(De)constructing the Ryanodine Receptor: Modeling Ion Permeation and Selectivity of the Calcium Release Channel

The Journal of Physical Chemistry B ◽

10.1021/jp052471j ◽

2005 ◽

Vol 109 (32) ◽

pp. 15598-15610 ◽

Author(s):

Dirk Gillespie ◽

Le Xu ◽

Ying Wang ◽

Gerhard Meissner

Keyword(s):

Ryanodine Receptor ◽

Calcium Release ◽

Receptor Modeling ◽

Ion Permeation ◽

Calcium Release Channel ◽

Release Channel

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Calcium Ion Permeation through the Calcium Release Channel (Ryanodine Receptor) of Cardiac Muscle

The Journal of Physical Chemistry B ◽

10.1021/jp0354191 ◽

2003 ◽

Vol 107 (34) ◽

pp. 9139-9145 ◽

Author(s):

Duan P. Chen ◽

Le Xu ◽

Bob Eisenberg ◽

Gerhard Meissner

Keyword(s):

Cardiac Muscle ◽

Ryanodine Receptor ◽

Calcium Ion ◽

Calcium Release ◽

Ion Permeation ◽

Calcium Release Channel ◽

Release Channel

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Protein Kinase A Phosphorylation of the Cardiac Calcium Release Channel (Ryanodine Receptor) in Normal and Failing Hearts

Journal of Biological Chemistry ◽

10.1074/jbc.m207028200 ◽

2002 ◽

Vol 278 (1) ◽

pp. 444-453 ◽

Author(s):

Steven Reiken ◽

Marta Gaburjakova ◽

Silvia Guatimosim ◽

Ana M. Gomez ◽

Jeanine D'Armiento ◽

...

Keyword(s):

Protein Kinase ◽

Protein Kinase A ◽

Ryanodine Receptor ◽

Calcium Release ◽

Calcium Release Channel ◽

Release Channel ◽

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Inactivation of the cardiac ryanodine receptor calcium release channel by nitric oxide

Cell Calcium ◽

10.1016/s0143-4160(97)90072-5 ◽

1997 ◽

Vol 22 (6) ◽

pp. 447-453 ◽

Author(s):

Alexandra Zahradníková ◽

Igor Minarovic ◽

Richard C. Venema ◽

LászlóG. Meszaros

Keyword(s):

Nitric Oxide ◽

Ryanodine Receptor ◽

Calcium Release ◽

Calcium Release Channel ◽

Release Channel ◽

Cardiac Ryanodine Receptor

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Functional expression of cDNA encoding the calcium release channel (ryanodine receptor) of rabbit skeletal muscle sarcoplasmic reticulum in COS-1 cells

Biochemistry ◽

10.1021/bi00065a029 ◽

1993 ◽

Vol 32 (14) ◽

pp. 3743-3753 ◽

Author(s):

S. R. Wayne Chen ◽

Donna M. Vaughan ◽

Judith A. Airey ◽

Roberto Coronado ◽

David H. MacLennan

Keyword(s):

Skeletal Muscle ◽

Sarcoplasmic Reticulum ◽

Ryanodine Receptor ◽

Calcium Release ◽

Functional Expression ◽

Rabbit Skeletal Muscle ◽

Calcium Release Channel ◽

Release Channel

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Affinity Purification of the Ryanodine Receptor/Calcium Release Channel from Fast Twitch Skeletal Muscle Based on Its Tight Association with FKBP12

Biochemical and Biophysical Research Communications ◽

10.1006/bbrc.1995.2283 ◽

1995 ◽

Vol 214 (1) ◽

pp. 263-270 ◽

Author(s):

H.B. Xin ◽

A.P. Timerman ◽

H. Onoue ◽

G.J. Wiederrecht ◽

S. Fleischer

Keyword(s):

Skeletal Muscle ◽

Ryanodine Receptor ◽

Calcium Release ◽

Affinity Purification ◽

Calcium Release Channel ◽

Release Channel ◽

Tight Association ◽

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cDNA cloning reveals a tissue specific expression of alternatively spliced transcripts of the ryanodine receptor type 3 (RyR3) calcium release channel

FEBS Letters ◽

10.1016/0014-5793(96)00944-1 ◽

1996 ◽

Vol 394 (1) ◽

pp. 76-82 ◽

Author(s):

Giovanna Marziali ◽

Daniela Rossi ◽

Giuseppe Giannini ◽

Alexandra Charlesworth ◽

Vincenzo Sorrentino

Keyword(s):

Ryanodine Receptor ◽

Cdna Cloning ◽

Calcium Release ◽

Receptor Type ◽

Calcium Release Channel ◽

Specific Expression ◽

Release Channel ◽

Tissue Specific Expression ◽

Alternatively Spliced ◽

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Phosphorylation of serine 2843 in ryanodine receptor-calcium release channel of skeletal muscle by cAMP-, cGMP- and CaM-dependent protein kinase

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research ◽

10.1016/0167-4889(93)90023-i ◽

1993 ◽

Vol 1175 (2) ◽

pp. 193-206 ◽

Author(s):

Josef Suko ◽

Ingrid Maurer-Fogy ◽

Brigitte Plank ◽

Oswald Bertel ◽

Wolfgang Wyskovsky ◽

...

Keyword(s):

Skeletal Muscle ◽

Protein Kinase ◽

Ryanodine Receptor ◽

Calcium Release ◽

Calcium Release Channel ◽

Dependent Protein Kinase ◽

Release Channel ◽

Dependent Protein

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Membrane Topology and Membrane Retention of the Ryanodine Receptor Calcium Release Channel

Cell Biochemistry and Biophysics ◽

10.1385/cbb:40:2:207 ◽

2004 ◽

Vol 40 (2) ◽

pp. 207-224 ◽

Author(s):

Jianjie Ma ◽

Salim M. Hayek ◽

Manjunatha B. Bhat

Keyword(s):

Ryanodine Receptor ◽

Calcium Release ◽

Membrane Topology ◽

Calcium Release Channel ◽

Release Channel

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Ryanodine receptor/calcium release channel PKA phosphorylation: A critical mediator of heart failure progression

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.0510113103 ◽

2006 ◽

Vol 103 (3) ◽

pp. 511-518 ◽

Author(s):

X. H. T. Wehrens ◽

S. E. Lehnart ◽

S. Reiken ◽

J. A. Vest ◽

A. Wronska ◽

...

Keyword(s):

Heart Failure ◽

Ryanodine Receptor ◽

Calcium Release ◽

Calcium Release Channel ◽

Release Channel ◽

Heart Failure Progression

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Redox regulation of the ryanodine receptor/calcium release channel

Biochemical Society Transactions ◽

10.1042/bst0340919 ◽

2006 ◽

Vol 34 (5) ◽

pp. 919-921 ◽

Author(s):

S. Zissimopoulos ◽

F.A. Lai

Keyword(s):

Ryanodine Receptor ◽

Protein Interactions ◽

Redox Regulation ◽

Opposite Effect ◽

Calcium Release ◽

Calcium Release Channel ◽

Release Channel ◽

Reducing Conditions ◽

Channel Opening ◽

Redox Sensitivity

The RyR (ryanodine receptor)/calcium release channel contains a number of highly reactive thiol groups that endow it with redox sensitivity. In general, oxidizing conditions favour channel opening, while reducing conditions have the opposite effect. Thiol modification affects the channel sensitivity to its principal effectors, Ca2+, Mg2+ and ATP, and alters RyR protein interactions. Here, we give a brief account of the major findings and prevailing views in the field.

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