Lingual Mucosa and Posterior Auricular Skin Grafts

2008 ◽  
pp. 137-139
Author(s):  
Steven B. Brandes
Keyword(s):  
Skin Grafts ◽  
Lingual Mucosa

scholarly journals IMPLANTATION, TRANSPLANTATION, AND EPITHELIAL-MESENCHYMAL RELATIONSHIPS IN THE RAT UTERUS

1970 ◽  
Vol 132 (4) ◽  
pp. 721-736 ◽  
Author(s):  
Alan E. Beer ◽  
R. E. Billingham
Keyword(s):  
In Utero ◽  
Epidermal Cells ◽  
Uterine Horn ◽  
Skin Grafts ◽  
Modus Operandi ◽  
Rat Uterus ◽  
Lingual Mucosa ◽  
Endometrial Epithelium ◽  
Monodisperse Suspensions ◽  
Skin Epidermis

Free tail skin grafts or suspensions of viable epidermal cells have been placed in the atraumatized uterus of isologous rat hosts and allowed to "implant" of their own accord to study the possible uniqueness of this site for other than nature's transplants, i.e. conceptuses, and its response to unnatural grafts. Despite the presence of an intact endometrial epithelium, free skin grafts heal-in rapidly, provided that a state of estrogen excess is established at the time of transplantation. In the absence of estrogen most of the grafts failed to implant. Once established, the grafts survive indefinitely without further estrogen. However, if at any stage a state of continual estrus is established, skin epidermis migrates centrifugally from the graft perimeter invasively replacing the native uterine epithelium. The results of an analysis of the modus operandi of this estrogen-facilitated epidermal migration in utero sustain the view that the hormone acts upon the uterine stroma rather than upon the epidermal cells. When grafts of lingual mucosa or vaginal "skin" were placed in the uteri of rats maintained in chronic estrus, migration of epidermis took place even more vigorously than from tail skin. These epithelia conserved their distinctive histologic specificities indefinitely when growing as heterotypic recombinants on the alien mesenchymal stroma of the uterus. Monodisperse suspensions of epidermal cells appear to "implant" and establish small epidermal plaques in the uterus only at sites predestined to accept conceptuses. That the endocrinologic parameters for the establishment of skin grafts in the uterus are similar to those for blastocysts is suggested by the finding that both kinds of graft can become established in the same uterine horn in the absence of exogenous hormones.

Utilizing Full-Thickness Skin Grafts for Vaginal Reconstruction

1988 ◽  
Vol 15 (3) ◽  
pp. 443-448 ◽  
Author(s):  
Richard C. Sadove ◽  
Charles E. Horton
Keyword(s):  
Skin Grafts ◽  
Full Thickness ◽  
Vaginal Reconstruction ◽  
Full Thickness Skin ◽  
Thickness Skin

Harvesting Split-thickness Skin Grafts with Lateral Femoral Cutaneous Nerve Block

2004 ◽  
Vol 66 (6) ◽  
pp. 612-614
Author(s):  
Yukiko TERAMOTO ◽  
Makoto ICHIMIYA ◽  
Yuko TAKITA ◽  
Yoshiaki YOSHIKAWA ◽  
Masahiko MUTO
Keyword(s):  
Nerve Block ◽  
Cutaneous Nerve ◽  
Lateral Femoral Cutaneous Nerve ◽  
Skin Grafts ◽  
Thickness Skin ◽  
Femoral Cutaneous Nerve

scholarly journals THE GENETIC DIVERGENCE OF SUBLINES AS ASSESSED BY HISTOCOMPATIBILITY TESTING

Genetics ◽  
1973 ◽  
Vol 75 (4) ◽  
pp. 671-677
Author(s):  
Willys K Silvers ◽  
David L Gasser
Keyword(s):  
Genetic Divergence ◽  
Inbred Strains ◽  
Skin Grafts ◽  
Inbred Strains Of Mice ◽  
Inbred Rats

ABSTRACT The degree of genetic divergence which has occurred between a number of inbred strains of mice and between two sublines of inbred rats was assessed by determining the fate of inter-subline skin grafts. Sublines which had been separated for 29 and 42 generations possessed no detectable incompatibility, while three combinations of sublines judged to have been maintained apart for from 123 to 129 generations showed slight degrees of histoincompatibility. One pair of sublines which had been separated for 119 generations demonstrated a marked degree of incompatibility, and an F2 test suggested that mutations had occurred at four or five histocompatibility loci.

Skin Grafts

1994 ◽  
Vol 27 (1) ◽  
pp. 25-37 ◽  
Author(s):  
Guy J. Petruzzelli ◽  
Jonas T. Johnson
Keyword(s):  
Skin Grafts

scholarly journals Reducing alcohol and/or cocaine-induced reward and toxicity via an epidermal stem cell-based gene delivery platform

2021 ◽  
Author(s):  
Qingyao Kong ◽  
Yuanyuan Li ◽  
Jiping Yue ◽  
Xiaoyang Wu ◽  
Ming Xu
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Gene Delivery ◽  
Unmet Need ◽  
Skin Grafts ◽  
Epidermal Stem Cell ◽  
Epidermal Stem Cells ◽  
Concurrent Use ◽  
Delivery Platform ◽  
Glucagon Like Peptide 1

AbstractAlcohol use disorder (AUD) is one of the foremost public health problems. Alcohol is also frequently co-abused with cocaine. There is a huge unmet need for the treatment of AUD and/or cocaine co-abuse. We recently demonstrated that skin grafts generated from mouse epidermal stem cells that had been engineered by CRISPR-mediated genome editing could be transplanted onto mice as a gene delivery platform. Here, we show that expression of the glucagon-like peptide-1 (GLP1) gene delivered by epidermal stem cells attenuated development and reinstatement of alcohol-induced drug-taking and seeking as well as voluntary oral alcohol consumption. GLP1 derived from the skin grafts decreased alcohol-induced increase in dopamine levels in the nucleus accumbens. In exploring the potential of this platform in reducing concurrent use of drugs, we developed a novel co-grafting procedure for both modified human butyrylcholinesterase (hBChE)- and GLP1-expressing cells. Epidermal stem cell-derived hBChE and GLP1 reduced acquisition of drug-taking and toxicity induced by alcohol and cocaine co-administration. These results imply that cutaneous gene delivery through skin transplants may add a new option to treat drug abuse and co-abuse.

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