Stem Cells in Ligament Tissue Engineering

2013 ◽  
pp. 549-562
Author(s):  
Mukai Chimutengwende-Gordon ◽  
Wasim S. Khan
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Ligament Tissue Engineering

Fiber/collagen composites for ligament tissue engineering: influence of elastic moduli of sparse aligned fibers on mesenchymal stem cells

2016 ◽  
Vol 104 (8) ◽  
pp. 1894-1901 ◽  
Author(s):  
Patrick S. Thayer ◽  
Scott S. Verbridge ◽  
Linda A. Dahlgren ◽  
Sanjeev Kakar ◽  
Scott A. Guelcher ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Elastic Moduli ◽  
Aligned Fibers ◽  
Ligament Tissue Engineering

scholarly journals Ligament Tissue Engineering Using a Novel Porous Polycaprolactone Fumarate Scaffold and Adipose Tissue-Derived Mesenchymal Stem Cells Grown in Platelet Lysate

2015 ◽  
Vol 21 (21-22) ◽  
pp. 2703-2713 ◽  
Author(s):  
Eric R. Wagner ◽  
Dalibel Bravo ◽  
Mahrokh Dadsetan ◽  
Scott M. Riester ◽  
Steven Chase ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Adipose Tissue ◽  
Platelet Lysate ◽  
Ligament Tissue Engineering

In vitro Three Dimensional Scaffold-free Construct of Human Adipose-derived Stem Cells in Coculture with Endothelial Cells and Fibroblasts

2017 ◽  
Vol 68 (6) ◽  
pp. 1341-1344
Author(s):  
Grigore Berea ◽  
Gheorghe Gh. Balan ◽  
Vasile Sandru ◽  
Paul Dan Sirbu
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Endothelial Cells ◽  
Single Cell ◽  
Cell Line ◽  
Bone Repair ◽  
Umbilical Vein ◽  
Human Fibroblasts ◽  
Three Dimensional ◽  
Adipose Derived Stem Cells

Complex interactions between stem cells, vascular cells and fibroblasts represent the substrate of building microenvironment-embedded 3D structures that can be grafted or added to bone substitute scaffolds in tissue engineering or clinical bone repair. Human Adipose-derived Stem Cells (hASCs), human umbilical vein endothelial cells (HUVECs) and normal dermal human fibroblasts (NDHF) can be mixed together in three dimensional scaffold free constructs and their behaviour will emphasize their potential use as seeding points in bone tissue engineering. Various combinations of the aforementioned cell lines were compared to single cell line culture in terms of size, viability and cell proliferation. At 5 weeks, viability dropped for single cell line spheroids while addition of NDHF to hASC maintained the viability at the same level at 5 weeks Fibroblasts addition to the 3D construct of stem cells and endothelial cells improves viability and reduces proliferation as a marker of cell differentiation toward osteogenic line.

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