Ischemia-Reperfusion Injury and Therapeutic Strategy in Donation After Circulatory Death Liver Transplantation

2020 ◽  
pp. 73-86
Author(s):  
Toru Goto ◽  
Markus Selzner
Keyword(s):  
Liver Transplantation ◽  
Reperfusion Injury ◽  
Therapeutic Strategy ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Donation After Circulatory Death ◽  
Circulatory Death

scholarly journals Donor hepatectomy time influences ischemia-reperfusion injury of the biliary tree in donation after circulatory death liver transplantation

Surgery ◽  
2020 ◽  
Vol 168 (1) ◽  
pp. 160-166 ◽  
Author(s):  
Otto B. van Leeuwen ◽  
Marjolein van Reeven ◽  
Danny van der Helm ◽  
Jan N.M. IJzermans ◽  
Vincent E. de Meijer ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Biliary Tree ◽  
Donation After Circulatory Death ◽  
Donor Hepatectomy ◽  
Circulatory Death

scholarly journals CORM-401 Reduces Ischemia Reperfusion Injury in an Ex Vivo Renal Porcine Model of the Donation After Circulatory Death

2018 ◽  
Vol 102 (7) ◽  
pp. 1066-1074 ◽  
Author(s):  
Rabindra N. Bhattacharjee ◽  
Mahms Richard-Mohamed ◽  
Qizhi Sun ◽  
Aaron Haig ◽  
Ghaleb Aboalsamh ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Porcine Model ◽  
Ischemia Reperfusion Injury ◽  
Ex Vivo ◽  
Ischemia Reperfusion ◽  
Donation After Circulatory Death ◽  
Circulatory Death

Sildenafil Citrate in a Donation After Circulatory Death Experimental Model of Renal Ischemia-Reperfusion Injury

2014 ◽  
Vol 98 (6) ◽  
pp. 612-617 ◽  
Author(s):  
Sarah A. Hosgood ◽  
Lucy V. Randle ◽  
Meeta Patel ◽  
Christopher J. Watson ◽  
John A. Bradley ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Experimental Model ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Renal Ischemia ◽  
Sildenafil Citrate ◽  
Donation After Circulatory Death ◽  
Renal Ischemia Reperfusion Injury ◽  
Circulatory Death

scholarly journals Impact of Three Methods of Ischemic Preconditioning on Ischemia-Reperfusion Injury in a Pig Model of Liver Transplantation

2021 ◽  
pp. 1-10
Author(s):  
Alessandro Rodrigo Belon ◽  
Ana Cristina Aoun Tannuri ◽  
Daniel de Albuquerque Rangel Moreira ◽  
Jose Luiz Figueiredo ◽  
Alessandra Matheus da Silva ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Reperfusion Injury ◽  
Ischemic Preconditioning ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Pig Model

scholarly journals Reducing Cardiac Injury during ST-Elevation Myocardial Infarction: A Reasoned Approach to a Multitarget Therapeutic Strategy

2021 ◽  
Vol 10 (13) ◽  
pp. 2968
Author(s):  
Alessandro Bellis ◽  
Giuseppe Di Gioia ◽  
Ciro Mauro ◽  
Costantino Mancusi ◽  
Emanuele Barbato ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Reperfusion Injury ◽  
Therapeutic Strategy ◽  
Ventricular Remodeling ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Left Ventricular ◽  
St Elevation Myocardial Infarction ◽  
Ischemic Time ◽  
St Elevation

The significant reduction in ‘ischemic time’ through capillary diffusion of primary percutaneous intervention (pPCI) has rendered myocardial-ischemia reperfusion injury (MIRI) prevention a major issue in order to improve the prognosis of ST elevation myocardial infarction (STEMI) patients. In fact, while the ischemic damage increases with the severity and the duration of blood flow reduction, reperfusion injury reaches its maximum with a moderate amount of ischemic injury. MIRI leads to the development of post-STEMI left ventricular remodeling (post-STEMI LVR), thereby increasing the risk of arrhythmias and heart failure. Single pharmacological and mechanical interventions have shown some benefits, but have not satisfactorily reduced mortality. Therefore, a multitarget therapeutic strategy is needed, but no univocal indications have come from the clinical trials performed so far. On the basis of the results of the consistent clinical studies analyzed in this review, we try to design a randomized clinical trial aimed at evaluating the effects of a reasoned multitarget therapeutic strategy on the prevention of post-STEMI LVR. In fact, we believe that the correct timing of pharmacological and mechanical intervention application, according to their specific ability to interfere with survival pathways, may significantly reduce the incidence of post-STEMI LVR and thus improve patient prognosis.

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