scholarly journals Computer-Aided Selection of Participatory Design Methods

2019 ◽  
pp. 466-474
Author(s):  
Michael Bojko ◽  
Ralph Riedel ◽  
Mandy Tawalbeh
Keyword(s):  
Participatory Design ◽  
Design Methods ◽  
Computer Aided ◽  
Selection Of

Prospects for Discovering the Secondary Metabolites of Cordyceps Sensu Lato by the Integrated Strategy

2020 ◽  
Vol 17 (2) ◽  
pp. 97-120
Author(s):  
Shabana Bibi ◽  
Yuan-Bing Wang ◽  
De-Xiang Tang ◽  
Mohammad Amjad Kamal ◽  
Hong Yu
Keyword(s):  
Drug Design ◽  
Biological Activities ◽  
Design Methods ◽  
Chinese Herbs ◽  
Active Metabolites ◽  
Computer Aided Drug Design ◽  
Design Concepts ◽  
Conventional Drug ◽  
Computer Aided ◽  
Design Techniques

: Some species of Cordyceps sensu lato are famous Chinese herbs with significant biological activities, often used as edible food and traditional medicine in China. Cordyceps represents the largest entomopathogenic group of fungi, including 40 genera and 1339 species in three families and incertae sedis of Hypocreales. Objective: Most of the Cordyceps-derivatives have been approved clinically for the treatment of various diseases such as diabetes, cancers, inflammation, cardiovascular, renal and neurological disorders and are used worldwide as supplements and herbal drugs, but there is still need for highly efficient Cordyceps-derived drugs for fatal diseases with approval of the U.S. Food and Drug Administration. Methods: Computer-aided drug design concepts could improve the discovery of putative Cordyceps- derived medicine within less time and low budget. The integration of computer-aided drug design methods with experimental validation has contributed to the successful discovery of novel drugs. Results: This review focused on modern taxonomy, active metabolites, and modern drug design techniques that could accelerate conventional drug design and discovery of Cordyceps s. l. Successful application of computer-aided drug design methods in Cordyceps research has been discussed. Conclusion: It has been concluded that computer-aided drug design techniques could influence the multiple target-focused drug design, because each metabolite of Cordyceps has shown significant activities for the various diseases with very few or no side effects.

Zoning in on Tankyrases: A Brief Review on the Past, Present and Prospective Studies

2020 ◽  
Vol 19 (16) ◽  
pp. 1920-1934
Author(s):  
Xylia Q. Peters ◽  
Thembeka H. Malinga ◽  
Clement Agoni ◽  
Fisayo A. Olotu ◽  
Mahmoud E.S. Soliman
Keyword(s):  
Drug Design ◽  
Small Molecule ◽  
Small Molecule Inhibitors ◽  
Design Methods ◽  
Selective Inhibitors ◽  
Computer Aided Drug Design ◽  
Cellular Processes ◽  
Conventional Drug ◽  
Computer Aided ◽  
Tankyrase 1

Background: Tankyrases are known for their multifunctionalities within the poly(ADPribose) polymerases family and playing vital roles in various cellular processes which include the regulation of tumour suppressors. Tankyrases, which exist in two isoforms; Tankyrase 1 and 2, are highly homologous and an integral part of the Wnt β -catenin pathway that becomes overly dysregulated when hijacked by pro-carcinogenic machineries. Methods: In this review, we cover the distinct roles of the Tankyrase isoforms and their involvement in the disease pathogenesis. Also, we provide updates on experimentally and computationally derived antagonists of Tankyrase whilst highlighting the precedence of integrative computer-aided drug design methods towards the discovery of selective inhibitors. Results: Despite the high prospects embedded in the therapeutic targeting and blockade of Tankyrase isoforms, the inability of small molecule inhibitors to achieve selective targeting has remained a major setback, even until date. This explains numerous incessant drug design efforts geared towards the development of highly selective inhibitors of the respective Tankyrase isoforms since they mediate distinct aberrancies in disease progression. Therefore, considering the setbacks of conventional drug design methods, can computer-aided approaches actually save the day? Conclusion: The implementation of computer-aided drug design techniques in Tankyrase research could help complement experimental methods and facilitate ligand/structure-based design and discovery of small molecule inhibitors with enhanced selectivity.

Computer-aided selection of a polymer matrix for polyaniline conductive blends

1998 ◽  
Vol 9 (9) ◽  
pp. 563-568 ◽  
Author(s):  
D. Alperstein ◽  
M. Narkis ◽  
M. Zilberman ◽  
A. Siegmann
Keyword(s):  
Polymer Matrix ◽  
Computer Aided ◽  
Selection Of

scholarly journals Applicability of 3D-factory simulation software for computer-aided participatory design for industrial workplaces and processes

Procedia CIRP ◽  
2021 ◽  
Vol 99 ◽  
pp. 122-126
Author(s):  
Luigi Pelliccia ◽  
Michael Bojko ◽  
Riccardo Prielipp ◽  
Ralph Riedel
Keyword(s):  
Participatory Design ◽  
Simulation Software ◽  
Computer Aided

Enhancing CAD For The Forensic Engineer

1984 ◽  
Vol 2 (1) ◽  
Author(s):  
Lindley Manning
Keyword(s):  
Computer Graphics ◽  
Photographic Evidence ◽  
Computer Aided ◽  
Engineering Drawings ◽  
Forensic Engineering ◽  
Selection Of

The purpose of this paper is to inform the Academy of an application of computer graphics that has been successful in the court room and which has the potential for extension to many related needs of the forensic engineer. An additional purpose is to examine the possibility of cooperation within the Academy to make a broad database and selection of equipment available to the members. Attentive engineers of today are well aware of the growing use and impact of computer-aided drafting, design and analysis in a wide variety of industries. In our field, we are aware of large analysis programs which have been used with success in court, for example the CRASH series. The authors forensic engineering partnership has developed ways to utilize the more widely available drafting systems to inexpensively fill the gap between photographic evidence and full engineering drawings. We have also found that CAD drawings appear to have more impact in court than hand done drawings. In some cases

Translation Technology

2015 ◽  
Author(s):  
Lynne Bowker ◽  
Gloria Corpas Pastor
Keyword(s):  
Professional Competence ◽  
High Quality ◽  
Translation Tools ◽  
Use Of Technology ◽  
Computer Aided ◽  
Increase Productivity ◽  
Selection Of

In today’s market, the use of technology by translators is no longer a luxury but a necessity if they are to meet rising market demands for the quick delivery of high-quality texts in many languages. This chapter describes a selection of computer-aided translation tools, resources, and applications, most commonly employed by translators to help them increase productivity while maintaining high quality in their work. This chapter also considers some of the ways in which translation technology has influenced the practice and the product of translation, as well as translators’ professional competence and their preferences with regard to tools and resources.

Improvisation as Technique and Practice for Design

2020 ◽  
pp. 170-187
Author(s):  
Kristian Kloeckl
Keyword(s):  
Performing Arts ◽  
Participatory Design ◽  
Role Play ◽  
Design Methods ◽  
Design Approach ◽  
Concrete Situation

This chapter explores the richness of practice-based frameworks and improvisation techniques in the performing arts. It illustrates how these can become a resource for an improvisation-based design approach by developing a concrete hybrid city application. Participatory design methods use improvisation to develop applications in collaboration with users. They attempt to unlock tacit kinds of knowing and gain firsthand appreciation of existing or future conditions by engaging participants and designers together in a concrete situation. In role-play techniques, for example, cards are handed to each participant that introduce the scene and contain information about rules associated with that specific scene, goals to be achieved, and the roles that participants enact.

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