Ion Channels, Cell Volume, Cell Proliferation and Apoptotic Cell Death

2008 ◽  
pp. 69-84 ◽  
Author(s):  
Florian Lang ◽  
Erich Gulbins ◽  
Ildiko Szabo ◽  
Alexey Vereninov ◽  
Stephan M. Huber
Keyword(s):  
Cell Proliferation ◽  
Cell Death ◽  
Ion Channels ◽  
Cell Volume ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death ◽  
Volume Cell

Ion Channels and Cell Volume in Regulation of Cell Proliferation and Apoptotic Cell Death

2006 ◽  
pp. 142-160 ◽  
Author(s):  
Florian Lang ◽  
Ekaterina Shumilina ◽  
Markus Ritter ◽  
Erich Gulbins ◽  
Alexey Vereninov ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Cell Death ◽  
Ion Channels ◽  
Cell Volume ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death

Ion Channels, Cell Volume, and Apoptotic Cell Death

1998 ◽  
Vol 8 (6) ◽  
pp. 285-292 ◽  
Author(s):  
F. Lang ◽  
A. Lepple-Wienhues ◽  
M. Paulmichl ◽  
I. Szabó ◽  
D. Siemen ◽  
...  
Keyword(s):  
Cell Death ◽  
Ion Channels ◽  
Cell Volume ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death

Ion Channels in Cell Proliferation and Apoptotic Cell Death

2005 ◽  
Vol 205 (3) ◽  
pp. 147-157 ◽  
Author(s):  
F. Lang ◽  
M. Föller ◽  
K.S. Lang ◽  
P.A. Lang ◽  
M. Ritter ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Cell Death ◽  
Ion Channels ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death

Cell Volume in Cell Proliferation and Apoptotic Cell Death

1998 ◽  
pp. 158-168 ◽  
Author(s):  
F. Lang ◽  
A. Lepple-Wienhues ◽  
I. Szab� ◽  
D. Siemen ◽  
E. Gulbins
Keyword(s):  
Cell Proliferation ◽  
Cell Death ◽  
Cell Volume ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death

Cell Volume in the Regulation of Cell Proliferation and Apoptotic Cell Death

2000 ◽  
Vol 10 (5-6) ◽  
pp. 417-428 ◽  
Author(s):  
Florian Lang ◽  
Markus Ritter ◽  
Nikita Gamper ◽  
Stephan Huber ◽  
Sophie Fillon ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Cell Death ◽  
Cell Volume ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death

Cell volume and the regulation of apoptotic cell death

2004 ◽  
Vol 17 (5) ◽  
pp. 473-480 ◽  
Author(s):  
Florian Lang ◽  
Erich Gulbins ◽  
Ildiko Szabo ◽  
Albrecht Lepple-Wienhues ◽  
Stephan M. Huber ◽  
...  
Keyword(s):  
Cell Death ◽  
Cell Volume ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death

Cell Volume Regulatory Ion Channels in Cell Proliferation and Cell Death

2007 ◽  
pp. 209-225 ◽  
Author(s):  
Florian Lang ◽  
Michael Föller ◽  
Karl Lang ◽  
Philipp Lang ◽  
Markus Ritter ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Cell Death ◽  
Ion Channels ◽  
Cell Volume

C-Myc Is Required for Acute but Not for Chronic Hematopoietic Malignances in Pten-Null Mice.

Blood ◽  
2009 ◽  
Vol 114 (22) ◽  
pp. 1632-1632
Author(s):  
Yinshi Guo ◽  
Christopher Seet ◽  
Chao Niu ◽  
Peter Breslin ◽  
Shubin Zhang ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Cell Death ◽  
Conflicts Of Interest ◽  
Apoptotic Cell ◽  
Akt Signaling ◽  
Apoptotic Cell Death ◽  
Lymphocytic Leukemia ◽  
Mutant Mice ◽  
Myelogenous Leukemia ◽  
Hematopoietic Stem

Abstract Abstract 1632 Poster Board I-658 c-Myc, the product of an oncogene, is a common target of most leukemic oncoproteins. Deregulation of c-Myc is commonly found in human leukemic blasts. Transgenic over-expression of c-Myc induces myeloid, erythroid, and lymphocytic leukemia in mice, however whether c-Myc is absolutely required for leukemogenesis has not yet been addressed. Pten, a tumor-suppressing phosphatase, inhibits cell proliferation and promotes apoptotic cell death through repression of PI3K-Akt signaling. Inactivating mutations of Pten and deregulation of PI3K/Akt signaling are both involved in the development of both chronic and acute hematopoietic malignances. Mice with Pten deletions in hematopoietic stem cells (HSCs) develop myeloproliferative disorders (MPD) followed by acute T lymphocytic or myeloid leukemia, reminiscent of disease progression in human chronic myelogenous leukemia. Mice with Pten deletions in lymphocytes develop lymphadenopathy (due to a chronic polyclonal lymphoproliferative disorder) as well as CD4+ T lymphocytic lymphoma. The appearance of these diseases in one animal model provides an opportunity to study the pathogenesis of multiple diseases simultaneously. To study whether c-Myc is required for the development of these hematopoietic disorders in Pten-mutant mice, we generated inducible Pten and c-Myc double-knockout mice (Pten-/-c-Myc-/-). By comparing the hematopoietic phenotypes of the Pten-/-c-Myc-/- mice with those of Pten-mutant (Pten-/-) mice, we found that both sets of mice developed MPD and lymphadenopathy, however none of the compound-mutant mice developed acute leukemia or lymphoma. Interestingly, in contrast to the MPD which developed in Pten-/- mice, which is dominated by granulocytes, megakaryocytes predominate in the MPD of Pten-/-c-Myc-/- mice. We have concluded that c-Myc is required for the development of both T lymphocytic lymphoma and the acute leukemic transformation of Pten-/- MPD, but is not essential for the development of chronic myeloid or lymphoid proliferative disorders. Our study suggests that deregulation of PI3K/Akt signaling in Pten-mutant hematopoietic cells protects these cells from apoptotic cell death, which results in chronic proliferative disorders, while the deregulation of c-Myc resulting from additional mutations promotes hematopoietic cell proliferation and blockage of maturation, and is absolutely required for the development of acute hematopoietic malignances. Disclosures No relevant conflicts of interest to declare.

scholarly journals Melatonin decreases cell proliferation, impairs myogenic differentiation and triggers apoptotic cell death in rhabdomyosarcoma cell lines

2015 ◽  
Vol 34 (1) ◽  
pp. 279-287 ◽  
Author(s):  
SILVIA CODENOTTI ◽  
MICHELA BATTISTELLI ◽  
SABRINA BURATTINI ◽  
SARA SALUCCI ◽  
ELISABETTA FALCIERI ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Cell Death ◽  
Cell Lines ◽  
Apoptotic Cell ◽  
Myogenic Differentiation ◽  
Apoptotic Cell Death ◽  
Rhabdomyosarcoma Cell
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