Long Noncoding RNAs in Cardiovascular Diseases

Author(s):  
Laura Schoppe ◽  
Tim Meinecke ◽  
Patrick Hofmann ◽  
Ulrich Laufs ◽  
Jes-Niels Boeckel
2020 ◽  
Vol 318 (5) ◽  
pp. H1308-H1315 ◽  
Author(s):  
Lee Toni ◽  
Frehiwet Hailu ◽  
Carmen C. Sucharov

Noncoding RNAs (ncRNAs) are broadly described as RNA molecules that are not translated into protein. The investigation of dysregulated ncRNAs in human diseases such as cancer, neurological, and cardiovascular diseases has been under way for well over a decade. Micro-RNAs and long noncoding RNAs (lncRNAs) are the best characterized ncRNAs. These ncRNAs can have profound effects on the regulation of gene expression during cardiac development and disease. Importantly, ncRNAs are significant regulators of gene expression in several congenital heart diseases and can positively or negatively impact cardiovascular development. In this review, we focus on literature involving micro-RNAs and lncRNAs in the context of pediatric cardiovascular diseases, preclinical models of heart failure, and cardiac development.


2020 ◽  
Vol 27 (1) ◽  
Author(s):  
Chih-Fan Yeh ◽  
Yu-Chen Eugene Chang ◽  
Cheng-Yuan Lu ◽  
Chin-Feng Hsuan ◽  
Wei-Tien Chang ◽  
...  

2016 ◽  
Vol 12 (6) ◽  
pp. 360-373 ◽  
Author(s):  
Johan M. Lorenzen ◽  
Thomas Thum

2015 ◽  
Vol 116 (4) ◽  
pp. 737-750 ◽  
Author(s):  
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Stefanie Dimmeler

2019 ◽  
Vol 29 (2) ◽  
pp. 113-121 ◽  
Author(s):  
Xue-ying Zhang ◽  
Lian-wen Zheng ◽  
Chun-jin Li ◽  
Ying Xu ◽  
Xu Zhou ◽  
...  

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