Vitamin and Trace Element Needs in Chronic Kidney Disease

2020 ◽  
pp. 607-623
Author(s):  
Alison L. Steiber ◽  
Charles Chazot ◽  
Joel D. Kopple
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Trace Element

scholarly journals Trace Elements and Chronic Kidney Disease: A Cross-Sectional Study from Jamaica

2021 ◽  
pp. 79-90
Author(s):  
Adwalia Fevrier-Paul ◽  
Adedamola Soyibo ◽  
Nimal De Silva ◽  
Sylvia Mitchell ◽  
Donovan McGrowder ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Trace Elements ◽  
Kidney Disease ◽  
Trace Element ◽  
Kidney Function ◽  
Inductively Coupled Plasma ◽  
Trace Element Analysis ◽  
Area Under The Curve ◽  
Element Analysis ◽  
Cross Sectional

Background: Several environmental studies have reported that low-level exposure to nephrotoxic elements increases the risk of chronic kidney disease (CKD). In developing countries, finite resources can limit epidemiological studies and environmental risk assessment; however, the unique soil profile in Jamaica has raised some concerns for the potential exposure to populations who are of high risk. Method: This study investigated the potential for using trace element profiling in CKD, by analysing blood concentration levels of vanadium, chromium, iron, cobalt, copper, zinc, selenium, strontium (Sr), arsenic, barium, cadmium, mercury, and lead. Trace element analysis was conducted using inductively coupled plasma mass spectrometry. Results: One hundred and fifty-eight individuals were included and were predominantly of African descent (98%) and their ages ranged from 21 to 90 years old. Three main correlation clusters were evident: firstly, vanadium, chromium, copper, silicon, and selenium, with mercury and barium more distantly related; secondly, lead, arsenic, nickel, and Sr; and thirdly, iron and zinc. Cadmium was an outlier. Blood Sr was strongly associated with estimated glomerular filtration rate (r = -0.83; p<0.001) and strong linear progression models (r2=0.96; p<0.001). Algorithmic models placed Sr as the highest-ranking trace element biomarker (area under the curve: 95.6%; p<0.001). Discussion: The decline in kidney function may result in the retention of non-essential trace elements. Strong corresponding trends between kidney function and blood Sr concentration indicate biomarker potential for a trace element with a unique profile in patients with CKD. Other significant relationships may also be unveiled as CKD biomarkers as trace element profiling is explored in the region.

Vitamin and Trace Element Needs in Chronic Kidney Disease

2013 ◽  
pp. 389-404
Author(s):  
Alison L. Steiber ◽  
Charles Chazot ◽  
Joel D. Kopple
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Trace Element

Association between trace element concentrations and anemia in patients with chronic kidney disease: a cross-sectional population-based study

2019 ◽  
Vol 67 (6) ◽  
pp. 995-1001 ◽  
Author(s):  
Chi-Feng Pan ◽  
Cheng-Jui Lin ◽  
Shu-Hua Chen ◽  
Chi-Feng Huang ◽  
Chun-Chuan Lee
Keyword(s):  
Chronic Kidney Disease ◽  
Trace Elements ◽  
Kidney Disease ◽  
Trace Element ◽  
Iron Concentration ◽  
Population Based ◽  
Cross Sectional ◽  
Total Study Population ◽  
Element Concentrations ◽  
Zinc Cadmium

Anemia is common in chronic kidney disease (CKD) and may be affected by trace element concentrations. While the concentrations of trace elements are known to be altered in CKD, the relationship between trace element and hemoglobin concentrations has not been systematically investigated in a large cohort. This study aims to examine associations between trace element concentrations and anemia in patients with CKD. Data from the National Health and Nutrition Examination Survey collected from 2011 to 2014 were used for this analysis. The participants who were more than 20 years old were included. A total of 3057 participants were included; the final cohort was divided into two groups based on CKD status. The concentrations of hemoglobin, iron, zinc, and manganese were significantly lower in participants with than without CKD (all p<0.05). Multivariate analyses showed that in patients without CKD, hemoglobin concentrations correlated positively with iron, zinc, and cadmium (β=0.005, 0.009, and 0.33, respectively), but correlated negatively with copper levels (β=−0.002). In patients with CKD, hemoglobin concentrations correlated positively with cadmium and selenium, but negatively with copper levels (β=0.57, 0.007, and −0.008, respectively). The serum iron concentration was found to correlate positively with zinc, cadmium, and selenium, but negatively with copper and manganese concentrations in the total study population (all p<0.05). The associations between serum concentrations of trace elements and hemoglobin differ between patients with and without CKD. Further investigations are warranted to determine whether patients with CKD have distinct trace element requirements.

Principles responsible for trace element concentrations in chronic kidney disease

2021 ◽  
Author(s):  
Guido Filler ◽  
Yi Qiu ◽  
Frederick Kaskel ◽  
Christopher William McIntyre
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Trace Element ◽  
Element Concentrations

scholarly journals Vitamin and trace element concentrations in infants and children with chronic kidney disease

2020 ◽  
Vol 35 (8) ◽  
pp. 1463-1470
Author(s):  
Triona Joyce ◽  
Pernille Rasmussen ◽  
Nabil Melhem ◽  
Joanna Clothier ◽  
Caroline Booth ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Trace Element ◽  
Infants And Children ◽  
Element Concentrations ◽  
In Infants And Children
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