Pseudopeptide Analogs of Bradykinin and Bradykinin Antagonists

1992 ◽  
pp. 565-571 ◽  
Author(s):  
Raymond J. Vavrek ◽  
Lajos Gera ◽  
John M. Stewart
Keyword(s):  
Bradykinin Antagonists

scholarly journals Discovery of a Bradykinin B2 Partial Agonist Profile of Raloxifene in a Drug Repurposing Campaign

2020 ◽  
Vol 22 (1) ◽  
pp. 257
Author(s):  
Patricia Gomez-Gutierrez ◽  
Juan J. Perez
Keyword(s):  
Virtual Screening ◽  
Molecular Mechanisms ◽  
Partial Agonist ◽  
Drug Repurposing ◽  
Cytokine Storm ◽  
Bradykinin Receptors ◽  
Screening Process ◽  
Bradykinin Antagonists ◽  
Illness Progression

Covid-19 urges a deeper understanding of the underlying molecular mechanisms involved in illness progression to provide a prompt therapeutical response with an adequate use of available drugs, including drug repurposing. Recently, it was suggested that a dysregulated bradykinin signaling can trigger the cytokine storm observed in patients with severe Covid-19. In the scope of a drug repurposing campaign undertaken to identify bradykinin antagonists, raloxifene was identified as prospective compound in a virtual screening process. The pharmacodynamics profile of raloxifene towards bradykinin receptors is reported in the present work, showing a weak selective partial agonist profile at the B2 receptor. In view of this new profile, its possible use as a therapeutical agent for the treatment of severe Covid-19 is discussed.

Bradykinin antagonists HOE-440 and CP-0597 diminish microcirculatory injury after ischaemia-reperfusion of the pancreas in rats

1996 ◽  
Vol 83 (2) ◽  
pp. 189-195 ◽  
Author(s):  
T. F. Hoffmann ◽  
R. Leiderer ◽  
H. Waldner ◽  
K. Messmer
Keyword(s):  
Ischaemia Reperfusion ◽  
Bradykinin Antagonists

Potent bradykinin antagonists containing N-benzylglycine or N-benzyl-l-alanine in position 8

2008 ◽  
Vol 63 (1) ◽  
pp. 29-35 ◽  
Author(s):  
O. Dawidowska ◽  
T.H. Wierzba ◽  
A. Prahl ◽  
W. Kowalczyk ◽  
I. Derdowska ◽  
...  
Keyword(s):  
Bradykinin Antagonists

Effect of bradykinin antagonists, and arginine on phospholipase A2 induced oedema in rat paw

1991 ◽  
Vol 22 (5) ◽  
pp. 801-804 ◽  
Author(s):  
Giuseppe Cirino ◽  
Carla Cicala ◽  
Ludovico Sorrentino ◽  
Domenico Regoli
Keyword(s):  
Phospholipase A2 ◽  
Bradykinin Antagonists ◽  
Rat Paw

Bradykinin antagonists containing unusual amino acids show long-lasting action in vivo

Peptides ◽  
1994 ◽  
pp. 449-451
Author(s):  
L. Gera ◽  
V. Srivastava ◽  
F. W. Dunn ◽  
J. M. Stewart
Keyword(s):  
Amino Acids ◽  
Unusual Amino Acids ◽  
Bradykinin Antagonists

Conformational properties of new cyclic bradykinin antagonists

Peptides 1994 ◽  
1995 ◽  
pp. 527-528
Author(s):  
F. Abdelrahim ◽  
L. F. Pineda ◽  
L. Seyfarth ◽  
S. Reissmann ◽  
I. Paegelow
Keyword(s):  
Conformational Properties ◽  
Bradykinin Antagonists
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