Structural Details of the Ryanodine Receptor Calcium Release Channel and Its Gating Mechanism

2017 ◽  
pp. 179-204
Author(s):  
Katrien Willegems ◽  
Rouslan G. Efremov
Keyword(s):  
Ryanodine Receptor ◽  
Calcium Release ◽  
Calcium Release Channel ◽  
Release Channel ◽  
Gating Mechanism ◽  
Structural Details

scholarly journals Unravelling calcium-release channel gating: clues from a hot disease

2004 ◽  
Vol 380 (1) ◽  
pp. e1-e3 ◽  
Author(s):  
Tommie V. McCARTHY ◽  
John J. MACKRILL
Keyword(s):  
Calcium Release ◽  
Distinct Point ◽  
Ryanodine Receptors ◽  
Point Mutations ◽  
Calcium Release Channel ◽  
Release Channel ◽  
Present Evidence ◽  
Gating Mechanism ◽  
Biochemical Journal ◽  
Interdomain Interactions

Ryanodine receptors (RyRs) are a family of intracellular channels that mediate Ca2+ release from the endoplasmic and sarcoplasmic reticulum. More than 50 distinct point mutations in one member of this family, RyR1, cause malignant hyperthermia, a potentially lethal pharmacogenetic disorder of skeletal muscle. These mutations are not randomly distributed throughout the primary structure of RyR1, but are grouped in three discrete clusters. In this issue of the Biochemical Journal, Kobayashi et al. present evidence that interdomain interactions between two of these mutation-enriched regions play a key role in the gating mechanism of RyR1.

scholarly journals Protein Kinase A Phosphorylation of the Cardiac Calcium Release Channel (Ryanodine Receptor) in Normal and Failing Hearts

2002 ◽  
Vol 278 (1) ◽  
pp. 444-453 ◽  
Author(s):  
Steven Reiken ◽  
Marta Gaburjakova ◽  
Silvia Guatimosim ◽  
Ana M. Gomez ◽  
Jeanine D'Armiento ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Protein Kinase A ◽  
Ryanodine Receptor ◽  
Calcium Release ◽  
Calcium Release Channel ◽  
Release Channel ◽  
Kinase A

Inactivation of the cardiac ryanodine receptor calcium release channel by nitric oxide

Cell Calcium ◽  
1997 ◽  
Vol 22 (6) ◽  
pp. 447-453 ◽  
Author(s):  
Alexandra Zahradníková ◽  
Igor Minarovic ◽  
Richard C. Venema ◽  
LászlóG. Meszaros
Keyword(s):  
Nitric Oxide ◽  
Ryanodine Receptor ◽  
Calcium Release ◽  
Calcium Release Channel ◽  
Release Channel ◽  
Cardiac Ryanodine Receptor

Functional expression of cDNA encoding the calcium release channel (ryanodine receptor) of rabbit skeletal muscle sarcoplasmic reticulum in COS-1 cells

Biochemistry ◽  
1993 ◽  
Vol 32 (14) ◽  
pp. 3743-3753 ◽  
Author(s):  
S. R. Wayne Chen ◽  
Donna M. Vaughan ◽  
Judith A. Airey ◽  
Roberto Coronado ◽  
David H. MacLennan
Keyword(s):  
Skeletal Muscle ◽  
Sarcoplasmic Reticulum ◽  
Ryanodine Receptor ◽  
Calcium Release ◽  
Functional Expression ◽  
Rabbit Skeletal Muscle ◽  
Calcium Release Channel ◽  
Release Channel

scholarly journals cDNA cloning reveals a tissue specific expression of alternatively spliced transcripts of the ryanodine receptor type 3 (RyR3) calcium release channel

FEBS Letters ◽  
1996 ◽  
Vol 394 (1) ◽  
pp. 76-82 ◽  
Author(s):  
Giovanna Marziali ◽  
Daniela Rossi ◽  
Giuseppe Giannini ◽  
Alexandra Charlesworth ◽  
Vincenzo Sorrentino
Keyword(s):  
Ryanodine Receptor ◽  
Cdna Cloning ◽  
Calcium Release ◽  
Receptor Type ◽  
Calcium Release Channel ◽  
Specific Expression ◽  
Release Channel ◽  
Tissue Specific Expression ◽  
Alternatively Spliced ◽  
Type 3

Membrane Topology and Membrane Retention of the Ryanodine Receptor Calcium Release Channel

2004 ◽  
Vol 40 (2) ◽  
pp. 207-224 ◽  
Author(s):  
Jianjie Ma ◽  
Salim M. Hayek ◽  
Manjunatha B. Bhat
Keyword(s):  
Ryanodine Receptor ◽  
Calcium Release ◽  
Membrane Topology ◽  
Calcium Release Channel ◽  
Release Channel

scholarly journals Ryanodine receptor/calcium release channel PKA phosphorylation: A critical mediator of heart failure progression

2006 ◽  
Vol 103 (3) ◽  
pp. 511-518 ◽  
Author(s):  
X. H. T. Wehrens ◽  
S. E. Lehnart ◽  
S. Reiken ◽  
J. A. Vest ◽  
A. Wronska ◽  
...  
Keyword(s):  
Heart Failure ◽  
Ryanodine Receptor ◽  
Calcium Release ◽  
Calcium Release Channel ◽  
Release Channel ◽  
Heart Failure Progression
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