Investigation of Antioxidant and Anticancer Potential of Taurine by Means of Multiple Chemical and Biological Assays

Ribosomes are ribonucleoprotein particles necessary for processing the genetic information of mRNA into proteins. Analogy in composition and function of ribosomes from diverse species, established by biochemical and biological assays, implies their structural similarity. Direct evidence obtained by electron microscopy seems to be of increasing relevance in understanding the structure of ribosomes and the mechanism of their role in protein synthesis.The extent of the structural homology between prokaryotic and eukaryotic ribosomes has been studied on ribosomes of Escherichia coli (E.c.) and Artemia salina (A.s.). Despite the established differences in size and in the amount and proportion of ribosomal proteins and RNAs both types of ribosomes show an overall similarity. The monosomes (stained with 0.5% aqueous uranyl acetate and deposited on a fine carbon support) appear in the electron micrographs as round particles with a diameter of approximately 225Å for the 70S E.c. (Fig. 1) and 260Å for the 80S A.s. monosome (Fig. 2).

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Oleacin and oleocanthal: Two olive oil bioactives in multiple chemical forms

Planta Medica ◽

10.1055/s-0032-1321203 ◽

2012 ◽

Vol 78 (11) ◽

Cited By ~ 1

Author(s):

T Michel ◽

A Termentzi ◽

E Gikas ◽

M Halabalaki ◽

AB Smith ◽

...

Keyword(s):

Olive Oil ◽

Chemical Forms ◽

Multiple Chemical

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PET in patients with clear-cut multiple chemical sensitivity (MCS)

Nuklearmedizin ◽

10.1055/s-0038-1625294 ◽

2002 ◽

Vol 41 (06) ◽

pp. 233-239 ◽

Cited By ~ 6

Author(s):

C. Hausteiner ◽

A. Drzezga ◽

P. Bartenstein ◽

M. Schwaiger ◽

H. Förstl ◽

...

Keyword(s):

Single Photon ◽

Photon Emission ◽

Multiple Chemical Sensitivity ◽

Environmental Chemicals ◽

Chemical Sensitivity ◽

Clear Cut ◽

Positron Emission ◽

Symptom Complex ◽

Brain Changes ◽

Multiple Chemical

SummaryAim: Multiple chemical sensitivity (MCS) is a controversially discussed symptom complex. Patients afflicted by MCS react to very low and generally nontoxic concentrations of environmental chemicals. It has been suggested that MCS leads to neurotoxic damage or neuroimmunological alteration in the brain detectable by positron emission tomography (PET) and single photon emission computer tomography (SPECT). These methods are often applied to MCS patients for diagnosis, although they never proved appropriate. Method: We scanned 12 MCS patients with PET, hypothesizing that it would reveal abnormal findings. Results: Mild glucose hypometabolism was present in one patient. In comparison with normal controls, the patient group showed no significant functional brain changes. Conclusion: This first systematic PET study in MCS patients revealed no hint of neurotoxic or neuroimmuno-logical brain changes of functional significance.

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Semi-quantitative estimation of human chorionic gonadotrophin in urine by immunological and biological assays during pregnancy

Reproduction ◽

10.1530/jrf.0.0270308 ◽

1971 ◽

Vol 27 (2) ◽

pp. 308-309

Author(s):

S. Shahani ◽

P. Dandekar

Keyword(s):

Quantitative Estimation ◽

Chorionic Gonadotrophin ◽

Human Chorionic Gonadotrophin ◽

Biological Assays

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Multiple Chemical Sensitivity: Potential Role for Neural Sensitization

Critical Reviews in Neurobiology ◽

10.1615/critrevneurobiol.v13.i3.30 ◽

1999 ◽

Vol 13 (3) ◽

pp. 283-316 ◽

Cited By ~ 51

Author(s):

Barbara A. Sorg

Keyword(s):

Potential Role ◽

Multiple Chemical Sensitivity ◽

Chemical Sensitivity ◽

Neural Sensitization ◽

Multiple Chemical

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HPLC-DAD–MSnanalysis of multiple chemical constituents in a Chinese herbal preparation Shuang-Huang-Lian injection

Human Health and Medical Engineering ◽

10.2495/hhme130831 ◽

2014 ◽

Author(s):

Jiayu Zhang ◽

Qian Zhang ◽

Ying Liu ◽

Wei Cai ◽

Fang Wang ◽

...

Keyword(s):

Chemical Constituents ◽

Herbal Preparation ◽

Chinese Herbal ◽

Multiple Chemical

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Anacyclamide D8P, a prenylated cyanobactin from a Sphaerospermopsis sp. cyanobacterium

10.26434/chemrxiv.5346739.v1 ◽

2017 ◽

Cited By ~ 1

Author(s):

Joana Martins ◽

Niina Leikoski ◽

Matti Wahlsten ◽

Joana Azevedo ◽

Jorge Antunes ◽

...

Keyword(s):

Gene Cluster ◽

Cyclic Peptides ◽

Biosynthetic Gene Cluster ◽

The Novel ◽

Tyrosine Residue ◽

Biosynthetic Gene ◽

Post Translational Modification ◽

Biological Assays ◽

Mass Spectrometric Data ◽

Spectrometric Data

Cyanobactins are a family of linear and cyclic peptides produced through the post-translational modification of short precursor peptides. Anacyclamides are macrocyclic cyanobactins with a highly diverse sequence that are common in the genus Anabaena. A mass spectrometry-based screening of potential cyanobactin producers led to the discovery of a new prenylated member of this family of compounds, anacyclamide D8P (1), from Sphaerospermopsis sp. LEGE 00249. The anacyclamide biosynthetic gene cluster (acy) encoding the novel macrocyclic prenylated cyanobactin, was sequenced. Heterologous expression of the acy gene cluster in Escherichia coli established the connection between genomic and mass spectrometric data. Unambiguous establishment of the type and site of prenylation required the full structural elucidation of 1 using Nuclear Magnetic Resonance (NMR), which demonstrated that a forward prenylation occurred on the tyrosine residue. Compound 1 was tested in pharmacologically or ecologically relevant biological assays and revealed moderate antimicrobial activity towards the fouling bacterium Halomonas aquamarina CECT 5000.

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