Studying Vascular Progenitor Cells in a Neonatal Mouse Model

2012 ◽  
pp. 235-242
Author(s):  
Kirsten A. Kienstra ◽  
Karen K. Hirschi
Keyword(s):  
Mouse Model ◽  
Progenitor Cells ◽  
Neonatal Mouse ◽  
Vascular Progenitor Cells

The effect of vascular progenitor cells on chronic cerebral hypoperfusion mouse model

2009 ◽  
Vol 65 ◽  
pp. S123
Author(s):  
Kazuo Washida ◽  
Masafumi Ihara ◽  
Jun Takahashi ◽  
Hidefumi Ito ◽  
Hidekazu Tomimoto ◽  
...  
Keyword(s):  
Mouse Model ◽  
Progenitor Cells ◽  
Chronic Cerebral Hypoperfusion ◽  
Cerebral Hypoperfusion ◽  
Vascular Progenitor Cells

Neonatal Mouse Model: Review of Methods and Results

2001 ◽  
Vol 29 (5) ◽  
pp. 128-137 ◽  
Author(s):  
R. Michael McClain ◽  
Douglas Keller ◽  
Dan Casciano ◽  
Peter Fu ◽  
James MacDonald ◽  
...  
Keyword(s):  
Mouse Model ◽  
Neonatal Mouse ◽  
Model Review

scholarly journals Protective effect of enterovirus-71 (EV71) virus-like particle vaccine against lethal EV71 infection in a neonatal mouse model

2015 ◽  
Vol 12 (2) ◽  
pp. 2473-2480 ◽  
Author(s):  
LEI CAO ◽  
FENGFENG MAO ◽  
ZHENG PANG ◽  
YAO YI ◽  
FENG QIU ◽  
...  
Keyword(s):  
Mouse Model ◽  
Protective Effect ◽  
Enterovirus 71 ◽  
Neonatal Mouse ◽  
Ev71 Infection ◽  
Virus Like Particle

scholarly journals Regulatory Mechanism for Exfoliative Toxin Production inStaphylococcus aureus

2011 ◽  
Vol 79 (4) ◽  
pp. 1660-1670 ◽  
Author(s):  
Fuminori Kato ◽  
Noriko Kadomoto ◽  
Yuko Iwamoto ◽  
Katsuaki Bunai ◽  
Hitoshi Komatsuzawa ◽  
...  
Keyword(s):  
Mouse Model ◽  
Regulatory Mechanism ◽  
Toxin Production ◽  
Neonatal Mouse ◽  
Epidermal Keratinocytes ◽  
Global Regulators ◽  
Exfoliative Toxin ◽  
Blistering Disease

ABSTRACTThe exfoliative toxin (ET) is a major virulence factor ofStaphylococcus aureusthat causes bullous impetigo and its disseminated form, staphylococcal scalded-skin syndrome (SSSS). ET selectively digests one of the intracellular adhesion molecules, desmoglein 1, of epidermal keratinocytes and causes blisters due to intraepidermal cell-cell dissociation. MostS. aureusstrains that cause blistering disease produce either ETA or ETB. They are serologically distinct molecules, where ETA is encoded on a phage genome and ETB is enocded on a large plasmid. ETA-producingS. aureusstrains are frequently isolated from impetigo patients, and ETB-producingS. aureusstrains are isolated from SSSS. ET-induced blister formation can be reproduced with the neonatal mouse. To determine the regulatory mechanism of ET production, we investigated the role of the two-component systems and global regulators foretaoretbexpressionin vitroandin vivowith the mouse model. Western blot and transcription analyses using a series of mutants demonstrate ETA production was downregulated bysigB,sarS, andsarA, while ETB production was downregulated bysigBandsarAbut not bysarS. Production of both toxins is upregulated bysaeRS,arlRS, andagrCA. Furthermore, by thein vivoneonatal mouse model,sigBandsarSbut notsarAnegatively regulate the exfoliation activity of the ETA-producing strain, whilesarAnegatively regulates the ETB-producing strain. In both strains,saeRS,arlRS, andagrCApositively regulate the exfoliation activityin vivo. The data illustrate similar but distinct regulatory mechanisms for ETA and ETB productionin S. aureus in vitroas well asin vivo.

scholarly journals Crawling with Virus: Translational Insights from a Neonatal Mouse Model on the Pathogenesis of Respiratory Syncytial Virus in Infants

2015 ◽  
Vol 90 (1) ◽  
pp. 2-4 ◽  
Author(s):  
Dahui You ◽  
Jordy Saravia ◽  
David Siefker ◽  
Bishwas Shrestha ◽  
Stephania A. Cormier
Keyword(s):  
Immune Response ◽  
Respiratory Syncytial Virus ◽  
Mouse Model ◽  
Severe Infection ◽  
Neonatal Mouse ◽  
Cell Type ◽  
Human Infants ◽  
Rsv Infection ◽  
Syncytial Virus ◽  
Infant Immune Response

The infant immune response to respiratory syncytial virus (RSV) remains incompletely understood. Here we review the use of a neonatal mouse model of RSV infection to mimic severe infection in human infants. We describe numerous age-specific responses, organized by cell type, observed in RSV-infected neonatal mice and draw comparisons (when possible) to human infants.

scholarly journals A neonatal mouse model of central nervous system infections caused by Coxsackievirus B5

2018 ◽  
Vol 7 (1) ◽  
pp. 1-11 ◽  
Author(s):  
Qunying Mao ◽  
Xiaotian Hao ◽  
Yalin Hu ◽  
Ruixiao Du ◽  
Shuhui Lang ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Mouse Model ◽  
Neonatal Mouse ◽  
Central Nervous System Infections

Resident vascular progenitor cells

2011 ◽  
Vol 50 (2) ◽  
pp. 304-311 ◽  
Author(s):  
Evelyn Torsney ◽  
Qingbo Xu
Keyword(s):  
Progenitor Cells ◽  
Vascular Progenitor Cells
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