An Intracerebral Tumor Necrosis Factor-α Infusion Model for Inflammation in Alzheimer’s Disease

2000 ◽  
pp. 93-112
Author(s):  
Kimberly B. Bjugstad ◽  
Gary W. Arendash
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Intracerebral Tumor ◽  
Factor Α ◽  
Necrosis Factor

scholarly journals Microglial derived tumor necrosis factor-α drives Alzheimer's disease-related neuronal cell cycle events

2014 ◽  
Vol 62 ◽  
pp. 273-285 ◽  
Author(s):  
Kiran Bhaskar ◽  
Nicole Maphis ◽  
Guixiang Xu ◽  
Nicholas H. Varvel ◽  
Olga N. Kokiko-Cochran ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Cell Cycle ◽  
Alzheimer's Disease ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Neuronal Cell ◽  
Factor Α ◽  
Necrosis Factor

scholarly journals Tumor necrosis factor α Inhibition for Alzheimer’s Disease

2017 ◽  
Vol 9 ◽  
pp. 117957351770927 ◽  
Author(s):  
Rudy Chang ◽  
Kei-Lwun Yee ◽  
Rachita K Sumbria
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Short Review ◽  
Tnf Α ◽  
Factor Α ◽  
Ad Therapy ◽  
Necrosis Factor

Tumor necrosis factor α (TNF-α) plays a central role in the pathophysiology of Alzheimer’s disease (AD). Food and Drug Administration–approved biologic TNF-α inhibitors are thus a potential treatment for AD, but they do not cross the blood-brain barrier. In this short review, we discuss the involvement of TNF-α in AD, challenges associated with the development of existing biologic TNF-α inhibitors for AD, and potential therapeutic strategies for targeting TNF-α for AD therapy.

T-cell tumor necrosis factor-α binding in Alzheimer's disease: Effect of donepezil

1998 ◽  
Vol 8 ◽  
pp. S276
Author(s):  
P. Bongioanni ◽  
B. Boccardi ◽  
D. Pellegrino ◽  
C. Baldini ◽  
L. Gabrielli ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
T Cell ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Cell Tumor ◽  
Disease Effect ◽  
Factor Α ◽  
Necrosis Factor

Tumor necrosis factor α polymorphism C-850T is not associated with Alzheimer's disease and vascular dementia in an Italian population

2003 ◽  
Vol 344 (2) ◽  
pp. 135-137 ◽  
Author(s):  
Liana Terreni ◽  
Sergio Fogliarino ◽  
Pierluigi Quadri ◽  
Rosa Maria Ruggieri ◽  
Federico Piccoli ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Tumor Necrosis Factor ◽  
Vascular Dementia ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Italian Population ◽  
Factor Α ◽  
Necrosis Factor

scholarly journals Inhibiting tumor necrosis factor-α before amyloidosis prevents synaptic deficits in an Alzheimer's disease model

2016 ◽  
Vol 47 ◽  
pp. 41-49 ◽  
Author(s):  
Chelsea Cavanagh ◽  
Yiu Chung Tse ◽  
Huy-Binh Nguyen ◽  
Slavica Krantic ◽  
John C.S. Breitner ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Disease Model ◽  
Factor Α ◽  
Necrosis Factor

Tumor necrosis factor-α−308A/G polymorphism is associated with age at onset of Alzheimer's disease

2006 ◽  
Vol 127 (6) ◽  
pp. 567-571 ◽  
Author(s):  
Domenico Lio ◽  
Giorgio Annoni ◽  
Federico Licastro ◽  
Antonino Crivello ◽  
Giusi Irma Forte ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Age At Onset ◽  
Factor Α ◽  
Necrosis Factor
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