The Role of Mitochondrial Reactive Oxygen Species Formation for Age-Induced Vascular Dysfunction

2010 ◽  
pp. 237-257 ◽  
Author(s):  
Andreas Daiber ◽  
Joachim Kienhoefer ◽  
Rebecca Zee ◽  
Philip Wenzel ◽  
Volker Ullrich ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Vascular Dysfunction ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Mitochondrial Reactive Oxygen Species ◽  
Reactive Oxygen Species Formation ◽  
Species Formation

scholarly journals Role of Focal Adhesion Tyrosine Kinases in GPVI-Dependent Platelet Activation and Reactive Oxygen Species Formation

PLoS ONE ◽  
2014 ◽  
Vol 9 (11) ◽  
pp. e113679 ◽  
Author(s):  
Naadiya Carrim ◽  
Tony G. Walsh ◽  
Alessandra Consonni ◽  
Mauro Torti ◽  
Michael C. Berndt ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Platelet Activation ◽  
Focal Adhesion ◽  
Tyrosine Kinases ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Reactive Oxygen Species Formation ◽  
Species Formation

scholarly journals Carbon Monoxide Activates Autophagy via Mitochondrial Reactive Oxygen Species Formation

2011 ◽  
Vol 45 (4) ◽  
pp. 867-873 ◽  
Author(s):  
Seon-Jin Lee ◽  
Stefan W. Ryter ◽  
Jin-Fu Xu ◽  
Kiichi Nakahira ◽  
Hong Pyo Kim ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Carbon Monoxide ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Mitochondrial Reactive Oxygen Species ◽  
Reactive Oxygen Species Formation ◽  
Species Formation

scholarly journals Cytotoxic and Antitumor Activity of Sulforaphane: The Role of Reactive Oxygen Species

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Piero Sestili ◽  
Carmela Fimognari
Keyword(s):  
Reactive Oxygen Species ◽  
Reactive Oxygen ◽  
Target Cells ◽  
Cancer Therapies ◽  
Oxygen Species ◽  
Reactive Oxygen Species Formation ◽  
Species Formation

According to recent estimates, cancer continues to remain the second leading cause of death and is becoming the leading one in old age. Failure and high systemic toxicity of conventional cancer therapies have accelerated the identification and development of innovative preventive as well as therapeutic strategies to contrast cancer-associated morbidity and mortality. In recent years, increasing body ofin vitroandin vivostudies has underscored the cancer preventive and therapeutic efficacy of the isothiocyanate sulforaphane. In this review article, we highlight that sulforaphane cytotoxicity derives from complex, concurring, and multiple mechanisms, among which the generation of reactive oxygen species has been identified as playing a central role in promoting apoptosis and autophagy of target cells. We also discuss the site and the mechanism of reactive oxygen species’ formation by sulforaphane, the toxicological relevance of sulforaphane-formed reactive oxygen species, and the death pathways triggered by sulforaphane-derived reactive oxygen species.

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