Hyperbaric Oxygen Therapy Improves Glucose Homeostasis in Type 2 Diabetes Patients: A Likely Involvement of the Carotid Bodies

2015 ◽  
pp. 221-225 ◽  
Author(s):  
P. Vera-Cruz ◽  
F. Guerreiro ◽  
M. J. Ribeiro ◽  
M. P. Guarino ◽  
S. V. Conde
Keyword(s):  
Type 2 Diabetes ◽  
Hyperbaric Oxygen ◽  
Glucose Homeostasis ◽  
Hyperbaric Oxygen Therapy ◽  
Oxygen Therapy ◽  
Carotid Bodies ◽  
Diabetes Patients

scholarly journals Hyperbaric Oxygen Therapy in Ischaemic Foot Ulcers in Type 2 Diabetes: A Clinical Trial

2018 ◽  
Vol 12 (1) ◽  
pp. 80-85 ◽  
Author(s):  
Sarah Perren ◽  
Alfred Gatt ◽  
Nikolaos Papanas ◽  
Cynthia Formosa
Keyword(s):  
Type 2 Diabetes ◽  
Hyperbaric Oxygen ◽  
Hyperbaric Oxygen Therapy ◽  
Oxygen Therapy ◽  
Foot Ulcer ◽  
Treatment Modalities ◽  
Foot Ulcers ◽  
Ulcer Area ◽  
Group A

Background and Aims: Several treatment modalities and protocols for ischaemic foot ulcers are available. However, little consensus exists on optimal treatment. The aim of this study was to compare Standard Wound Care (SWC) alone vs. SWC with adjunct hyperbaric oxygen therapy (HBOT) in the treatment of ischaemic Diabetic Foot Ulcers (DFUs). Patients and Methods: Twenty-six patients with Type 2 Diabetes Mellitus (T2DM) presenting with a newly diagnosed ischaemic foot ulcer were included. These were divided into group A (SWC with adjunct HBOT) and group B (SWC only). Participants were followed every week for 4 weeks and their ulcers were measured for their surface area and depth to assess any change in wound size. Results: Both treatment arms succeeded in reducing ulcer area and depth (p<0.001). However, ulcer area (p<0.001) and depth (p<0.001) exhibited superior improvement in group A. Conclusion : Adjunctive HBOT appears to improve wound healing in ischaemic DFUs and merits further study.

scholarly journals Evaluation of the healing progress of phlegmon related to type 2 diabetes treated with the local hyperbaric oxygen therapy

2018 ◽  
Vol 24 (3) ◽  
pp. 93-97 ◽  
Author(s):  
Jarosław Pasek ◽  
Grzegorz Cieślar ◽  
Aleksander Sieroń
Keyword(s):  
Type 2 Diabetes ◽  
Hyperbaric Oxygen ◽  
Hyperbaric Oxygen Therapy ◽  
Oxygen Therapy

scholarly journals Treatment of a Chronic Vulvar Wound by Hyperbaric Oxygen Therapy (HBOT)

2022 ◽  
Vol 2022 ◽  
pp. 1-3
Author(s):  
D. Ricard-Gauthier ◽  
M.-A. Panchard ◽  
D. E. Huber
Keyword(s):  
Type 2 Diabetes ◽  
Obese Patient ◽  
Hyperbaric Oxygen ◽  
Hyperbaric Oxygen Therapy ◽  
Oxygen Therapy ◽  
Wound Care ◽  
Surgical Drainage ◽  
Skin Atrophy ◽  
Labia Majora

We hereby report the case of a 66-year-old obese patient (BMI 30) with type 2 diabetes, who presented a chronic vulvar lesion on the left labia majora following surgical drainage of an abscess. After multiple unsuccessful treatments by antibiotics and local wound care, we proposed a trial of hyperbaric oxygen therapy (HBOT). The patient fully recovered after 54 sessions at 2.5 ATA, 95 minutes each. HBOT has been studied for perineal lesion such as skin atrophy or necrosis caused by irradiation but not for vulvar nonhealing chronic lesions in the case of impaired vascularization caused by diabetes. This case is, to our knowledge, one of the first publications about the healing boost of HBOT in chronic vulvar wounds due to vascular impairment.

Hyperbaric oxygen therapy increases insulin sensitivity in overweight men with and without type 2 diabetes

2013 ◽  
Vol 7 ◽  
pp. e5-e6
Author(s):  
Leonie Heilbronn ◽  
David Wilkinson ◽  
Mirjam Nolting ◽  
Mohd Mahadi ◽  
Ian Chapman
Keyword(s):  
Type 2 Diabetes ◽  
Insulin Sensitivity ◽  
Hyperbaric Oxygen ◽  
Hyperbaric Oxygen Therapy ◽  
Oxygen Therapy

scholarly journals Exploring the Mediators that Promote Carotid Body Dysfunction in Type 2 Diabetes and Obesity Related Syndromes

2020 ◽  
Vol 21 (15) ◽  
pp. 5545 ◽  
Author(s):  
Joana F. Sacramento ◽  
Kryspin Andrzejewski ◽  
Bernardete F. Melo ◽  
Maria J. Ribeiro ◽  
Ana Obeso ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Glucose Homeostasis ◽  
Metabolic Diseases ◽  
Sympathetic Nerves ◽  
Beneficial Effects ◽  
Carotid Bodies ◽  
Major Factors ◽  
Diabetes And Obesity ◽  
Pro Inflammatory Cytokines

Carotid bodies (CBs) are peripheral chemoreceptors that sense changes in blood O2, CO2, and pH levels. Apart from ventilatory control, these organs are deeply involved in the homeostatic regulation of carbohydrates and lipid metabolism and inflammation. It has been described that CB dysfunction is involved in the genesis of metabolic diseases and that CB overactivation is present in animal models of metabolic disease and in prediabetes patients. Additionally, resection of the CB-sensitive nerve, the carotid sinus nerve (CSN), or CB ablation in animals prevents and reverses diet-induced insulin resistance and glucose intolerance as well as sympathoadrenal overactivity, meaning that the beneficial effects of decreasing CB activity on glucose homeostasis are modulated by target-related efferent sympathetic nerves, through a reflex initiated in the CBs. In agreement with our pre-clinical data, hyperbaric oxygen therapy, which reduces CB activity, improves glucose homeostasis in type 2 diabetes patients. Insulin, leptin, and pro-inflammatory cytokines activate the CB. In this manuscript, we review in a concise manner the putative pathways linking CB chemoreceptor deregulation with the pathogenesis of metabolic diseases and discuss and present new data that highlight the roles of hyperinsulinemia, hyperleptinemia, and chronic inflammation as major factors contributing to CB dysfunction in metabolic disorders.

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