scholarly journals Does the choice of phosphate binder affect trace element levels in chronic kidney disease patients treated by regular haemodialysis?

2010 ◽  
Vol 26 (3) ◽  
pp. 1006-1010 ◽  
Author(s):  
K. Veighey ◽  
J. Booth ◽  
A. Davenport
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Trace Element ◽  
Phosphate Binder ◽  
Trace Element Levels

Evaluating Sucralfate as a Phosphate Binder in Normal Cats and Cats with Chronic Kidney Disease

2016 ◽  
Vol 52 (1) ◽  
pp. 8-12 ◽  
Author(s):  
Jessica Quimby ◽  
Michael Lappin
Keyword(s):  
Chronic Kidney Disease ◽  
Side Effects ◽  
Kidney Disease ◽  
Urinary Excretion ◽  
Phosphate Binder ◽  
Fractional Excretion ◽  
Serum Phosphorus ◽  
Phosphorus Concentration ◽  
Apparent Lack ◽  
Fecal Phosphorus

Control of hyperphosphatemia is an important part of the management of chronic kidney disease (CKD). The purpose of this study was to determine the efficacy of sucralfate as a phosphate binder in normal cats and normophosphatemic CKD cats. A 500 mg sucralfate slurry was administered orally q 8 hr for 2 wk, and serum phosphorus, urine fractional excretion of phosphorus, and fecal phosphorus concentrations were measured. In normal cats treated with sucralfate, significant changes in serum phosphorus concentration or urinary excretion of phosphorus were not detected, and vomiting occurred after 14.7% of administrations. Of the five normophosphatemic cats with CKD treated with sucralfate, three experienced clinical decompensation, including vomiting, anorexia, constipation, and increased azotemia. Administration of sucralfate did not result in significant changes in fecal phosphorus concentration in these cats. The effects of sucralfate administration on serum phosphorus concentration and urinary excretion of phosphorus in CKD cats was difficult to determine because of dehydration and worsening azotemia associated with decompensation. Due to side effects and the apparent lack of efficacy of the medication, the study was discontinued. This study was unable to confirm efficacy of this sucralfate formulation as a phosphate binder, and side effects were problematic during the study.

scholarly journals Trace Elements and Chronic Kidney Disease: A Cross-Sectional Study from Jamaica

2021 ◽  
pp. 79-90
Author(s):  
Adwalia Fevrier-Paul ◽  
Adedamola Soyibo ◽  
Nimal De Silva ◽  
Sylvia Mitchell ◽  
Donovan McGrowder ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Trace Elements ◽  
Kidney Disease ◽  
Trace Element ◽  
Kidney Function ◽  
Inductively Coupled Plasma ◽  
Trace Element Analysis ◽  
Area Under The Curve ◽  
Element Analysis ◽  
Cross Sectional

Background: Several environmental studies have reported that low-level exposure to nephrotoxic elements increases the risk of chronic kidney disease (CKD). In developing countries, finite resources can limit epidemiological studies and environmental risk assessment; however, the unique soil profile in Jamaica has raised some concerns for the potential exposure to populations who are of high risk. Method: This study investigated the potential for using trace element profiling in CKD, by analysing blood concentration levels of vanadium, chromium, iron, cobalt, copper, zinc, selenium, strontium (Sr), arsenic, barium, cadmium, mercury, and lead. Trace element analysis was conducted using inductively coupled plasma mass spectrometry. Results: One hundred and fifty-eight individuals were included and were predominantly of African descent (98%) and their ages ranged from 21 to 90 years old. Three main correlation clusters were evident: firstly, vanadium, chromium, copper, silicon, and selenium, with mercury and barium more distantly related; secondly, lead, arsenic, nickel, and Sr; and thirdly, iron and zinc. Cadmium was an outlier. Blood Sr was strongly associated with estimated glomerular filtration rate (r = -0.83; p<0.001) and strong linear progression models (r2=0.96; p<0.001). Algorithmic models placed Sr as the highest-ranking trace element biomarker (area under the curve: 95.6%; p<0.001). Discussion: The decline in kidney function may result in the retention of non-essential trace elements. Strong corresponding trends between kidney function and blood Sr concentration indicate biomarker potential for a trace element with a unique profile in patients with CKD. Other significant relationships may also be unveiled as CKD biomarkers as trace element profiling is explored in the region.

Vitamin and Trace Element Needs in Chronic Kidney Disease

2020 ◽  
pp. 607-623
Author(s):  
Alison L. Steiber ◽  
Charles Chazot ◽  
Joel D. Kopple
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Trace Element

Practice patterns of phosphate binder use and their associations with mortality in chronic kidney disease

2014 ◽  
Author(s):  
Sankar D. Navaneethan ◽  
Ankit Sakhuja ◽  
Susana Arrigain ◽  
John Sharp ◽  
Jesse D. Schold ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Phosphate Binder ◽  
Practice Patterns
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