Functions of Human Cytomegalovirus Tegument Proteins Prior to Immediate Early Gene Expression

2008 ◽  
pp. 101-115 ◽  
Author(s):  
R. F. Kalejta
Keyword(s):  
Gene Expression ◽  
Human Cytomegalovirus ◽  
Immediate Early Gene ◽  
Early Gene ◽  
Immediate Early ◽  
Early Gene Expression ◽  
Tegument Proteins

scholarly journals Repression of human cytomegalovirus major immediate early gene expression in a monocytic cell line

1992 ◽  
Vol 73 (2) ◽  
pp. 433-435 ◽  
Author(s):  
J. H. Sinclair ◽  
J. Baillie ◽  
L. A. Bryant ◽  
J. A. Taylor-Wiedeman ◽  
J. G. P. Sissons
Keyword(s):  
Gene Expression ◽  
Cell Line ◽  
Human Cytomegalovirus ◽  
Immediate Early Gene ◽  
Early Gene ◽  
Immediate Early ◽  
Monocytic Cell ◽  
Monocytic Cell Line ◽  
Early Gene Expression

scholarly journals Inhibition of human cytomegalovirus immediate early gene expression and growth by a novel RNase P ribozyme variant

PLoS ONE ◽  
2017 ◽  
Vol 12 (10) ◽  
pp. e0186791 ◽  
Author(s):  
Xu Sun ◽  
Weijie Chen ◽  
Lingling He ◽  
Jingxue Sheng ◽  
Yujun Liu ◽  
...  
Keyword(s):  
Gene Expression ◽  
Human Cytomegalovirus ◽  
Rnase P ◽  
Immediate Early Gene ◽  
Early Gene ◽  
Immediate Early ◽  
Early Gene Expression

Human cytomegalovirus immediate-early-gene expression disrupts embryogenesis in transgenic Drosophila

2007 ◽  
Vol 17 (1) ◽  
pp. 105-119 ◽  
Author(s):  
Racheli Steinberg ◽  
Yonat Shemer-Avni ◽  
Noa Adler ◽  
Shira Neuman-Silberberg
Keyword(s):  
Gene Expression ◽  
Human Cytomegalovirus ◽  
Immediate Early Gene ◽  
Early Gene ◽  
Immediate Early ◽  
Early Gene Expression ◽  
Transgenic Drosophila

scholarly journals Inactivating a Cellular Intrinsic Immune Defense Mediated by Daxx Is the Mechanism through Which the Human Cytomegalovirus pp71 Protein Stimulates Viral Immediate-Early Gene Expression

2006 ◽  
Vol 80 (8) ◽  
pp. 3863-3871 ◽  
Author(s):  
Ryan T. Saffert ◽  
Robert F. Kalejta
Keyword(s):  
Gene Expression ◽  
Human Cytomegalovirus ◽  
Immediate Early Gene ◽  
Nuclear Body ◽  
Immune Defense ◽  
Early Gene ◽  
Immediate Early ◽  
Innate Immune Responses ◽  
Early Gene Expression ◽  
Infected Cells

ABSTRACT Human cytomegalovirus (HCMV) masterfully evades adaptive and innate immune responses, allowing infection to be maintained and periodically reactivated for the life of the host. Here we show that cells also possess an intrinsic immune defense against HCMV that is disarmed by the virus. In HCMV-infected cells, the promyelocytic leukemia nuclear body (PML-NB) protein Daxx silences viral immediate-early gene expression through the action of a histone deacetylase. However, this antiviral tactic is efficiently neutralized by the viral pp71 protein, which is incorporated into virions, delivered to cells upon infection, and mediates the proteasomal degradation of Daxx. This work demonstrates the mechanism through which pp71 activates viral immediate-early gene expression in HCMV-infected cells. Furthermore, it provides insight into how a PML-NB protein institutes an intrinsic immune defense against a DNA virus and how HCMV pp71 inactivates this defense.

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