Novel Dynamic Bioreactor System for Heart Valve Cultivation under Echocardiographic Control

2009 ◽  
pp. 237-240
Author(s):  
S. Kreitz ◽  
G. Dohmen ◽  
S. Diamantouros ◽  
J. Frese ◽  
T. C. Flanagan ◽  
...  
Keyword(s):  
Heart Valve ◽  
Bioreactor System

Flow Patterns in a Flow-Stretch-Flexure Bioreactor System: Implications for the Conditioning of Engineered Heart Valve Tissue

2009 ◽  
Author(s):  
Sharan Ramaswamy ◽  
David E. Schmidt ◽  
Steven M. Boronyak ◽  
Michael S. Sacks
Keyword(s):  
Heart Valve ◽  
Flow Patterns ◽  
Tissue Formation ◽  
Local Flow ◽  
Tissue Scaffold ◽  
Mechanical Conditioning ◽  
Valve Tissue ◽  
Combined Flow ◽  
Heart Valve Tissue ◽  
Bioreactor System

In heart valve tissue engineering, there is general agreement that appropriate mechanical conditioning may provide the necessary stimuli to promote proper tissue formation [1–3]. For example, in combined flow-flexure-stretch (FSF) studies conducted in our laboratory [4], we demonstrated that flow or flexure bio-mechanical conditioning alone only produced marginally enhanced mass and quality of the engineered tissue. However, combined fluid and flexural stresses resulted in substantially larger de-novo synthesized tissue mass accumulations rates. Interestingly, surface fluid induced stresses acting on the forming tissue/scaffold were the sole difference in the mechanical environment under combined stimulation regimes. However, combined flow and flexural modes of biomechanical conditioning produce highly complex local flow patterns. Understanding these patterns can help identify specific fluid-induced shear characteristics that can potentially be responsible for improving tissue formation in tissue engineered heart valves (TEHVs). In the present study, we developed a computational fluid dynamic (CFD) model to simulate the motion of rectangular scaffold strips housed in the bioreactor. In order to maximize the benefits of flow-based conditioning at physiological scales that emulates the native valve environment, we also present our efforts in designing a new FSF bioreactor system.

Choosing A Prosthetic Heart Valve

1991 ◽  
Vol 9 (2) ◽  
pp. 329-338 ◽  
Author(s):  
Jorge A. Wernly ◽  
Michael H. Crawford
Keyword(s):  
Heart Valve ◽  
Prosthetic Heart Valve

Impact of protein coating strategies on the re-endothelialization of biological heart valve scaffolds

2009 ◽  
Vol 56 (S 01) ◽  
Author(s):  
P Akhyari ◽  
H Ziegler ◽  
P Mambou ◽  
M Barth ◽  
S Hoffmann ◽  
...  
Keyword(s):  
Heart Valve ◽  
Protein Coating

Biological heart valve prosthesis in patients requiring chronic dialysis

2009 ◽  
Vol 56 (S 01) ◽  
Author(s):  
A Böning ◽  
S Haberer ◽  
UP Rosendahl ◽  
I Florath ◽  
JC Ennker
Keyword(s):  
Heart Valve ◽  
Chronic Dialysis ◽  
Heart Valve Prosthesis ◽  
Valve Prosthesis

Transcatheter aortic heart valve (THV) implantation of Edwards Sapien™ bioprothesis – using a mobile x-ray-system or a hybrid-OR?

2010 ◽  
Vol 58 (S 01) ◽  
Author(s):  
H Schröfel ◽  
G Schymik ◽  
A Würth ◽  
V Elsner ◽  
BD Gonska ◽  
...  
Keyword(s):  
Heart Valve ◽  
X Ray ◽  
Aortic Heart Valve ◽  
Edwards Sapien

Cannabis sativa L. Micropropagation in Temporary Immersion Bioreactor System

Planta Medica ◽  
2010 ◽  
Vol 76 (05) ◽  
Author(s):  
H Lata ◽  
S Chandra ◽  
IA Khan ◽  
MA ElSohly
Keyword(s):  
Cannabis Sativa ◽  
Temporary Immersion Bioreactor ◽  
Temporary Immersion ◽  
Bioreactor System

Human liver cell cultivation for long-term in vitro toxicity studies in a miniaturized multi-compartment 3D bioreactor system

2011 ◽  
Vol 49 (01) ◽  
Author(s):  
SA Hoffmann ◽  
M Lübberstedt ◽  
U Müller-Vieira ◽  
D Knobeloch ◽  
A Nüssler ◽  
...  
Keyword(s):  
Liver Cell ◽  
Human Liver ◽  
In Vitro Toxicity ◽  
Cell Cultivation ◽  
Toxicity Studies ◽  
Human Liver Cell ◽  
Bioreactor System
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