Antiviral Chemotherapy for Viral Hepatitis

Hepatic purine and pyrimidine metabolism: implications for antiviral chemotherapy of viral hepatitis

Liver International ◽

10.1111/j.1600-0676.1995.tb00667.x ◽

2008 ◽

Vol 15 (4) ◽

pp. 169-184 ◽

Cited By ~ 40

Author(s):

Timothy Shaw ◽

Stephen A. Locarnini

Keyword(s):

Viral Hepatitis ◽

Pyrimidine Metabolism ◽

Antiviral Chemotherapy

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Viral hepatitis: an occupational hazard of medical personnel. Experience of the Yalenew Haven Hospital, 1952 to 1965

JAMA ◽

10.1001/jama.195.5.362 ◽

1966 ◽

Vol 195 (5) ◽

pp. 362-364 ◽

Cited By ~ 11

Author(s):

E. B. Byrne

Keyword(s):

Viral Hepatitis ◽

Medical Personnel ◽

Occupational Hazard ◽

Haven Hospital

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Qualitative study on “hydropic degeneration” of The hepatocytes in viral hepatitis

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s042482010016039x ◽

1990 ◽

Vol 48 (3) ◽

pp. 568-569

Author(s):

Le Meizhao ◽

Ye Ming ◽

Song Xiaoming ◽

Xu Jiazhang

Keyword(s):

Qualitative Study ◽

Viral Hepatitis ◽

Chronic Active Hepatitis ◽

Microscopic Observation ◽

Hydropic Degeneration ◽

Light Microscopic Observation ◽

Biopsy Specimens ◽

Endoplasm Reticulum ◽

Mixed Fluid ◽

Peripheral Cytoplasm

“Hydropic degeneration” of the hepatocytes are often found in biopsy of the liver of some kinds of viral hepatitis. Light microscopic observation, compareted with the normal hepatocytes, they are enlarged, sometimes to a marked degree when the term “balloning” degeneration is used. Their cytoplasm rarefied, and show some clearness in the peripheral cytoplasm, so, it causes a hydropic appearance, the cytoplasm around the nuclei is granulated. Up to the present, many studies belive that main ultrastructural chenges of hydropic degeneration of the hepatocytes are results of the RER cristae dilatation with degranulation and disappearance of glycogen granules.The specimens of this study are fixed with the mixed fluid of the osmium acidpotassium of ferricyanide, Epon-812 embed. We have observed 21 cases of biopsy specimens with chronic severe hepatitis and severe chronic active hepatitis, and found that the clear fields in the cytoplasm actually are a accumulating place of massive glycogen. The granules around the nuclei are converging mitochondria, endoplasm reticulum and other organelles.

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