From Tubes and Catheters to the Basis of Hemodynamics: Viscosity and Hagen–Poiseuille Equation

Author(s):  
Antonio Pisano
Keyword(s):  
1993 ◽  
Vol 265 (4) ◽  
pp. R715-R720 ◽  
Author(s):  
R. S. Seymour ◽  
A. R. Hargens ◽  
T. J. Pedley

The circulatory systems of vertebrate animals are closed, and blood leaves and returns to the heart at the same level. It is often concluded, therefore, that the heart works only against the viscous resistance of the system, not against gravity, even in vascular loops above the heart in which the siphon principle operates. However, we argue that the siphon principle does not assist blood flow in superior vascular loops if any of the descending vasculature is collapsible. If central arterial blood pressure is insufficient to support a blood column between the heart and the head, blood flow ceases because of vascular collapse. Furthermore, the siphon principle does not assist the heart even when a continuous stream of blood is flowing in a superior loop. The potential energy gained by blood as it is pumped to the head is lost to friction in partially collapsed descending vessels and thus is not regained. Application of the Poiseuille equation to flow in collapsible vessels is limited; resistance depends on flow rate in partially collapsed vessels with no transmural pressure difference, but flow rate is independent of resistance. Thus the pressure developed by the heart to establish a given flow rate is independent of the resistance occurring in the partially collapsed vessels. The pressure depends only on the height of the blood column and the resistance in the noncollapsed parts of the system. Simple laboratory models, involving water flow in collapsible tubing, dispel the idea that the siphon principle facilitates blood flow and suggest that previously published results may have been affected by experimental artifact.


Author(s):  
Edward Gilbert-Kawai ◽  
Marc Wittenberg

Author(s):  
Felix Fischer ◽  
Julian Bartz ◽  
Katharina Schmitz ◽  
Ludwig Brouwer ◽  
Hubert Schwarze

The dynamic viscosity of a fluid is an important input parameter for the investigation of elastohydrodynamic contacts within tribological simulation tools. In this paper, a capillary viscometer is used to analyse the viscosity of a calibration fluid for diesel injection pumps. Capillary viscometers are often used for the determination of viscosities that show a significant dependence on shear rate, pressure and temperature such as polymer melts or blood. Therefore most of the research on corrections of measured viscosities have been made using polymer melts. A new method is presented to shorten the effort in evaluating the capillary experiment. The viscosity itself can be calculated from experimental data. Essential parameters are the radius of the capillary, its length, the capillary flow and the pressure difference over the capillary. These quantities are used in the Hagen-Poiseuille equation to calculate the viscosity, assuming laminar and monodirectional flow. According to said equation, the viscosity depends on the geometry and the pressure gradient. A typical capillary viscometer contains three main flow irregularities. First the contraction of the flow at the capillary inlet, second the expansion of the flow at the capillary outlet and third the inlet section length of the flow after which the velocity profile is fully developed. These flow phenomena cause pressure losses, which have to be taken into account, as well as the altered length of the laminar flow in the capillary. Furthermore, the temperature difference over the capillary also affects the outlet flow. Therefore, in this paper, a newly developed method is proposed, which shortens the effort in pressure and length correction. The method is valid for viscometers, which provide a single phase flow of the sampling fluid. Furthermore, the proposed correction is suited for arbitrary geometries. A numerical approach is chosen for the analysis of the experiment. In order to facilitate the experimental procedure of a capillary viscometer, a special algorithm was developed. The numerical approach uses a static CFD simulation, which is recursively passed through. If a termination condition, regarding the pressure difference between two cycles, is fulfilled, the real viscosity can be calculated in the usual way from the Hagen-Poiseuille equation. A special advantage of the proposed experimental evaluation is the general applicability for arbitrary geometries. In this paper, the procedure is validated with a well-known reference fluid and compared to data, which was gathered from a quartz viscometer experiment with the same fluid. Therefore, experiments are conducted with the capillary viscometer and compared at various pressure and temperature levels.


1989 ◽  
Vol 27 (8) ◽  
pp. 598-601 ◽  
Author(s):  
Henry S. Badeer ◽  
Costas E. Synolakis
Keyword(s):  

Membranes ◽  
2018 ◽  
Vol 8 (4) ◽  
pp. 90 ◽  
Author(s):  
Olof Gustafsson ◽  
Simon Gustafsson ◽  
Levon Manukyan ◽  
Albert Mihranyan

Pressure-dependent breakthrough of nanobioparticles in filtration was observed and it was related to depend on both convective forces due to flow and diffusion as a result of Brownian motion. The aim of this work was to investigate the significance of Brownian motion on nanoparticle and virus capture in a nanocellulose-based virus removal filter paper through theoretical modeling and filtration experiments. Local flow velocities in the pores of the filter paper were modeled through two different approaches (i.e., with the Hagen–Poiseuille equation) and by evaluating the superficial linear flow velocity through the filter. Simulations by solving the Langevin equation for 5 nm gold particles and 28 nm ΦX174 bacteriophages showed that hydrodynamic constraint is favored for larger particles. Filtration of gold nanoparticles showed no difference in retention for the investigated fluxes, as predicted by the modeling of local flow velocities. Filtration of ΦX174 bacteriophages exhibited a higher retention at higher filtration pressure, which was predicted to some extent by the Hagen–Poiseuille equation but not by evaluation of the superficial linear velocity. In all, the hydrodynamic theory was shown able to explain some of the observations during filtration.


Sign in / Sign up

Export Citation Format

Share Document