Association between trace element concentrations and anemia in patients with chronic kidney disease: a cross-sectional population-based study

2019 ◽  
Vol 67 (6) ◽  
pp. 995-1001 ◽  
Author(s):  
Chi-Feng Pan ◽  
Cheng-Jui Lin ◽  
Shu-Hua Chen ◽  
Chi-Feng Huang ◽  
Chun-Chuan Lee
Keyword(s):  
Chronic Kidney Disease ◽  
Trace Elements ◽  
Kidney Disease ◽  
Trace Element ◽  
Iron Concentration ◽  
Population Based ◽  
Cross Sectional ◽  
Total Study Population ◽  
Element Concentrations ◽  
Zinc Cadmium

Anemia is common in chronic kidney disease (CKD) and may be affected by trace element concentrations. While the concentrations of trace elements are known to be altered in CKD, the relationship between trace element and hemoglobin concentrations has not been systematically investigated in a large cohort. This study aims to examine associations between trace element concentrations and anemia in patients with CKD. Data from the National Health and Nutrition Examination Survey collected from 2011 to 2014 were used for this analysis. The participants who were more than 20 years old were included. A total of 3057 participants were included; the final cohort was divided into two groups based on CKD status. The concentrations of hemoglobin, iron, zinc, and manganese were significantly lower in participants with than without CKD (all p<0.05). Multivariate analyses showed that in patients without CKD, hemoglobin concentrations correlated positively with iron, zinc, and cadmium (β=0.005, 0.009, and 0.33, respectively), but correlated negatively with copper levels (β=−0.002). In patients with CKD, hemoglobin concentrations correlated positively with cadmium and selenium, but negatively with copper levels (β=0.57, 0.007, and −0.008, respectively). The serum iron concentration was found to correlate positively with zinc, cadmium, and selenium, but negatively with copper and manganese concentrations in the total study population (all p<0.05). The associations between serum concentrations of trace elements and hemoglobin differ between patients with and without CKD. Further investigations are warranted to determine whether patients with CKD have distinct trace element requirements.

scholarly journals Trace Elements and Chronic Kidney Disease: A Cross-Sectional Study from Jamaica

2021 ◽  
pp. 79-90
Author(s):  
Adwalia Fevrier-Paul ◽  
Adedamola Soyibo ◽  
Nimal De Silva ◽  
Sylvia Mitchell ◽  
Donovan McGrowder ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Trace Elements ◽  
Kidney Disease ◽  
Trace Element ◽  
Kidney Function ◽  
Inductively Coupled Plasma ◽  
Trace Element Analysis ◽  
Area Under The Curve ◽  
Element Analysis ◽  
Cross Sectional

Background: Several environmental studies have reported that low-level exposure to nephrotoxic elements increases the risk of chronic kidney disease (CKD). In developing countries, finite resources can limit epidemiological studies and environmental risk assessment; however, the unique soil profile in Jamaica has raised some concerns for the potential exposure to populations who are of high risk. Method: This study investigated the potential for using trace element profiling in CKD, by analysing blood concentration levels of vanadium, chromium, iron, cobalt, copper, zinc, selenium, strontium (Sr), arsenic, barium, cadmium, mercury, and lead. Trace element analysis was conducted using inductively coupled plasma mass spectrometry. Results: One hundred and fifty-eight individuals were included and were predominantly of African descent (98%) and their ages ranged from 21 to 90 years old. Three main correlation clusters were evident: firstly, vanadium, chromium, copper, silicon, and selenium, with mercury and barium more distantly related; secondly, lead, arsenic, nickel, and Sr; and thirdly, iron and zinc. Cadmium was an outlier. Blood Sr was strongly associated with estimated glomerular filtration rate (r = -0.83; p<0.001) and strong linear progression models (r2=0.96; p<0.001). Algorithmic models placed Sr as the highest-ranking trace element biomarker (area under the curve: 95.6%; p<0.001). Discussion: The decline in kidney function may result in the retention of non-essential trace elements. Strong corresponding trends between kidney function and blood Sr concentration indicate biomarker potential for a trace element with a unique profile in patients with CKD. Other significant relationships may also be unveiled as CKD biomarkers as trace element profiling is explored in the region.

scholarly journals Prevalence of chronic kidney disease and its associated factors in Malaysia; findings from a nationwide population-based cross-sectional study

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Thamil Arasu Saminathan ◽  
Lai Seong Hooi ◽  
Muhammad Fadhli Mohd Yusoff ◽  
Loke Meng Ong ◽  
Sunita Bavanandan ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Associated Factors ◽  
Population Based ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional

scholarly journals Determinants and burden of chronic kidney disease in the population-based CoLaus study: a cross-sectional analysis*

2013 ◽  
Vol 28 (9) ◽  
pp. 2329-2339 ◽  
Author(s):  
Belén Ponte ◽  
Menno Pruijm ◽  
Pedro Marques-Vidal ◽  
Pierre-Yves Martin ◽  
Michel Burnier ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Population Based ◽  
Cross Sectional ◽  
Cross Sectional Analysis ◽  
Sectional Analysis

scholarly journals Prevalence of impaired renal function and determinants in the southwest of Iran

2021 ◽  
Author(s):  
Saba Alvand ◽  
Farhad Abolnezhadian ◽  
Sudabeh Alatab ◽  
Zahra Mohammadi ◽  
Fatemeh Hayati ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Strong Association ◽  
Density Lipoprotein ◽  
Population Based ◽  
Cross Sectional Study ◽  
Stage Iii ◽  
Health Study ◽  
Cross Sectional ◽  
Ckd Stage

Abstract Background: Chronic kidney disease (CKD) is a growing global health problem with faster progression in developing countries such as Iran. Here we aimed to evaluate the prevalence and determinants of CKD stage III+.Methods: This research is part of the Khuzestan Comprehensive Health Study (KCHS), a large observational population-based cross-sectional study in which 30041 participants aged 20 to 65 were enrolled. CKD was determined with estimated glomerular filtration rate (eGFR) less than 60 ml/min/1.73m2, based on two equations of Modification of Diet in Renal Disease (MDRD) and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI). The multivariate logistic regression was used to evaluate the CKD stage III+ determinants.Results: Prevalence of CKD stage III+ is estimated to be 7.1 %, 5.5%, and 5.4% based on MDRD, CKD-EPI, and combination of both equations, respectively. More than 89% of CKD subjects aged higher than 40 years. In regression analysis, age more than 40 years had the strongest association with CKD stage III+ probability (OR: 8.23, 95% CI: 6.91-9.18). Higher wealth score, hypertension, High-Density Lipoprotein levels less than 40 mg/dl, and higher waist to hip ratio were all associated with CKD stage III+ while Arab ethnicity showed a protective effect (OR: 0.69, 95% CI: 0.57-0.78). Conclusion: Our findings provide detailed information on the CKD stage III+ and its determinants in the southwest region of Iran. Due to strong association between age and CKD stage III+, within a few decades we might expect a huge rise in the CKD prevalence.

scholarly journals Obesity and Its Relation to Chronic Kidney Disease: A Population-Based, Cross-Sectional Study of a Thai Population

2012 ◽  
Vol 31 (2) ◽  
pp. A71
Author(s):  
Bancha Satirapoj ◽  
Ouppatham Supasyndh ◽  
Amnart Chaiprasert ◽  
Prajej Ruangkanchanasetr ◽  
Naowanit Nata ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Population Based ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Thai Population ◽  
Cross Sectional

scholarly journals Prevalence of chronic kidney disease in the community using data from OxRen: a UK population-based cohort study

2020 ◽  
Vol 70 (693) ◽  
pp. e285-e293 ◽  
Author(s):  
Jennifer A Hirst ◽  
Nathan Hill ◽  
Chris A O’Callaghan ◽  
Daniel Lasserson ◽  
Richard J McManus ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Renal Function ◽  
Cohort Study ◽  
Kidney Disease ◽  
Population Based ◽  
Screening Tests ◽  
Rapid Progression ◽  
Age Group ◽  
Baseline Assessment ◽  
Cross Sectional

BackgroundChronic kidney disease (CKD) is a largely asymptomatic condition of diminished renal function, which may not be detected until advanced stages without screening.AimTo establish undiagnosed and overall CKD prevalence using a cross-sectional analysis.Design and settingLongitudinal cohort study in UK primary care.MethodParticipants aged ≥60 years were invited to attend CKD screening visits to determine whether they had reduced renal function (estimated glomerular filtration rate [eGFR] <60 ml/min/1.73 m2 or albumin:creatinine ratio ≥3 mg/mmol). Those with existing CKD, low eGFR, evidence of albuminuria, or two positive screening tests attended a baseline assessment (CKD cohort).ResultsA total of 3207 participants were recruited and 861 attended the baseline assessment. The CKD cohort consisted of 327 people with existing CKD, 257 people with CKD diagnosed through screening (CKD prevalence of 18.2%, 95% confidence interval [CI] = 16.9 to 19.6), and 277 with borderline/transient decreased renal function. In the CKD cohort, 54.4% were female, mean standard deviation (SD) age was 74.0 (SD 6.9) years, and mean eGFR was 58.0 (SD 18.4) ml/min/1.73 m2. Of the 584 with confirmed CKD, 44.0% were diagnosed through screening. Over half of the CKD cohort (51.9%, 447/861) fell into CKD stages 3–5 at their baseline assessment, giving an overall prevalence of CKD stages 3–5 of 13.9% (95% CI = 12.8 to 15.1). More people had reduced eGFR using the Modification of Diet in Renal Disease (MDRD) equation than with CKD Epidemiology Collaboration (CKD-EPI) equation in the 60–75-year age group and more had reduced eGFR using CKD-EPI in the ≥80-year age group.ConclusionThis study found that around 44.0% of people living with CKD are undiagnosed without screening, and prevalence of CKD stages 1–5 was 18.2% in participants aged >60 years. Follow-up will provide data on annual incidence, rate of CKD progression, determinants of rapid progression, and predictors of cardiovascular events.

scholarly journals Prevalence of Chronic Kidney Disease (CKD) and Identification of Associated Risk Factors among Rural Population by Mass Screening

2013 ◽  
Vol 1 (1) ◽  
pp. 20-26 ◽  
Author(s):  
Mahmud Javed Hasan ◽  
M Abul Kashem ◽  
M Hasibur Rahman ◽  
Ruhul Qudduhush ◽  
Masudur Rahman ◽  
...  
Keyword(s):  
Risk Factors ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Serum Creatinine ◽  
Rural Population ◽  
Smoking Habit ◽  
Population Based ◽  
Clinical Variable ◽  
Cross Sectional ◽  
Associated Risk Factors

The prevalence of Chronic Kidney Disease (CKD) is rapidly increasing worldwide. Population-based studies on the prevalence of kidney damage are limited in developing countries. The present work relates to a population-based screening study in a rural population. Objectives: The study was performed to investigate the prevalence of chronic kidney disease (CKD) in rural residents and find out the association of the associated risk factors and variables. Methods: This is a descriptive cross sectional study. The demographic variables included were age, sex, marital status, religion, occupation, socioeconomic status, monthly income. The clinical variable was hypertension. The risk factors under the study were Body Mass Index (BMI), smoking habit, hypertension, and diabetes mellitus. Data pertaining to biochemical investigations were urine for albumin, serum creatinine and random serum glucose. CKD suspected patients were subjected to repeat serum creatinine and urinary albumin testing three months after the initial testing to confirm diagnosis of true CKD. Results: 1240 patients of which 650 were males and 590 females, aged between 18 and 65 years were entered into this study. The result evidenced over-all CKD prevalence 19 % determined by Cockcroft-Gault and 19.5 % MDRD equations. Stage 3 CKD was found to be predominant in both Cockcroft-Gault (12.8%) and MDRD equations (13.2%). The risk factors were thought to be associated with CKD which demonstrated association with hypertension (19.3%), diabetes (4.9%) and others (1.3%). A total of 206(88%) patients determined by Cockcroft-Gault and 210 (89.4%) by MDRD equations were diagnosed as having CKD in 2nd follow up visit (3 months after the 1st visit). Conclusion: It appears from this study that one out of three people in this population at risk remained undiag-nosed as CKD and with poorly controlled CKD risk factors. This is a growing problem and a challenge to this country. On priority basis CKD needs to be addressed through the development of multidisciplinary health teams and establishment of improved communication between traditional health care givers and nephrology services. DOI: http://dx.doi.org/10.3329/cbmj.v1i1.13825 Community Based Medical Journal Vol.1(1) 2012 20-26

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