Intestinal Fluid Handling: Absorption

This research aim to validation of a simple, rapid and accurate HPLC-UV method for the quantification of andrographolide isolated from Andrographis paniculata Ness in Self Nano Emulsifying Drug Delivery System (SNEDDS) formulation during the dissolution test. The assay was performed using a XTerra® MS C18 column (150 mm X 4.6 mm, five μm) with a mobile phase of methanol and water (70: 30), at 0.8 mL/min flow rate and UV detection of 229 nm. Simulation gastric fluid (SGF) and intestinal fluid (SIF) were prepared as dissolution medium. The validation parameter was conducted including the test on linearity, precision, accuracy, LOD, and LOQ. The result showed an excellent linearity with r = 0.999 and good selectivity for both medium dissolution. The method showed sufficient precision, with a relative standard deviation (RSD) smaller than % Horwitz. The accuracy reported as % recovery was found to be 102.61 and 101.17 % in each SGF and SIF dissolution medium. LOD and LOQ were found 0.46 and 1.40 in SGF medium, 0.87 and 2.64 in SIF medium. In conclusion, the HPLC method developed showed specificity and selectivity with linearity in the working range, good precision and accuracy and suitable for quantification andrographolide in SNEDDS formulation.

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Faculty Opinions recommendation of Lectin conjugates as potent, nonabsorbable CFTR inhibitors for reducing intestinal fluid secretion in cholera.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1078787.531713 ◽

2007 ◽

Author(s):

Richard J Naftalin

Keyword(s):

Fluid Secretion ◽

Intestinal Fluid ◽

Intestinal Fluid Secretion

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Epoxy\Epoxy Composite\Epoxy Hybrid Composite Coatings for Tribological Applications—A Review

Polymers ◽

10.3390/polym13020179 ◽

2021 ◽

Vol 13 (2) ◽

pp. 179

Author(s):

M. M. A. Baig ◽

M. Abdul Samad

Keyword(s):

Tribological Properties ◽

Hybrid Composite ◽

Review Paper ◽

Epoxy Composite ◽

Composite Coatings ◽

Load Bearing Capacity ◽

Corrosive Media ◽

Fluid Handling ◽

Low Load ◽

Made In

Epoxy composite coating systems generally find their usage in applications such as, fluid handling systems to protect components from corrosive media. However, their use in demanding tribological applications such as, in sliding components of machines, are known to be limited. This is often attributed to their low load bearing capacity combined with poor thermal stability under severe p-v regimes. Researchers have tried to enhance the tribological properties of the epoxy coatings using a combination of several types of micro/nano sized fillers to produce composite or hybrid composite coatings. Hence, this review paper aims to focus on the recent advances made in developing the epoxy coating systems. Special attention would be paid to the types and properties of nano-fillers that have been commonly used to develop these coatings, different dispersion techniques adopted and the effects that each of these fillers (and their combinations) have on the tribological properties of these coatings.

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