated with disease severity that may underlie COPD pathogenesis.

scholarly journals Homologous recombination in DNA repair and DNA damage tolerance

Cell Research ◽  
2008 ◽  
Vol 18 (1) ◽  
pp. 99-113 ◽  
Author(s):  
Xuan Li ◽  
Wolf-Dietrich Heyer
Keyword(s):  
Dna Damage ◽  
Dna Repair ◽  
Homologous Recombination ◽  
Damage Tolerance ◽  
Dna Damage Tolerance

scholarly journals Novel conserved motifs in Rev1 C-terminus are required for mutagenic DNA damage tolerance

DNA Repair ◽  
2008 ◽  
Vol 7 (9) ◽  
pp. 1455-1470 ◽  
Author(s):  
Sanjay D'Souza ◽  
Lauren S. Waters ◽  
Graham C. Walker
Keyword(s):  
Dna Damage ◽  
Damage Tolerance ◽  
Dna Damage Tolerance ◽  
Conserved Motifs ◽  
C Terminus

scholarly journals DNA-damage tolerance mediated by PCNA•Ub fusions in human cells is dependent on Rev1 but not Polη

2013 ◽  
Vol 41 (15) ◽  
pp. 7356-7369 ◽  
Author(s):  
Zhoushuai Qin ◽  
Mengxue Lu ◽  
Xin Xu ◽  
Michelle Hanna ◽  
Naoko Shiomi ◽  
...  
Keyword(s):  
Dna Damage ◽  
Damage Tolerance ◽  
Human Cells ◽  
Dna Damage Tolerance

Deubiquitinating PCNA: a downside to DNA damage tolerance

2006 ◽  
Vol 8 (4) ◽  
pp. 303-305 ◽  
Author(s):  
Helle D. Ulrich
Keyword(s):  
Dna Damage ◽  
Damage Tolerance ◽  
Dna Damage Tolerance

DNA-Damage Tolerance

2008 ◽  
pp. 888-890
Author(s):  
Xianghong Wang
Keyword(s):  
Dna Damage ◽  
Damage Tolerance ◽  
Dna Damage Tolerance
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