Parathyroid Hormones

2016 ◽  
pp. 3523-3538
Author(s):  
Jürgen Sandow
Keyword(s):  
Parathyroid Hormones

EFFECT OF OXIDATION ON BIOLOGICAL AND IMMUNOLOGICAL ACTIVITY OF PORCINE PARATHYROID HORMONE

1974 ◽  
Vol 63 (1) ◽  
pp. 117-124 ◽  
Author(s):  
J. L. H. O'RIORDAN ◽  
J. S. WOODHEAD ◽  
G. N. HENDY ◽  
J. A. PARSONS ◽  
C. J. ROBINSON ◽  
...  
Keyword(s):  
Biological Activity ◽  
Parathyroid Hormone ◽  
Cysteine Oxidation ◽  
Subsequent Reduction ◽  
Immunological Activity ◽  
Parathyroid Hormones ◽  
Methionine Residue

SUMMARY The presence of a single methionine in porcine parathyroid hormone, at position 8, permitted assessment of the role of this residue separate from the second methionine residue found at position 18 of bovine and human parathyroid hormones. Oxidation of the solitary methionine of porcine parathyroid hormone to the sulphoxide destroyed biological activity, but this was restored by subsequent reduction with cysteine. Oxidation of the hormone did not, however, affect its immunological activity; therefore, oxidation of the hormone may bring about dissociation of biological and immunological activity.

The effect of iodosteviol glycoside on hormonal status and the level of proinflammatory cytokines in experimental hypothyroidism

2021 ◽  
Vol 22 (1) ◽  
pp. 14-19
Author(s):  
L. F. Almakaeva ◽  
◽  
G. A. Bajburina ◽  
F. H. Kamilov ◽  
D. Yu. Grebnev ◽  
...  
Keyword(s):  
Blood Plasma ◽  
Inflammatory Cytokines ◽  
Recovery Period ◽  
Experimental Comparison ◽  
Intragastric Administration ◽  
Hormonal Status ◽  
Rebaudioside A ◽  
Parathyroid Hormones ◽  
White Rats ◽  
Pro Inflammatory Cytokines

Aim. Study of the hormonal status and the level of pro-inflammatory cytokines in the blood plasma in experimental hypothyroidism and the effect of the organoiodine complex with rebaudioside A. Materials and methods. Endemic thyroid dysfunction was modeled in sexually mature male white rats by daily intragastric administration of thiamazole for 21 days at a dose of 25 mg / kg. In the blood serum, the content of thyrotropin, total and free thyroxine, total triiodothyronine, testosterone, luteinizing, follicle-stimulating and parathyroid hormones, corticosterone, interleukins-1-beta and -6, tumor necrosis factor-alpha was studied. The animals were divided into four groups of 10 each: control, experimental, comparison and main. Results. The development of hypothyroidism was characterized by an increase in the content of thyroid-stimulating, luteinizing, follicle-stimulating and parathyroid hormones, as well as pro-inflammatory cytokines. At the same time, testosterone levels decreased, while corticosterone levels were within physiological fluctuations. Conclusion. The use within 30 days of the recovery period after the development of hypothyroidism of the iodosaccharide complex based on steviol glycoside rebaudioside A used in the food industry daily at a dose of 25 mg / kg of rat weight led to the normalization of the content of the studied hormones and cytokines in the blood plasma, characterizing the effectiveness of the new organoiodine product.

Effects of Hormones Other than Parathyroid Hormones on Renal Handling of Phosphate

1980 ◽  
pp. 137-195 ◽  
Author(s):  
Eberhard Ritz ◽  
Wilhelm Kreusser ◽  
Jürgen Bommer
Keyword(s):  
Renal Handling ◽  
Parathyroid Hormones

scholarly journals The measurements of parathyroid hormones in sera of elderly osteoporotic patients with serum high alkaline phosphatase activity.

RADIOISOTOPES ◽  
1988 ◽  
Vol 37 (3) ◽  
pp. 163-165
Author(s):  
Kazutami TORIZUMI ◽  
Hirofumi AIBATA ◽  
Yoshiyuki TANIGUCHI ◽  
Shigeyuki KIJI ◽  
Akitaka UEYOSHI ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Phosphatase Activity ◽  
Alkaline Phosphatase Activity ◽  
Parathyroid Hormones

Interaction between antidiuretic and parathyroid hormones on urine concentration

1980 ◽  
Vol 239 (3) ◽  
pp. F244-F249
Author(s):  
H. D. Humes ◽  
C. F. Simmons ◽  
B. M. Brenner
Keyword(s):  
Calcium Ion ◽  
Calcium Concentration ◽  
Urine Concentration ◽  
Sprague Dawley ◽  
Urinary Osmolality ◽  
Group Of Seven ◽  
Parathyroid Hormones ◽  
Sprague Dawley Rats ◽  
Maximum Water ◽  
Solute Excretion

Experiments were performed on 26 acutely thyroparathyroidectomized (TPTX) Sprague-Dawley rats undergoing maximum water diuresis to determine whether the rise in urinary osmolality (Uosmol) in response to a submaximal dose of antidiuretic hormone (ADH) is modified by exogenous administration of parathyroid hormone (PTH). During administration of a submaximal dose of PTH to 11 TPTX rats, the ADH-induced increase in Uosmol averaged 267 +/- 15 mosmol, or twice the average increment of 131 +/- 18 mosmol observed when the same dose of ADH was given prior to PTH infusion (P < 0.001). This difference could not be attributed to changes in endogenous ADH release, renal hemodynamics, or solute excretion, and was not observed in a second group of eight other water-diuretic TPTX rats given sham PTH infusion. A third group of seven water-diuretic TPTX rats were studied with verapamil, a compound known to antagonize calcium ion entry into cells. Pretreatment of these rats with intravenous verapamil abolished the PTH potentiation of the Uosmol response to ADH described above. We conclude, therefore, that PTH enhances the Uosmol response to ADH, perhaps via a mechanism requiring a PTH-mediated change in the cellular calcium concentration or content of cells important in the urinary concentrating process.

Parathyroid Hormones and Phosphate Metabolism

1964 ◽  
Vol 43 (6) ◽  
pp. 1098-1106
Author(s):  
Frederic C. Bartter
Keyword(s):  
Phosphate Metabolism ◽  
Parathyroid Hormones
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