Rapid Plasma Reagin (RPR) Test

2018 ◽  
pp. 31-34
Author(s):  
Rowa Yousef Alhabbab
Keyword(s):  
Rapid Plasma Reagin

scholarly journals P077 Evaluation of three automated nontreponemal Rapid Plasma Reagin (RPR) tests for the diagnosis of syphilis

2021 ◽  
Author(s):  
M Shukla ◽  
L Pereira ◽  
A Gaynor ◽  
Y Sun ◽  
D Edwards ◽  
...  
Keyword(s):  
Rapid Plasma Reagin

THE RAPID PLASMA REAGIN (CIRCLE) CARD TEST: A SCREENING TEST FOR SYPHILIS

1973 ◽  
Vol 1 (15) ◽  
pp. 737-739 ◽  
Author(s):  
M. F. Garner ◽  
J. L. Backhouse
Keyword(s):  
Screening Test ◽  
Rapid Plasma Reagin ◽  
Card Test

scholarly journals Investigation of the rapid immunochromatographic test performance in the diagnosis of syphilis; comparison of four serological methods

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Huseyin Agah Terzi ◽  
Ozlem Aydemir ◽  
Engin Karakece ◽  
Huseyin Hatipoglu ◽  
Mehmet Olmez ◽  
...  
Keyword(s):  
Test Performance ◽  
Gold Standard ◽  
Treponema Pallidum ◽  
Rapid Test ◽  
Immunochromatographic Test ◽  
Rapid Plasma Reagin ◽  
Serum Samples ◽  
Hemagglutination Assay ◽  
Predictive Values ◽  
Sensitivity Specificity

AbstractObjectivesTo test the performance of the newly available rapid test for syphilis, we compared it with Treponema pallidum hemagglutination assay (TPHA). Additionally, we investigated the performance of rapid plasma reagin (RPR) and chemiluminescence microparticle immunoassays (CMIA) at our laboratory using TPHA as a gold standard.MethodsThe serum samples of 595 patients with the pre-diagnosis of syphilis were studied by four serological methods. The sensitivity, specificity, and predictive values of RPR, CMIA, and syphilis rapid test were assessed by utilizing TPHA as a gold standard for the diagnosis of syphilis.ResultsOf the patients, 6.2% (37/595) had positive RPR, 5.5% (33/595) had positive CMIA, 5.5% (33/595) had a positive rapid immunochromatographic method and 5% (30/595) had positive TPHA. When TPHA results were taken as the reference, the sensitivity of the rapid test for syphilis was 100%, the specificity was 99.5%, PPV was 90.9%, and NPV was 100.0%.ConclusionsIt was observed that the rapid test for syphilis used in the study was quite successful, its cost was appropriate, and the test was very fast and easy to apply. At the same time, the agreement between syphilis rapid test and TPHA was found to be excellent.

scholarly journals Clinical Performance of the BioPlex 2200 Syphilis Total & RPR Assay at a Tertiary Medical Center with a High Rate of Syphilis

2018 ◽  
Vol 57 (1) ◽  
Author(s):  
Merih T. Tesfazghi ◽  
Neil W. Anderson ◽  
Ann M. Gronowski ◽  
Melanie L. Yarbrough
Keyword(s):  
Clinical Performance ◽  
Medical Center ◽  
High Volume ◽  
High Rate ◽  
Rapid Plasma Reagin ◽  
Antibody Absorption ◽  
Traditional Algorithm ◽  
Syphilis Screening ◽  
Manual Methods ◽  
Positive Population

ABSTRACT Manual treponemal and nontreponemal serologic testing has historically been used for the diagnosis of syphilis. This approach is simple and reproducible but labor intensive. Recently, the FDA cleared the fully automated BioPlex 2200 Syphilis Total & RPR assay for the detection of treponemal and nontreponemal antibodies. We evaluated the clinical performance of this assay at a tertiary medical center with a high syphilis prevalence. Prospective consecutively collected (n = 400) and known RPR-positive (n = 100) specimens were compared using predicate manual rapid plasma reagin (RPR) and fluorescent treponemal antibody absorption (FTA) methods and the BioPlex 2200 Syphilis Total & RPR assay. Positive and negative percent agreements (PPA and NPA, respectively) between the assays were calculated. The PPA and NPA between the manual and BioPlex 2200 RPR results for the prospective population were 85% (17/20; 95% confidence interval [CI], 69% to 100%) and 98% (373/380; 95% CI, 97% to 99%), respectively. The PPA for the manual RPR-positive population was 88% (88/100; 95% CI, 82% to 94%). Overall, the manual and BioPlex 2200 RPR titers demonstrated 78% (99/127) concordance within ±1 dilution and 94% (120/127) within ±2 dilutions. An interpretation of the syphilis serologic profile using the traditional algorithm showed a concordance of 99.5% in the prospective population and 85% in the manual RPR-positive cohort. The performance of the BioPlex 2200 Syphilis Total & RPR assay is comparable to those of manual methods. The high NPA of this assay combined with the ability to automate a historically labor-intensive assay is an appealing attribute for syphilis screening in a high-volume laboratory.

Evaluation of a Digital Flocculation Reader for the Rapid Plasma Reagin Test for the Serological Diagnosis of Syphilis

2012 ◽  
Vol 39 (3) ◽  
pp. 223-225 ◽  
Author(s):  
Arnold R. Castro ◽  
David D. Binks ◽  
Danny L. Raymer ◽  
Susan E. Kikkert ◽  
Heather A. Jost ◽  
...  
Keyword(s):  
Serological Diagnosis ◽  
Rapid Plasma Reagin

scholarly journals Evaluation of reagin screen, a new serological test for syphilis

1976 ◽  
Vol 4 (2) ◽  
pp. 145-150
Author(s):  
J D Dyckman ◽  
R D Wende ◽  
D Gantenbein ◽  
R P Williams
Keyword(s):  
Research Laboratory ◽  
Serological Test ◽  
Venereal Disease ◽  
The Other ◽  
Screening Tests ◽  
Venereal Disease Research Laboratory ◽  
Rapid Plasma Reagin ◽  
Disease Research ◽  
Antibody Absorption

A total of 1,020 serum and plasma specimens were tested using the Venereal Disease Research Laboratory (VDRL), Rapid Plasma Reagin (RPR) card, Reagin Screen (RST) and Fluorescent Treponemal Antibody-Absorption (FTA-ABS) tests. In 257 normal patients, all screening tests were nonreactive; the FTA-ABS test was reactive for one patient. In 588 patients with treated and untreated syphilis, the RST results were 91.7% in agreement with the VDRL and RPR results. In 175 patients with diseases that cause biological false reactions, the RST was 94% in agreement with the other screening tests. The titer of the RST was within one dilution of the corresponding VDRL titer in 91.7% of the 360 speciments tested and within one dilution of the RPR titer in 96.9% of 358 specimens quantitated by both tests.

scholarly journals Qualitative evaluation of the reagin screen test

1976 ◽  
Vol 4 (1) ◽  
pp. 16-18
Author(s):  
D A Black ◽  
P E Ray ◽  
B L Therrell
Keyword(s):  
False Negative ◽  
Qualitative Evaluation ◽  
Screen Test ◽  
Rapid Plasma Reagin ◽  
Disease Research ◽  
Procedural Training ◽  
Slide Test ◽  
Preliminary Study ◽  
Card Test ◽  
Total Agreement

After a preliminary study of 557 sera used as a procedural training exercise, the Reagin screen test (RST) for the macroscopic detection of reagin (as an aid to detecting syphilis) was qualitatively compared to the rapid plasma Reagin (RPR) (circle) card test and Veneral Disease Research Laboratory (VDRL) slide test on 435 random portions of sera using fluorescent treponemal antibody adsorption (FTA-ABS) results as a comparative base. A comparison of total agreement (positive and negative) with the FTA-ABS results led to the following order. RPRCT (I5.5%), VDRL (79.8%), and RST (74.5%). Of the total samples shown to be reactive by the FTA-ABS procedure, the percentage of these interpreted as nonreactive (i.e., "false negative") by the procedures compared was considerably higher with the RST procedure (29.3%) than with either the RPRCT (10.9%) or the VDRL (7.1%) procedures. Minor problems encountered with procedural techniques are also mentioned.

scholarly journals Use of the Treponema pallidum-specific captia syphilis IgG assay in conjunction with the rapid plasma reagin to test for syphilis.

1997 ◽  
Vol 35 (5) ◽  
pp. 1141-1143 ◽  
Author(s):  
B S Reisner ◽  
L M Mann ◽  
C A Tholcken ◽  
R T Waite ◽  
G L Woods
Keyword(s):  
Treponema Pallidum ◽  
Rapid Plasma Reagin

The Laboratory Impact of Changing Syphilis Screening From the Rapid-Plasma Reagin to a Treponemal Enzyme Immunoassay: A Case-study From the Greater Toronto Area

2011 ◽  
Vol 38 (3) ◽  
pp. 190-196 ◽  
Author(s):  
Sharmistha Mishra ◽  
Marie-Claude Boily ◽  
Victoria Ng ◽  
Wayne L. Gold ◽  
Tom Okura ◽  
...  
Keyword(s):  
Enzyme Immunoassay ◽  
Rapid Plasma Reagin ◽  
Greater Toronto Area ◽  
Syphilis Screening
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