Bone Marrow Mesenchymal Stromal Cell Transplantation: A Neurorestorative Therapy for Stroke

2014 ◽  
pp. 47-69
Author(s):  
Jieli Chen ◽  
Poornima Venkat ◽  
Michael Chopp
Keyword(s):  
Bone Marrow ◽  
Cell Transplantation ◽  
Mesenchymal Stromal Cell ◽  
Stromal Cell

In vitro osteogenic potential of collagen/chitosan-based hydrogels-silica particles hybrids in human bone marrow-derived mesenchymal stromal cell cultures

2018 ◽  
Vol 113 ◽  
pp. 692-700 ◽  
Author(s):  
Joanna Filipowska ◽  
Joanna Lewandowska-Łańcucka ◽  
Adriana Gilarska ◽  
Łukasz Niedźwiedzki ◽  
Maria Nowakowska
Keyword(s):  
Bone Marrow ◽  
Cell Cultures ◽  
Mesenchymal Stromal Cell ◽  
Stromal Cell ◽  
Silica Particles ◽  
Human Bone ◽  
Human Bone Marrow ◽  
Osteogenic Potential

Safety of Autologous Bone Marrow Stromal Cell Transplantation in Dogs with Acute Spinal Cord Injury

2012 ◽  
Vol 41 (4) ◽  
pp. 437-442 ◽  
Author(s):  
Hidetaka Nishida ◽  
Masanari Nakayama ◽  
Hiroshi Tanaka ◽  
Masahiko Kitamura ◽  
Shingo Hatoya ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Bone Marrow ◽  
Spinal Cord Injury ◽  
Cell Transplantation ◽  
Stromal Cell ◽  
Bone Marrow Stromal Cell ◽  
Autologous Bone Marrow ◽  
Marrow Stromal Cell ◽  
Cord Injury ◽  
Autologous Bone

scholarly journals Effects of human amnion–derived mesenchymal stromal cell transplantation in rats with radiation proctitis

Cytotherapy ◽  
2015 ◽  
Vol 17 (11) ◽  
pp. 1545-1559 ◽  
Author(s):  
Masayoshi Ono ◽  
Shunsuke Ohnishi ◽  
Minori Honda ◽  
Marin Ishikawa ◽  
Hidetaka Hosono ◽  
...  
Keyword(s):  
Cell Transplantation ◽  
Mesenchymal Stromal Cell ◽  
Stromal Cell ◽  
Radiation Proctitis ◽  
Human Amnion

scholarly journals Combined Autologous Chondrocyte and Bone Marrow Mesenchymal Stromal Cell Implantation in the Knee: An 8-year Follow Up of Two First-In-Man Cases

2019 ◽  
Vol 28 (7) ◽  
pp. 924-931
Author(s):  
Jingsong Wang ◽  
Karina T. Wright ◽  
Jade Perry ◽  
Bernhard Tins ◽  
Timothy Hopkins ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Mesenchymal Stromal Cell ◽  
Stromal Cell ◽  
Knee Function ◽  
Cartilage Defects ◽  
Repair Site ◽  
Cell Implantation ◽  
Autologous Chondrocyte

Autologous chondrocyte implantation (ACI) has been used to treat cartilage defects for >20 years, with promising clinical outcomes. Here, we report two first-in-man cases (patient A and B) treated with combined autologous chondrocyte and bone marrow mesenchymal stromal cell implantation (CACAMI), with 8-year follow up. Two patients with International Cartilage Repair Society (ICRS) grade III–IV cartilage lesions underwent a co-implantation of autologous chondrocytes and bone marrow-derived mesenchymal stromal cells (BM-MSCs) between February 2008 and October 2009. In brief, chondrocytes and BM-MSCs were separately isolated and culture-expanded in a good manufacturing practice laboratory for a period of 2–4 weeks. Cells were then implanted in combination into cartilage defects and patients were clinically evaluated preoperatively and postoperatively, using the self-reported Lysholm knee score and magnetic resonance imaging (MRI). Postoperative Lysholm scores were compared with the Oswestry risk of knee arthroplasty (ORKA) scores. Patient A also had a second-look arthroscopy, at which time a biopsy of the repair site was taken. Both patients demonstrated a significant long-term improvement in knee function, with postoperative Lysholm scores being consistently higher than ORKA predictions. The most recent Lysholm scores, 8 years after surgery were 100/100 (Patient A) and 88/100 (Patient B), where 100 represents a fully functioning knee joint. Bone marrow lesion (BML) volume was shown to decrease on postoperative MRIs in both patients. Cartilage defect area increased in patient A, but declined initially for patient B, slightly increasing again 2 years after treatment. The repair site biopsy taken from patient A at 14 months postoperatively, demonstrated a thin layer of fibrocartilage covering the treated defect site. The use of a combination of cultured autologous chondrocytes and BM-MSCs appears to confer long-term benefit in this two-patient case study. Improvements in knee function perhaps relate to the observed reduction in the size of the BML.

scholarly journals Combination of the multipotent mesenchymal stromal cell transplantation with administration of temozolomide increases survival of rats with experimental glioblastoma

2015 ◽  
Vol 12 (2) ◽  
pp. 2828-2834 ◽  
Author(s):  
IGOR BRYUKHOVETSKIY ◽  
ANDREI BRYUKHOVETSKY ◽  
YURI KHOTIMCHENKO ◽  
POLINA MISCHENKO ◽  
ELENA TOLOK ◽  
...  
Keyword(s):  
Cell Transplantation ◽  
Mesenchymal Stromal Cell ◽  
Stromal Cell ◽  
Multipotent Mesenchymal Stromal Cell
Sign in / Sign up

Export Citation Format

Share Document