Long-Term Follow-up in Medullary Thyroid Carcinoma

2015 ◽  
pp. 207-225 ◽  
Author(s):  
Friedhelm Raue ◽  
Karin Frank-Raue
Keyword(s):  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Medullary Thyroid ◽  
Long Term Follow Up

Medullary Thyroid Carcinoma: Clinical Features and Long-Term Follow-up of Seventy-Eight Patients Treated Between 1969 and 1986

Thyroid ◽  
1998 ◽  
Vol 8 (6) ◽  
pp. 517-523 ◽  
Author(s):  
M.E. GIRELLI ◽  
D. NACAMULLI ◽  
M.R. PELIZZO ◽  
D. DE VIDO ◽  
C. MIAN ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Clinical Features ◽  
Medullary Thyroid ◽  
Long Term Follow Up

Medullary Thyroid Carcinoma: Clinicopathologic Features and Long-Term Follow-Up of 65 Patients Treated During 1946 Through 1970

1992 ◽  
Vol 67 (10) ◽  
pp. 934-940 ◽  
Author(s):  
HOSSEIN GHARIB ◽  
WILLIAM M. McCONAHEY ◽  
ROBERT D. TIEGS ◽  
ERIK J. BERGSTRALH ◽  
JOHN R. GOELLNER ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Clinicopathologic Features ◽  
Medullary Thyroid ◽  
Long Term Follow Up

Long-Term Clinical and Biochemical Follow-up in Medullary Thyroid Carcinoma

2007 ◽  
Vol 246 (5) ◽  
pp. 815-821 ◽  
Author(s):  
Kenko Cupisti ◽  
Achim Wolf ◽  
Andreas Raffel ◽  
Matthias Schott ◽  
Daniel Miersch ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Medullary Thyroid

scholarly journals Clinico-pathologic and dynamic prognostic factors in sporadic and familial medullary thyroid carcinoma: an Israeli multi-center study

2019 ◽  
Vol 181 (1) ◽  
pp. 13-21 ◽  
Author(s):  
Orit Twito ◽  
Simona Grozinsky-Glasberg ◽  
Sigal Levy ◽  
Gideon Bachar ◽  
David J Gross ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Initial Treatment ◽  
Treatment Decision ◽  
Distant Metastases ◽  
Medullary Thyroid ◽  
Measure Of Association ◽  
Disease Persistence

ObjectiveMultiple clinical, pathological and biochemical variables, including the response to initial treatment, are associated with medullary thyroid carcinoma (MTC) prognosis. Studies that include separate analyses of familial and sporadic MTC patients followed for long period are scarce. This study evaluated the association between baseline clinico-pathologic variables and response to initial treatment and short- and long-term disease outcomes in sporadic and familial MTC.MethodsPatients treated for MTC at four tertiary medical centers were retrospectively analyzed. Clinical and pathological data were collected. The outcomes measured included disease persistence 1 year after diagnosis, disease persistence at last follow-up, disease-related mortality (DRM) and all-cause mortality.ResultsThe study enrolled 193 patients (mean age: 48.9 ± 18.7, 44.7% males), of whom 18.1% were familial cases. The mean follow-up period was 10.1 ± 9.4 years (8.5 ± 8.1 in sporadic and 16.9 ± 11.6 in familial MTC). Disease persistence 1-year after diagnosis and at last follow-up was detected in 56.1 and 60.4% patients, respectively. All-cause and DRM were 28.5 and 12.6%, respectively. Extra-thyroidal extension (ETE) and distant metastases (DM) were associated with disease persistence at last follow-up. ETE and DM were also significantly associated with DRM. Complete remission 1 year after diagnosis had high correlation with no evidence of disease at last follow-up (Cramer’s V measure of association 0.884,P < 0.001) and with 100% disease-specific survival (Cramer’s V measure of association 0.38,P < 0.001).ConclusionsApart from clinico-pathologic parameters, close correlation was found between 1-year status and long-term prognosis. These results underscore the importance of combining classical and dynamic factors for both sporadic and familial MTC prognostication and treatment decision making.

Abstract #87: Long-Term Survival in a Patient with MEN2B and Metastatic Medullary Thyroid Carcinoma

2004 ◽  
Vol 10 ◽  
pp. 29-30
Author(s):  
Claudia Panzer ◽  
Robert Beazley ◽  
Stuart Chipkin ◽  
Susanne Ebner
Keyword(s):  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Term Survival ◽  
Long Term Survival ◽  
Medullary Thyroid

Long-term follow-up of differentiated thyroid carcinoma in children and adolescents

2020 ◽  
Vol 33 (11) ◽  
pp. 1431-1441
Author(s):  
Montserrat Negre Busó ◽  
Amparo García Burillo ◽  
Marc Simó Perdigó ◽  
Pere Galofré Mora ◽  
Maria Boronat de Ferrater ◽  
...  
Keyword(s):  
Complete Remission ◽  
Thyroid Carcinoma ◽  
Children And Adolescents ◽  
Differentiated Thyroid Carcinoma ◽  
Radioiodine Treatment ◽  
Persistent Disease ◽  
Stage 4 ◽  
Long Term Follow Up

AbstractObjectivesThe aims were to analyze the clinical features, response to treatment, prognostic factors and long-term follow-up of children and adolescents with differentiated thyroid carcinoma (DTC).MethodsEighty patients with DTC were studied retrospectively. All underwent total or near-total thyroidectomy, and in 75 cases, ablative iodine therapy was recommended. Patients were assessed periodically by tests for serum thyroglobulin levels and whole-body iodine scans. Age, gender, initial clinical presentation, histology, tumor stage, postoperative complications, radioiodine treatment protocol, treatment response, thyroglobulin (Tg), recurrence and long-term disease progression were evaluated.ResultsSeventy patients completed >2 years of follow-up (23 males, 47 females; median age: 14 years; range: 3–18 years). Sixty-two patients showed papillary DTC and eight, follicular DTC. Sixty-five percent presented nodal metastasis and 16%, pulmonary metastasis at diagnosis. Six months after first radioiodine treatment, 36.2% of patients were free of disease. Seven recurrences were documented. At the end of follow-up, overall survival was 100%, and 87.2% of patients were in complete remission. Nine patients had persistent disease. We found a significant association between stage 4 and persistent disease. Hundred percent of patients with negative Tg values at 6 months posttreatment were documented free of disease at the end of the follow-up. The analysis of disease-free survival based on radioiodine treatment protocols used showed no statistically significant differences.ConclusionsDTC in children and adolescents is frequently associated with presence of advanced disease at diagnosis. Despite this, complete remission was documented after treatment in most cases, with a good prognosis in the long-term follow-up. Negative posttreatment thyroglobulin and stage 4 at diagnosis were significant prognostic variables.

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