Nitric oxide as a mediator of interleukin-2 induced cardiovascular toxicity and antitumor activity

2001 ◽  
pp. 249-272 ◽  
Author(s):  
Wolfram E. Samlowski
Keyword(s):  
Nitric Oxide ◽  
Antitumor Activity ◽  
Interleukin 2 ◽  
Cardiovascular Toxicity

Appraisal of Immunological Impacts of Melaleuca leucadendra Extract over Macrophage Performance in Vitro

2020 ◽  
Keyword(s):  
Nitric Oxide ◽  
Interleukin 2 ◽  
Dependent Manner ◽  
Reduced Pressure ◽  
Medical Plant ◽  
Dose Dependent ◽  
Level Production ◽  
Melaleuca Leucadendra ◽  
Phagocytic Killing

This trial research was performed to discuss the immune-influence of Melaleuca leucadendra ‘paper-bark tree’ dried leaves which is an important medical plant known in many regions in the world. The leaves were dissolved in a mixture of (ethanol + water) (3:1) mixture, then filtered, evaporated and dried under reduced pressure to obtain leaves extract. The macrophages of blood derived origin were provided from rats and mixed with three different leaves extracts doses in tissue culture plates and incubated then stained with fluorescent acridine orange and examined under fluorescent microscope to assess the phagocytic and killing potency. The wells contents were aspirated and assayed for nitric oxide and interleukin-2 levels. The results displayed an obvious increase in phagocytic, killing performance as well as nitric oxide and IL-2 level production than control in a dose dependent manner. The obtained results suggested the immune-stimulant impact of the paper-bark tree leaves.

Structure, nitric oxide (NO) generation and antitumor activity of binuclear tetranitrosyl iron complex with 4-aminothiophenolyl as nitrosyl ferredoxins mimic

2021 ◽  
pp. 1-19
Author(s):  
N.A. Sanina ◽  
G.I. Kozub ◽  
T.A. Kondrat’eva ◽  
T.S. Stupina ◽  
A.A. Balakina ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Antitumor Activity ◽  
Iron Complex

Nitric oxide attenuates interleukin 2-induced lung injury

1997 ◽  
Vol 84 (4) ◽  
pp. 540-542 ◽  
Author(s):  
D. Bouchier-Hayes ◽  
H. Abdih ◽  
C. J. Kelly ◽  
M. Barry ◽  
H. P. Redmond ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Lung Injury ◽  
Interleukin 2

Antitumor Activity of Killer Cells Stimulated with Both Interleukin-2 and Interleukin-12 on Mouse Glioma Cells

1999 ◽  
Vol 22 (3) ◽  
pp. 245-250 ◽  
Author(s):  
Tetsuro Kikuchi ◽  
Tatsuhiro Joki ◽  
Toshiaki Abe ◽  
Tsuneya Ohno
Keyword(s):  
Antitumor Activity ◽  
Interleukin 2 ◽  
Glioma Cells ◽  
Interleukin 12 ◽  
Killer Cells ◽  
Mouse Glioma

scholarly journals Effects of Nitric Oxide NO Synthesis Inhibition on Antitumor Responses during Interleukin-2 IL-2 Treatment of Mice

1996 ◽  
Vol 11 (2) ◽  
pp. 93-100
Author(s):  
Chang Yeol Yim ◽  
Chang Whan Lee ◽  
Soo Mee Choi ◽  
Sang Suk Park ◽  
Sung Joong Lee ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Interleukin 2 ◽  
Synthesis Inhibition

scholarly journals Nitrate Plasma Level as a Marker of Nitric Oxide Production After Subcutaneous Interleukin 2 Immunotherapy

1997 ◽  
Vol 89 (20) ◽  
pp. 1545-1545 ◽  
Author(s):  
C. Porta ◽  
M. Moroni ◽  
E. Bobbio-Pallavicini ◽  
C. Tinelli ◽  
M. Regazzi-Bonora
Keyword(s):  
Nitric Oxide ◽  
Plasma Level ◽  
Interleukin 2 ◽  
Nitric Oxide Production ◽  
Oxide Production

Nitric oxide-independent inhibitory effects of L-arginineanalog NG-monomethy-L-arginine on the generation of interleukin-2 activated cytotoxic activity in humans

1996 ◽  
Vol 15 (1) ◽  
pp. 16-20 ◽  
Author(s):  
A. Juretic ◽  
G.C. Spagnoli ◽  
H. Hörig ◽  
T. Gross ◽  
H. Gallati ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Cytotoxic Activity ◽  
Interleukin 2 ◽  
Inhibitory Effects

A T-cell-selective interleukin 2 mutein exhibits potent antitumor activity and is well tolerated in vivo

10.1038/81199 ◽  
2000 ◽  
Vol 18 (11) ◽  
pp. 1197-1202 ◽  
Author(s):  
Armen B. Shanafelt ◽  
Yue Lin ◽  
Marie-Claude Shanafelt ◽  
Carla P. Forte ◽  
Nathalie Dubois-Stringfellow ◽  
...  
Keyword(s):  
T Cell ◽  
Antitumor Activity ◽  
Interleukin 2
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