Choosing the Right Patient for Lung Transplantation: Assessment of Histocompatibility and Sensitization Status

Author(s):  
Qingyong Xu ◽  
Massimo Mangiola ◽  
Adriana Zeevi

2001 ◽  
Vol 72 (3) ◽  
pp. 933-935 ◽  
Author(s):  
Jean-Paul Couetil ◽  
Pantelis G Argyriadis ◽  
Michael J Tolan ◽  
Antoine Achkar ◽  
Alain F Carpentier


2011 ◽  
Vol 25 (1) ◽  
pp. E38-E45 ◽  
Author(s):  
Dirk Habedank ◽  
Ralf Ewert ◽  
Manfred Hummel ◽  
Michael Dandel ◽  
Friedrich Habedank ◽  
...  


1995 ◽  
Vol 5 (3) ◽  
pp. 278-281 ◽  
Author(s):  
Gül Sagin Saylam ◽  
Jane Somerville

SummaryWe present a patient with primary pulmonary hypertension who had unusually high pulmonary arterial pressure prior to double-lung transplantation. Obstruction of the right ventricular outflow tract developed after transplantation and progressed over the subsequent two years.



2012 ◽  
Vol 94 (10S) ◽  
pp. 211
Author(s):  
I. Tudorache ◽  
C. Kuehn ◽  
W. Sommer ◽  
M. Avsar ◽  
O. Wiesner ◽  
...  


2021 ◽  
Vol 9 (1) ◽  
Author(s):  
Anna Elisabeth Frick ◽  
Michaela Orlitová ◽  
Arno Vanstapel ◽  
Sofie Ordies ◽  
Sandra Claes ◽  
...  

Abstract Background Primary graft dysfunction (PGD) remains a major obstacle after lung transplantation. Ischemia–reperfusion injury is a known contributor to the development of PGD following lung transplantation. We developed a novel approach to assess the impact of increased pulmonary blood flow in a large porcine single-left lung transplantation model. Materials Twelve porcine left lung transplants were divided in two groups (n = 6, in low- (LF) and high-flow (HF) group). Donor lungs were stored for 24 h on ice, followed by left lung transplantation. In the HF group, recipient animals were observed for 6 h after reperfusion with partially clamping right pulmonary artery to achieve a higher flow (target flow 40–60% of total cardiac output) to the transplanted lung compared to the LF group, where the right pulmonary artery was not clamped. Results Survival at 6 h was 100% in both groups. Histological, functional and biological assessment did not significantly differ between both groups during the first 6 h of reperfusion. injury was also present in the right native lung and showed signs compatible with the pathophysiological hallmarks of ischemia–reperfusion injury. Conclusions Partial clamping native pulmonary artery in large animal lung transplantation setting to study the impact of low versus high pulmonary flow on the development of ischemia reperfusion is feasible. In our study, differential blood flow had no effect on IRI. However, our findings might impact future studies with extracorporeal devices and represent a specific intra-operative problem during bilateral sequential single-lung transplantation.



Author(s):  
Mitul B. Modi ◽  
Ata S. Moshiri ◽  
Toru Shoji ◽  
Martin C. Mihm ◽  
Xiaowei Xu ◽  
...  

Abstract Background Eccrine porocarcinoma is a rare malignancy accounting for 0.005 to 0.01% of all cutaneous tumors. However, its etiology is not well established. Herein we are reporting the occurrence of metastatic porocarcinoma of the back in a patient with a history of multiple cutaneous malignancies and chronic immunosuppression. Case presentation A 79-year-old male with a history of long-term immunosuppressive therapy for left lung transplantation and multiple cutaneous malignancies including melanoma, presented with an enlargening plaque on the right upper back. Biopsy demonstrated an infiltrative epithelial tumor with aggressive histology and ductal formation. Immunohistochemical stains for p63, CK-5/6, and CEA were diffusely positive, while CK-7 and CK-20 were negative. A diagnosis of eccrine porocarcinoma was made. He underwent complete wide excision with negative margins of the right upper back in January 2018. In November 2018, he was found to have a right posterior shoulder mass, positive right axillary lymph nodes, superficial right upper back soft tissue masses and lymphangitic carcinomatosis involving the left lung. He was transitioned to comfort care and subsequently passed from metastatic disease in December 2018. Conclusion The occurrence of eccrine porocarcinoma in a patient on long term immunosuppressive therapy for lung transplantation suggests a possible role for chronic immunosuppression in the induction of a subset of eccrine porocarcinomas, as in other cutaneous malignancies.



2010 ◽  
Vol 89 (6) ◽  
pp. 2000-2001 ◽  
Author(s):  
Spencer J. Melby ◽  
Shane J. Larue ◽  
John M. Lasala ◽  
Nirvik Pal ◽  
Anand Lakshminarasimhachar ◽  
...  


2021 ◽  
pp. 317-329
Author(s):  
Robert P. Frantz


2016 ◽  
Vol 73 (4) ◽  
Author(s):  
S. Aliberti ◽  
M.C. Andrisani ◽  
P. Tarsia ◽  
R. Trevisan ◽  
R. Cosentini ◽  
...  

Patients who undergo lung transplantation are prone to develop lower respiratory tract infections, leading to severe acute respiratory failure (ARF). Endotracheal intubation may not be indicated in these patients in light of a higher rate of mortality due to infections. The application of non-invasive ventilation could play a role in bridging these patients through the episode of ARF waiting for medical treatment to have effect. We report the evidence of morphological and physiological effects of the application of non-invasive continuous positive airway pressure during ARF sustained by pneumonia in a patient who underwent left lung transplantation because of idiopathic pulmonary fibrosis (IPF). We studied the effects of the application of positive end-expiratory pressure on both the right native lung affected by IPF and the transplanted lung affected by pneumonia.



1994 ◽  
Vol 73 (7) ◽  
pp. 494-500 ◽  
Author(s):  
Mordechai R. Kramer ◽  
Hannah A. Valantine ◽  
Sara E. Marshall ◽  
Vaughn A. Starnes ◽  
James Theodore


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