Motor Cortex Stimulation for Parkinson’s Disease

2009 ◽  
pp. 1679-1690 ◽  
Author(s):  
M. Meglio ◽  
B. Cioni
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Motor Cortex ◽  
Motor Cortex Stimulation

scholarly journals Extradural Motor Cortex Stimulation in Parkinson’s Disease: Long-Term Clinical Outcome

2021 ◽  
Vol 11 (4) ◽  
pp. 416
Author(s):  
Carla Piano ◽  
Francesco Bove ◽  
Delia Mulas ◽  
Enrico Di Stasio ◽  
Alfonso Fasano ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Motor Cortex ◽  
Clinical Outcome ◽  
Motor Cortex Stimulation ◽  
Dopaminergic Therapy

Previous investigations have reported on the motor benefits and safety of chronic extradural motor cortex stimulation (EMCS) for patients with Parkinson’s disease (PD), but studies addressing the long-term clinical outcome are still lacking. In this study, nine consecutive PD patients who underwent EMCS were prospectively recruited, with a mean follow-up time of 5.1 ± 2.5 years. As compared to the preoperatory baseline, the Unified Parkinson’s Disease Rating Scale (UPDRS)-III in the off-medication condition significantly decreased by 13.8% at 12 months, 16.1% at 18 months, 18.4% at 24 months, 21% at 36 months, 15.6% at 60 months, and 8.6% at 72 months. The UPDRS-IV decreased by 30.8% at 12 months, 22.1% at 24 months, 25% at 60 months, and 36.5% at 72 months. Dopaminergic therapy showed a progressive reduction, significant at 60 months (11.8%). Quality of life improved by 18.0% at 12 months, and 22.4% at 60 months. No surgical complication, cognitive or behavioral change occurred. The only adverse event reported was an infection of the implantable pulse generator pocket. Even in the long-term follow-up, EMCS was shown to be a safe and effective treatment option in PD patients, resulting in improvements in motor symptoms and quality of life, and reductions in motor complications and dopaminergic therapy.

Motor cortex stimulation for Parkinson's disease: a modelling study

2012 ◽  
Vol 9 (5) ◽  
pp. 056005 ◽  
Author(s):  
Daphne G M Zwartjes ◽  
Tjitske Heida ◽  
Hans K P Feirabend ◽  
Marcus L F Janssen ◽  
Veerle Visser-Vandewalle ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Motor Cortex ◽  
Motor Cortex Stimulation ◽  
Modelling Study

Cerebral activity modulation by extradural motor cortex stimulation in Parkinson's disease: a perfusion SPECT study

2007 ◽  
Vol 0 (0) ◽  
pp. 071203214007007-???
Author(s):  
R. Cilia ◽  
G. Marotta ◽  
A. Landi ◽  
I. U. Isaias ◽  
F. Vergani ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Motor Cortex ◽  
Motor Cortex Stimulation ◽  
Cerebral Activity ◽  
Perfusion Spect

Akinesia in Parkinson's disease. II. Effects of subthreshold repetitive transcranial motor cortex stimulation

Neurology ◽  
1994 ◽  
Vol 44 (5) ◽  
pp. 892-892 ◽  
Author(s):  
A. Pascual-Leone ◽  
J. Valls-Sole ◽  
J. P. Brasil-Neto ◽  
A. Cammarota ◽  
J. Grafman ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Motor Cortex ◽  
Motor Cortex Stimulation

High frequency extradural motor cortex stimulation transiently improves axial symptoms in a patient with Parkinson's disease

2008 ◽  
Vol 23 (13) ◽  
pp. 1916-1919 ◽  
Author(s):  
Alfonso Fasano ◽  
Carla Piano ◽  
Celestino De Simone ◽  
Beatrice Cioni ◽  
Daniela Di Giuda ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Motor Cortex ◽  
High Frequency ◽  
Motor Cortex Stimulation ◽  
Axial Symptoms

scholarly journals Extradural Motor Cortex Stimulation might improve episodic and working memory in patients with Parkinson’s disease

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Carla Piano ◽  
Marco Ciavarro ◽  
Francesco Bove ◽  
Daniela Di Giuda ◽  
Fabrizio Cocciolillo ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Working Memory ◽  
Parkinson's Disease ◽  
Motor Cortex ◽  
Episodic Memory ◽  
Memory Task ◽  
Motor Symptoms ◽  
Motor Cortex Stimulation ◽  
Short Term ◽  
Verbal Episodic Memory

Abstract Electric Extradural Motor Cortex Stimulation (EMCS) is a neurosurgical procedure suggested for treatment of patients with advanced Parkinson’s disease (PD). We report two PD patients treated by EMCS, who experienced worsening of motor symptoms and cognition 5 years after surgery, when EMCS batteries became discharged. One month after EMCS restoration, they experienced a subjective improvement of motor symptoms and cognition. Neuropsychological assessments were carried out before replacement of batteries (off-EMCS condition) and 6 months afterward (on-EMCS condition). As compared to off-EMCS condition, in on-EMCS condition both patients showed an improvement on tasks of verbal episodic memory and backward spatial short-term/working memory task, and a decline on tasks of selective visual attention and forward spatial short-term memory. These findings suggest that in PD patients EMCS may induce slight beneficial effects on motor symptoms and cognitive processes involved in verbal episodic memory and in active manipulation of information stored in working memory.

Minimally invasive motor cortex stimulation for Parkinson's disease

2016 ◽  
Vol 61 (1) ◽  
Author(s):  
Angelo Lavano ◽  
Giusy Guzzi ◽  
Marisa De Rose ◽  
Mary Romano ◽  
Attilio Della Torre ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Motor Cortex ◽  
Minimally Invasive ◽  
Motor Cortex Stimulation

scholarly journals Motor Cortex Stimulation in Parkinson's Disease

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Marisa De Rose ◽  
Giusy Guzzi ◽  
Domenico Bosco ◽  
Mary Romano ◽  
Serena Marianna Lavano ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Motor Cortex ◽  
Motor Cortex Stimulation ◽  
Plate Electrode ◽  
Quality Of Life Scale ◽  
Life Scale ◽  
Axial Symptoms

Motor Cortex Stimulation (MCS) is less efficacious than Deep Brain Stimulation (DBS) in Parkinson's disease. However, it might be proposed to patients excluded from DBS or unresponsive to DBS. Ten patients with advanced PD underwent unilateral MCS contralaterally to the worst clinical side. A plate electrode was positioned over the motor cortex in the epidural space through single burr hole after identification of the area with neuronavigation and neurophysiological tests. Clinical assessment was performed by total UPDRS, UPDRS III total, UPDRS III-items 27–31, UPDRS IV, and UPDRS II before implantation in off-medication and on-medication states and after surgery at 1, 3, 6, 12, 18, 24, and 36 months in on-medication/on-stimulation and off-medication/on-stimulation states. We assessed changes of quality of life, throughout the Parkinson's disease quality of life scale (PDQoL-39), and the dose of anti-Parkinson's disease medications, throughout the Ldopa equivalent daily dose (LEDD). During off-medication state, we observed moderate and transitory reduction of total UPDRS and UPDRS total scores and significant and long-lasting improvement in UPDRS III items 27–31 score for axial symptoms. There was marked reduction of UPDRS IV score and LEDD. PDQL-39 improvement was also significant. No important complications and adverse events occurred.

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