Allograft Dysfunction

2018 ◽  
pp. 837-853
Author(s):  
Carol Conrad ◽  
Nicolaus Schwerk
Keyword(s):  
Allograft Dysfunction

Lung volumes predict survival in patients with chronic lung allograft dysfunction

Pneumologie ◽  
2017 ◽  
Vol 71 (S 01) ◽  
pp. S1-S125
Author(s):  
N Kneidinger ◽  
K Milger ◽  
S Janitza ◽  
F Ceelen ◽  
G Leuschner ◽  
...  
Keyword(s):  
Lung Volumes ◽  
Chronic Lung Allograft Dysfunction ◽  
Allograft Dysfunction

Chronic Lung Allograft Dysfunction is Associated with Acute Rejection and High Levels of Cytomegalovirus Load in Blood (but Not in Lung)

2021 ◽  
Vol 40 (4) ◽  
pp. S336-S337
Author(s):  
D. Piloni ◽  
E. Gabanti ◽  
M. Morosini ◽  
T. Oggionni ◽  
L. Saracino ◽  
...  
Keyword(s):  
Acute Rejection ◽  
Chronic Lung Allograft Dysfunction ◽  
Allograft Dysfunction

scholarly journals Preservation of epoxyeicosatrienoic acid bioavailability prevents renal allograft dysfunction and cardiovascular alterations in kidney transplant recipients

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Thomas Duflot ◽  
Charlotte Laurent ◽  
Anne Soudey ◽  
Xavier Fonrose ◽  
Mouad Hamzaoui ◽  
...  
Keyword(s):  
Endothelial Function ◽  
Kidney Transplant ◽  
Plasma Levels ◽  
Renal Allograft ◽  
Transplant Recipients ◽  
Loss Of Function ◽  
Kidney Transplant Recipients ◽  
Allograft Dysfunction ◽  
Allograft Function ◽  
The Impact

AbstractThis study addressed the hypothesis that epoxyeicosatrienoic acids (EETs) synthesized by CYP450 and catabolized by soluble epoxide hydrolase (sEH) are involved in the maintenance of renal allograft function, either directly or through modulation of cardiovascular function. The impact of single nucleotide polymorphisms (SNPs) in the sEH gene EPHX2 and CYP450 on renal and vascular function, plasma levels of EETs and peripheral blood monuclear cell sEH activity was assessed in 79 kidney transplant recipients explored at least one year after transplantation. Additional experiments in a mouse model mimicking the ischemia–reperfusion (I/R) injury suffered by the transplanted kidney evaluated the cardiovascular and renal effects of the sEH inhibitor t-AUCB administered in drinking water (10 mg/l) during 28 days after surgery. There was a long-term protective effect of the sEH SNP rs6558004, which increased EET plasma levels, on renal allograft function and a deleterious effect of K55R, which increased sEH activity. Surprisingly, the loss-of-function CYP2C9*3 was associated with a better renal function without affecting EET levels. R287Q SNP, which decreased sEH activity, was protective against vascular dysfunction while CYP2C8*3 and 2C9*2 loss-of-function SNP, altered endothelial function by reducing flow-induced EET release. In I/R mice, sEH inhibition reduced kidney lesions, prevented cardiac fibrosis and dysfunction as well as preserved endothelial function. The preservation of EET bioavailability may prevent allograft dysfunction and improve cardiovascular disease in kidney transplant recipients. Inhibition of sEH appears thus as a novel therapeutic option but its impact on other epoxyfatty acids should be carefully evaluated.

scholarly journals Validation of CD4+ CD57+PD1+ T Cells in Bronchoalveolar Lavage as a Biomarker of Lung Allograft Dysfunction

2021 ◽  
Vol 40 (4) ◽  
pp. S61-S62
Author(s):  
S. Moshkelgosha ◽  
L. Levy ◽  
G.W. Wilson ◽  
S. Keshavjee ◽  
T. Martinu ◽  
...  
Keyword(s):  
T Cells ◽  
Bronchoalveolar Lavage ◽  
Allograft Dysfunction
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