scholarly journals Characterizing Myocardial Ischemia and Reperfusion Patterns with Hierarchical Manifold Learning

2022 ◽  
pp. 66-74
Author(s):  
Benoît Freiche ◽  
Patrick Clarysse ◽  
Magalie Viallon ◽  
Pierre Croisille ◽  
Nicolas Duchateau
Keyword(s):  
Myocardial Ischemia ◽  
Manifold Learning ◽  
Ischemia And Reperfusion ◽  
Myocardial Ischemia And Reperfusion

In Vivo MRI Visualization of Acute Myocardial Ischemia and Reperfusion in Ferrets by the Persistent Action of the Contrast Agent Gd(BME-DTTA)

Circulation ◽  
1995 ◽  
Vol 92 (12) ◽  
pp. 3549-3559 ◽  
Author(s):  
Tamás Simor ◽  
Wen-Jang Chu ◽  
Lynne Johnson ◽  
Andras Safranko ◽  
Mark Doyle ◽  
...  
Keyword(s):  
Myocardial Ischemia ◽  
Contrast Agent ◽  
Acute Myocardial Ischemia ◽  
Ischemia And Reperfusion ◽  
Myocardial Ischemia And Reperfusion

scholarly journals Activation of signaling pathways and regulatory mechanisms of mRNA translation following myocardial ischemia-reperfusion

2006 ◽  
Vol 101 (2) ◽  
pp. 576-582 ◽  
Author(s):  
Stephen J. Crozier ◽  
Xueqian Zhang ◽  
Jufang Wang ◽  
Joseph Cheung ◽  
Scot R. Kimball ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Myocardial Ischemia ◽  
Protein Expression ◽  
Signaling Pathways ◽  
Mrna Translation ◽  
Mitogen Activated Protein Kinase ◽  
Regulatory Mechanisms ◽  
Ischemia And Reperfusion ◽  
Myocardial Ischemia And Reperfusion ◽  
Mitogen Activated Protein

Protein expression in the heart is altered following periods of myocardial ischemia. The changes in protein expression are associated with increased cell size that can be maladaptive. There is little information regarding the regulation of protein expression through the process of mRNA translation during ischemia and reperfusion in the heart. Therefore, the purpose of this study was to identify changes in signaling pathways and downstream regulatory mechanisms of mRNA translation in an in vivo model of myocardial ischemia and reperfusion. Hearts were collected from rats whose left main coronary arteries had either been occluded for 25 min or reversibly occluded for 25 min and subsequently reperfused for 15 min. Following reperfusion, both the phosphoinositide 3-kinase and mitogen-activated protein kinase pathways were activated, as evidenced by increased phosphorylation of Akt (PKB), extracellular signal-regulated kinase 1/2, and p38 mitogen-activated protein kinase. Activation of Akt stimulated signaling through the protein kinase mammalian target of rapamycin, as evidenced by increased phosphorylation of two of its effectors, the ribosomal protein S6 kinase and the eukaryotic initiation factor eIF4E binding protein 1. Ischemia and reperfusion also resulted in increased phosphorylation of eIF2 and eIF2B. These changes in protein phosphorylation suggest that control of mRNA translation following ischemia and reperfusion is modulated through a number of signaling pathways and regulatory mechanisms.

scholarly journals Oedema, detected by T1 mapping, is detectible early and remains constant following brief myocardial ischemia and reperfusion in a rat model

2013 ◽  
Vol 34 (suppl 1) ◽  
pp. P5363-P5363
Author(s):  
D. O H-Ici ◽  
S. Jeuthe ◽  
S. Kozerke ◽  
H. Pietsch ◽  
T. Kuehne ◽  
...  
Keyword(s):  
Myocardial Ischemia ◽  
Rat Model ◽  
T1 Mapping ◽  
Ischemia And Reperfusion ◽  
Myocardial Ischemia And Reperfusion

scholarly journals Regional changes in blood flow, extracellular potassium and conduction during myocardial ischemia and reperfusion

1993 ◽  
Vol 21 (3) ◽  
pp. 798-808 ◽  
Author(s):  
Robert J. Hariman ◽  
Eric K. Louie ◽  
Rick L. Krahmer ◽  
Siobhan M. Bremner ◽  
David Euler ◽  
...  
Keyword(s):  
Blood Flow ◽  
Myocardial Ischemia ◽  
Extracellular Potassium ◽  
Ischemia And Reperfusion ◽  
Myocardial Ischemia And Reperfusion
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