Recombinant Allergens in Specific Immunotherapy

2017 ◽  
pp. 473-486 ◽  
Author(s):  
A. Nandy ◽  
P. S. Creticos ◽  
D. Häfner
Keyword(s):  
Specific Immunotherapy ◽  
Recombinant Allergens

Recombinant allergens for specific immunotherapy

2011 ◽  
Vol 127 (4) ◽  
pp. 865-872 ◽  
Author(s):  
Oliver Cromwell ◽  
Dietrich Häfner ◽  
Andreas Nandy
Keyword(s):  
Specific Immunotherapy ◽  
Recombinant Allergens

Recombinant allergens for specific immunotherapy

Allergy ◽  
1999 ◽  
Vol 54 (s56) ◽  
pp. 43-44 ◽  
Author(s):  
R. Valenta ◽  
S. Vrtala
Keyword(s):  
Specific Immunotherapy ◽  
Recombinant Allergens

Recombinant allergens in specific immunotherapy

2015 ◽  
Vol 24 (5) ◽  
pp. 143-151 ◽  
Author(s):  
Andreas Nandy ◽  
Dietrich Häfner ◽  
Steen Klysner
Keyword(s):  
Specific Immunotherapy ◽  
Recombinant Allergens

Allergy testing: the role of recombinant allergens

2006 ◽  
Vol 44 (2) ◽  
Author(s):  
Nadine Mothes ◽  
Rudolf Valenta ◽  
Susanne Spitzauer
Keyword(s):  
Specific Immunotherapy ◽  
Simultaneous Detection ◽  
In Vitro Tests ◽  
Recombinant Allergen ◽  
Recombinant Allergens ◽  
Type I ◽  
Type I Allergy ◽  
Specific Igg ◽  
Allergen Extracts

AbstractCurrently, diagnosis of type I allergy is performed using crude allergen extracts, which allow the identification of the allergen-containing source responsible for type I allergic symptoms (e.g., allergic rhino-conjunctivitis, asthma) but not the disease-eliciting molecules. With the introduction of recombinant allergens produced by molecular biology techniques, a large panel of allergenic molecules has become available. The application of these recombinant allergens for in vitro tests has led to new forms of component-resolved diagnosis (CRD) and allows the establishment of a patient's individual reactivity profile. The increasing number of recombinant allergens characterized during the last decade has allowed the development of chip-based allergy tests for simultaneous detection of up to 5000 different allergens and epitopes. The introduction of these recombinant allergen-based tests into clinical practice improves the selection of patients for traditional specific immunotherapy and allows monitoring of the immunological efficacy of specific immunotherapy by measuring allergen-specific IgG antibodies. Besides their diagnostic application, recombinant allergens and hypoallergenic derivatives thereof have also been used as vaccines in clinical trials, and recent results have shown their usefulness for the treatment of type I allergy.

scholarly journals Allergen Peptides, Recombinant Allergens and Hypoallergens for Allergen-Specific Immunotherapy

2014 ◽  
Vol 1 (1) ◽  
pp. 91-106 ◽  
Author(s):  
Katharina Marth ◽  
Margarete Focke-Tejkl ◽  
Christian Lupinek ◽  
Rudolf Valenta ◽  
Verena Niederberger
Keyword(s):  
Specific Immunotherapy ◽  
Recombinant Allergens ◽  
Allergen Specific Immunotherapy
Sign in / Sign up

Export Citation Format

Share Document