The Functional Role of the Conformational Changes in Arrestin Upon Activation

2017 ◽  
pp. 219-234
Author(s):  
Zhao Yang ◽  
Fan Yang ◽  
Anthony Nguen ◽  
Chuan Liu ◽  
Amy Lin ◽  
...  
Keyword(s):  
Conformational Changes ◽  
Functional Role

scholarly journals Functional role of rRNAs in plant translation system tested with antisense strategy.

1998 ◽  
Vol 45 (4) ◽  
pp. 1053-1066 ◽  
Author(s):  
M Nawrot ◽  
E Bohun ◽  
L Ksiazczak-Kus ◽  
A Sobkiewicz ◽  
J Polak ◽  
...  
Keyword(s):  
Conformational Changes ◽  
Plant Material ◽  
Functional Role ◽  
Protein Biosynthesis ◽  
Lupinus Luteus ◽  
Translation System ◽  
Specific Hybridization ◽  
26S Rrna ◽  
Structure And Activity

There are regions in rRNA which are evolutionary conserved and exposed on ribosomal surface. We selected in plant material (Lupinus luteus) two of them: the alpha-sarcin domain of 26S rRNA (L-rRNA) and C loop of 5S rRNA, to be further investigated using antisense oligomers as research tools. We found inhibition of the model polypeptide biosynthesis (up to 80%) due to specific hybridization of oligomers addressed to alpha-sarcin domain and loop C. Based on our results we present the evidence for the key role played by these regions of rRNAs during protein biosynthesis in plant system. According to our hypothesis, conformational changes of these two regions are synchronised and cooperative during transition of pre- to post-translocation state of the ribosome. The correlation of structure and activity of rRNA domains in translation is shown.

Cardiotoxins: Functional Role of Local Conformational Changes

2017 ◽  
Vol 57 (11) ◽  
pp. 2799-2810 ◽  
Author(s):  
Anastasia G. Konshina ◽  
Nikolay A. Krylov ◽  
Roman G. Efremov
Keyword(s):  
Conformational Changes ◽  
Functional Role

scholarly journals How do brassinosteroids activate their receptors?

2019 ◽  
Author(s):  
Alexander S. Moffett ◽  
Diwakar Shukla
Keyword(s):  
Conformational Changes ◽  
Functional Role ◽  
Conformational Dynamics ◽  
Growth Hormones ◽  
Dynamics Simulation ◽  
Leucine Rich Repeat ◽  
Plant Growth Hormones ◽  
Simulation Based ◽  
Large Conformational Change

AbstractBrassinosteroids (BRs) are an important class of plant growth hormones which signal through BRI1 and BAK1, leucine-rich repeat receptor-like kinases (LRR-RLKs). When bound to the BRI1 island domain, BRs act as a “molecular glue”, mediating interactions between BRI1 and BAK1 extracellular domains. However, it is unclear how much other factors contribute to BR-induced BRI1-BAK1 association, including stabilization of the BRI1 island domain and large conformational changes in BRI1. We use several molecular dynamics simulation-based methods to explore the contributions of each mechanism to BR-dependent Arabidopsis thaliana BRI1-BAK1 association. We find that specific BR interactions make major contributions to BRI1-BAK1 association free energy. BR binding stabilizes the BRI1 island domain, while BRI1 undergoes a large conformational change to form a secondary interface with BAK1. These results suggest that each mechanism plays a part in BR signal transduction while raising questions about the functional role of conformational dynamics in other LRR-RLKs.

Role of spectrin in membrane fusion and in shape change of human erythrocyte ghost

1978 ◽  
Vol 36 (2) ◽  
pp. 328-329
Author(s):  
Hideo Hayashi ◽  
Yoshikazu Hirai ◽  
John T. Penniston
Keyword(s):  
Conformational Changes ◽  
Human Erythrocyte ◽  
Shape Change ◽  
Membrane Surface ◽  
Slight Modification ◽  
Active Role ◽  
Main Role ◽  
Bank Blood ◽  
Human Erythrocyte Ghost

Spectrin is a membrane associated protein most of which properties have been tentatively elucidated. A main role of the protein has been assumed to give a supporting structure to inside of the membrane. As reported previously, however, the isolated spectrin molecule underwent self assemble to form such as fibrous, meshwork, dispersed or aggregated arrangements depending upon the buffer suspended and was suggested to play an active role in the membrane conformational changes. In this study, the role of spectrin and actin was examined in terms of the molecular arrangements on the erythrocyte membrane surface with correlation to the functional states of the ghosts.Human erythrocyte ghosts were prepared from either freshly drawn or stocked bank blood by the method of Dodge et al with a slight modification as described before. Anti-spectrin antibody was raised against rabbit by injection of purified spectrin and partially purified.

Expression and functional role of c-Kit and erbB2 in human hepatoblastoma.

2009 ◽  
Vol 221 (03) ◽  
Author(s):  
B Steiger ◽  
I Leuschner ◽  
D Denkhaus ◽  
D von Schweinitz ◽  
T Pietsch
Keyword(s):  
Functional Role

Presence and functional role of KiSS/KiSS-R system in pancreatic neuroendocrine tumors (panNETs) and its relationship with clinical features and tumor behavior

2018 ◽  
Author(s):  
Emilia Alors-Perez ◽  
Sergio Pedraza-Arevalo ◽  
Aura Herrera-Martinez ◽  
Angel J Diaz-Perez ◽  
Teresa Caro ◽  
...  
Keyword(s):  
Clinical Features ◽  
Neuroendocrine Tumors ◽  
Functional Role ◽  
Pancreatic Neuroendocrine Tumors
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