Nasal Polyps in Cystic Fibrosis

The aim of this study was to evaluate prevalence of chronic rhinosinusitis (CRS) and nasal polyps in adult patients with cystic fibrosis (CF) in Russian Federation. Additionally, we investigated the clinical course of CRS and developed the optimal therapeutic strategy.Methods. Three hundred and forty eight CF patients were involved in the study. Physical examination, computed tomography (CT) of paranasal sinuses and audiometry, if needed, were used. CRS and bilateral nasal polyps were diagnosed in 28 patients. Nasal endoscopy, SNOT-20 questionnaire, rhinomanometry, micro - biological examination of sputum and mucus from paranasal sinuses (obtained during puncture or surgery), spirometry, and measurement of serum markers of inflammation were used. Endoscopic sinus surgery was used in 14 patients (the group 1) and others were treated non-surgically (the group 2). Both group were treated during 6 months using intranasal mometasone, mucolytics and antibiotics via PARI SINUSTM nebulizer.Results. An improvement in symptoms, CT signs, rhinomanometry parameters and endoscopic signs was seen in both groups after treatment and was more prominent in the surgical treatment group compared to the non-surgical treatment group. Bacterial load reduction in nasal sinuses, decrease in the rate of pulmonary disease exacerbations, and an improvement in oxygen blood saturation were found in the surgical treatment group only. Treatment of CRS did not affect lung function, sputum microbiology and serum inflammatory markers.Conclusion. Endoscopic sinus surgery followed by intranasal mucolytics and antibacterials is an effective and well-tolerated treatment in adult CF patients with CRS.

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Cystic Fibrosis: The Sense of Smell

American Journal of Rhinology and Allergy ◽

10.1177/1945892419870450 ◽

2019 ◽

Vol 34 (1) ◽

pp. 35-42 ◽

Cited By ~ 4

Author(s):

Antonella M. Di Lullo ◽

Paola Iacotucci ◽

Marika Comegna ◽

Felice Amato ◽

Pasquale Dolce ◽

...

Keyword(s):

Quality Of Life ◽

Cystic Fibrosis ◽

Facial Pain ◽

Nasal Polyps ◽

Nasal Congestion ◽

Nasal Discharge ◽

Upper Airways ◽

Multisystem Disease ◽

Mean Values

Background Cystic fibrosis (CF) is a multisystem disease that involves the upper airways with chronic rhinosinusitis (CRS) causing nasal congestion, rhinorrhea, mouth breathing, facial pain, and olfactory dysfunction. Twelve percent to 71% of CF patients report smelling alterations with an impact on nutrition and quality of life. Objectives The goal was to study olfaction performance in CF patients with CRS that worsens quality of life. Methods A total of 121 subjects were enrolled in this study. Seventy-one had CF and underwent ear, nose, and throat evaluation with nasal endoscopy, sinonasal outcome test 22 (SNOT-22), visual analog scale (VAS), and “Sniffin’ Sticks.” Fifty subjects were age-matched with healthy controls. Results All 71 CF patients were affected by CRS; 59 of 71 (83.1%) had CRS without nasal polyps and 12 of 71 (16.9%) had CRS with early nasal polyps. None of the 50 controls had CRS. Total SNOTT-22 mean values in the 71 CF patients were 38.10 ± 21.08 points. If considering only the 59 CF patients without nasal polyps, the SNOTT-22 mean value was 36.76 ± 21.52 points. Moreover, based on the VAS scores, the degree of nasal symptoms was classified as mild for facial pain, smell alteration, nasal discharge, and sneezing and resulted in moderate symptoms for nasal blockage and headache. Among the CF patients, 55 of 71 (76.5%) declared to be normosmic, while the smelling ability assessed by “Sniffin’ Sticks” showed that only 4 of 71 (5.63%) were normosmic, 58 (81.69%) were hyposmic, and 9 (12.68%) were anosmic. In the controls, 41(82%) were normosmic, 9 (18%) were hyposmic, and none were reported to be anosmic ( P < .001). Conclusions We confirm that most CF patients have a relevant olfactory impairment, although only a low percentage declares such alteration. A careful evaluation with simple and rapid tests helps to select the patients who may benefit from specific therapies.

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WS01.3 Chronic rhinosinusitis with nasal polyps (CRSwNP) in adult cystic fibrosis patients: optimal medical and surgical strategies

Journal of Cystic Fibrosis ◽

10.1016/s1569-1993(20)30167-3 ◽

2020 ◽

Vol 19 ◽

pp. S1-S2

Author(s):

G. Shumkova ◽

E. Amelina ◽

V. Svistushkin ◽

S. Krasovskiy ◽

E. Sinkov

Keyword(s):

Cystic Fibrosis ◽

Chronic Rhinosinusitis ◽

Nasal Polyps ◽

Surgical Strategies

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Upper Airway Findings and Markers of Lung Disease Progression in Patients with Cystic Fibrosis

International Archives of Otorhinolaryngology ◽

10.1055/s-0039-3402434 ◽

2020 ◽

Vol 24 (04) ◽

pp. e434-e437

Author(s):

Luciane Mazzini Steffen ◽

Luise Sgarabotto Pezzin ◽

Natassia Sulis ◽

Nedio Steffen ◽

Leonardo Araujo Pinto

Keyword(s):

Cystic Fibrosis ◽

Lung Disease ◽

Disease Progression ◽

Nasal Polyps ◽

Nasal Swab ◽

Statistical Significance ◽

Upper Airway ◽

Forced Expiratory Volume ◽

Upper Respiratory Tract ◽

Upper Airways

Abstract Introduction Cystic fibrosis (CF) is a genetic disease that limits the quality of life mainly due to respiratory symptoms. The relationship between findings of the upper airways and CF lung disease is not yet completely understood. Objective The aim of the present study is to describe the most frequent nasal findings and pathogens in patients with CF and investigate the association between the findings of the upper respiratory tract and markers of lung disease progression. Methods Retrospective study in patients with CF from the Pediatric Pulmonology Department who underwent otorhinolaryngological evaluation between 2015 and 2017. Nasal endoscopy and nasal swab collection were part of the evaluation. The severity markers used were: percentage of predicted forced expiratory volume in the first second (FEV1%), body mass index (BMI) and the Shwachman-Kulczycki (SK) clinical score. Results A total of 48 patients with CF were included. The mean of the predicted percentage of FEV1% was 83.36 ± 30.04. The average 14 and SK score 89.11 ± 10.50. The bacteriology of the nasal swab was positive in 27 (54.1%) patients. Staphylococcus aureus was positive in 18 patients, Pseudomonas aeruginosa in 5, Pseudomonas cepacea in 3 and Stenotrophomonas maltophila in 1 patient. Nasal polyps were found in nine participants. Nasal polyps were found in nine participants and were associated with lower SK score. Conclusion The pathogens found in the upper airway were, in order: S. aureus, P. aeruginosa, P. cepacea e S. maltophila. The presence of polyps in the nasal cavity showed statistical significance and appears to have association with the prognostic factor measured by the SK score.

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Glycohistochemical Characteristics of Nasal Polyps From Patients With and Without Cystic Fibrosis

Archives of Otolaryngology - Head and Neck Surgery ◽

10.1001/archotol.126.6.769 ◽

2000 ◽

Vol 126 (6) ◽

pp. 769 ◽

Cited By ~ 1

Author(s):

Sergio Hassid ◽

Georges Choufani ◽

Christine Decaestecker ◽

Carine Delbrouck ◽

Sandra Dawance ◽

...

Keyword(s):

Cystic Fibrosis ◽

Nasal Polyps

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Nasal polyps and sinusitis in children with cystic fibrosis.

The Journal of Laryngology & Otology ◽

10.1017/s0022215100109983 ◽

1989 ◽

Vol 103 (8) ◽

pp. 753-755 ◽

Cited By ~ 31

Author(s):

A. B. Drake-Lee ◽

D. W. Morgan

Keyword(s):

Cystic Fibrosis ◽

Nasal Polyps

AbstractEighteen children suffering from cystic fibrosis and nasal polyps were studied. Two patients presented with nasal polyps at two years of age; the remaining patients had an initial polypectomy at any age up to fifteen years (mean age of seven and a half years). There were no obvious correlations between the cultures of the sinus washouts and the corresponding sputum samples. Organisms were only grown from five of the fifteen wash outs and from nine of the sputum samples. The patients with severe polyposis were not obviously more atopic.

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