Risk of Venous Thromboembolism in Surgical Elderly Patients

2018 ◽  
pp. 65-78
Author(s):  
Anna Falanga ◽  
Viola Milesi
Keyword(s):  
Venous Thromboembolism ◽  
Elderly Patients

Comparison of Bleeding Risk Scores in Elderly Patients Receiving Extended Anticoagulation with Vitamin K Antagonists for Venous Thromboembolism

2021 ◽  
Author(s):  
Andrea N. Frei ◽  
Odile Stalder ◽  
Andreas Limacher ◽  
Marie Méan ◽  
Christine Baumgartner ◽  
...  
Keyword(s):  
Venous Thromboembolism ◽  
Elderly Patients ◽  
Vitamin K ◽  
Vitamin K Antagonists ◽  
Predictive Performance ◽  
Roc Curves ◽  
Bleeding Risk ◽  
Risk Scores ◽  
Likelihood Ratios ◽  
Risk Categories

Abstract Background In elderly patients with venous thromboembolism (VTE), the decision to extend anticoagulation beyond 3 months must be weighed against the bleeding risk. We compared the predictive performance of 10 clinical bleeding scores (VTE-BLEED, Seiler, Kuijer, Kearon, RIETE, ACCP, OBRI, HEMORR2HAGES, HAS-BLED, ATRIA) in elderly patients receiving extended anticoagulation for VTE. Methods In a multicenter Swiss cohort study, we analyzed 743 patients aged ≥65 years who received extended treatment with vitamin K antagonists after VTE. The outcomes were the time to a first major and clinically relevant bleeding. For each score, we classified patients into two bleeding risk categories (low/moderate vs. high). We calculated likelihood ratios and the area under the receiver operating characteristic (ROC) curve for each score. Results Over a median anticoagulation duration of 10.1 months, 45 patients (6.1%) had a first major and 127 (17.1%) a clinically relevant bleeding. The positive likelihood ratios for predicting major bleeding ranged from 0.69 (OBRI) to 2.56 (Seiler) and from 1.07 (ACCP) to 2.36 (Seiler) for clinically relevant bleeding. The areas under the ROC curves were poor to fair and varied between 0.47 (OBRI) and 0.70 (Seiler) for major and between 0.52 (OBRI) and 0.67 (HEMORR2HAGES) for clinically relevant bleeding. Conclusion The predictive performance of most clinical bleeding risk scores does not appear to be sufficiently high to identify elderly patients with VTE who are at high risk of bleeding and who may therefore not be suitable candidates for extended anticoagulation.

Antipsychotic Drug Use and the Risk of Venous Thromboembolism in Elderly Patients

2010 ◽  
Vol 30 (5) ◽  
pp. 526-530 ◽  
Author(s):  
Bart C. Kleijer ◽  
Eibert R. Heerdink ◽  
Toine C.G. Egberts ◽  
Paul A.F. Jansen ◽  
Rob J. van Marum
Keyword(s):  
Venous Thromboembolism ◽  
Drug Use ◽  
Elderly Patients ◽  
Antipsychotic Drug

scholarly journals Predictors and Outcomes of Recurrent Venous Thromboembolism in Elderly Patients

2018 ◽  
Vol 131 (6) ◽  
pp. 703.e7-703.e16 ◽  
Author(s):  
Sandro Lauber ◽  
Andreas Limacher ◽  
Tobias Tritschler ◽  
Odile Stalder ◽  
Marie Méan ◽  
...  
Keyword(s):  
Venous Thromboembolism ◽  
Elderly Patients ◽  
Recurrent Venous Thromboembolism

Derivation and validation of a novel bleeding risk score for elderly patients with venous thromboembolism on extended anticoagulation

2017 ◽  
Vol 117 (10) ◽  
Author(s):  
E. Seiler ◽  
A. Limacher ◽  
M. Mean ◽  
H.-J. Beer ◽  
J. Osterwalder ◽  
...  
Keyword(s):  
Venous Thromboembolism ◽  
Elderly Patients ◽  
Risk Score ◽  
Bleeding Risk

scholarly journals Polypharmacy is Associated with an Increased Risk of Bleeding in Elderly Patients with Venous Thromboembolism

2014 ◽  
Vol 30 (1) ◽  
pp. 17-24 ◽  
Author(s):  
Waltraud Leiss ◽  
Marie Méan ◽  
Andreas Limacher ◽  
Marc Righini ◽  
Kurt Jaeger ◽  
...  
Keyword(s):  
Venous Thromboembolism ◽  
Elderly Patients ◽  
Risk Of Bleeding ◽  
Increased Risk
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