An Artifact-Centric Approach to Dynamic Modification of Workflow Execution

2011 ◽  
pp. 256-273 ◽  
Author(s):  
Wei Xu ◽  
Jianwen Su ◽  
Zhimin Yan ◽  
Jian Yang ◽  
Liang Zhang
Keyword(s):  
Workflow Execution ◽  
Dynamic Modification

scholarly journals Regulating the Regulators: Mechanisms of Substrate Selection of the O-GlcNAc Cycling Enzymes OGT and OGA

Glycobiology ◽  
2021 ◽  
Author(s):  
Hannah M Stephen ◽  
Trevor M Adams ◽  
Lance Wells
Keyword(s):  
Nutrient Sensing ◽  
Substrate Selection ◽  
Disease States ◽  
Dynamic Modification ◽  
Selection For ◽  
Outstanding Question ◽  
Glcnac Transferase ◽  
Future Work ◽  
Partner Proteins ◽  
Selection Of

Abstract Thousands of nuclear and cytosolic proteins are modified with a single β-N-acetylglucosamine on serine and threonine residues in mammals, a modification termed O-GlcNAc. This modification is essential for normal development and plays important roles in virtually all intracellular processes. Additionally, O-GlcNAc is involved in many disease states, including cancer, diabetes, and X-linked intellectual disability. Given the myriad of functions of the O-GlcNAc modification, it is therefore somewhat surprising that O-GlcNAc cycling is mediated by only two enzymes: the O-GlcNAc transferase (OGT), which adds O-GlcNAc, and the O-GlcNAcase (OGA), which removes it. A significant outstanding question in the O-GlcNAc field is how do only two enzymes mediate such an abundant and dynamic modification. In this review, we explore the current understanding of mechanisms for substrate selection for the O-GlcNAc cycling enzymes. These mechanisms include direct substrate interaction with specific domains of OGT or OGA, selection of interactors via partner proteins, posttranslational modification of OGT or OGA, nutrient sensing, and localization alteration. Altogether, current research paints a picture of an exquisitely regulated and complex system by which OGT and OGA select substrates. We also make recommendations for future work, toward the goal of identifying interaction mechanisms for specific substrates that may be able to be exploited for various research and medical treatment goals.

scholarly journals A framework for risk assessment based on analysis of historical information of workflow execution in IT systems

2011 ◽  
Vol 55 (13) ◽  
pp. 2954-2975 ◽  
Author(s):  
Juliano Araujo Wickboldt ◽  
Luís Armando Bianchin ◽  
Roben Castagna Lunardi ◽  
Lisandro Zambenedetti Granville ◽  
Luciano Paschoal Gaspary ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Historical Information ◽  
Workflow Execution ◽  
It Systems

Structural Modification Simulation: Sensitivity Analysis and the Reanalysis of Modified Structure

1991 ◽  
Author(s):  
Debao Li ◽  
Fangze Li ◽  
Peiming Xu
Keyword(s):  
Sensitivity Analysis ◽  
Transfer Function ◽  
Coordinate Transformation ◽  
Degrees Of Freedom ◽  
Structural Modification ◽  
Function Analysis ◽  
Dump Truck ◽  
Analysis Method ◽  
Transfer Function Analysis ◽  
Dynamic Modification

Abstract This paper deals with the dynamic modification simulation of the structure. The expressions of sensitivity analysis of the system with non-proportional damping and proportional damping are derived at first. As for the reanalysis of modified structure, here we deal with the system to which the modification do not cause any change of the degrees of freedom. Transfer function analysis method and the method of twice coordinate transformation are expounded. As a successful example, the modification simulation of the frame of a dump truck is explained.

Enhancing mobile workflow execution by modeling flexible security controls

2017 ◽  
Author(s):  
Augusto Morales ◽  
Jose-Ignacio Castillo-Velazquez ◽  
Borja Bordel ◽  
Miguel Hernandez
Keyword(s):  
Workflow Execution ◽  
Security Controls
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