Immunocytochemical Demonstration of Renin and Converting Enzyme in Rat and Mouse Brain

1982 ◽  
pp. 126-136 ◽  
Author(s):  
E. Rix ◽  
D. Ganten ◽  
G. Stock ◽  
R. Taugner
Keyword(s):  
Mouse Brain ◽  
Converting Enzyme

Author response for "Comprehensive Topographical Map of the Serotonergic Fibers in the Male Mouse Brain"

2020 ◽  
Author(s):  
Janak R. Awasthi ◽  
Kota Tamada ◽  
Eric T. N. Overton ◽  
Toru Takumi
Keyword(s):  
Mouse Brain ◽  
Male Mouse ◽  
Author Response ◽  
Topographical Map

Author response for "Hemovasculogenic origin of blood vessels in the developing mouse brain"

2020 ◽  
Author(s):  
Miguel A. Gama Sosa ◽  
Rita De Gasperi ◽  
Gissel M. Perez ◽  
Patrick R. Hof ◽  
Gregory A. Elder
Keyword(s):  
Blood Vessels ◽  
Mouse Brain ◽  
Author Response ◽  
Developing Mouse Brain

Substrate specificity and inducibility of TACE (tumour necrosis factor α-converting enzyme) revisited: the Ala-Val preference, and induced intrinsic activity

2003 ◽  
Vol 70 ◽  
pp. 39-52 ◽  
Author(s):  
Roy A. Black ◽  
John R. Doedens ◽  
Rajeev Mahimkar ◽  
Richard Johnson ◽  
Lin Guo ◽  
...  
Keyword(s):  
Substrate Specificity ◽  
Recent Work ◽  
Tumour Necrosis Factor ◽  
Tumour Necrosis ◽  
Transforming Growth Factor ◽  
Intrinsic Activity ◽  
Converting Enzyme ◽  
Tumour Necrosis Factor Α ◽  
Factor Α ◽  
Necrosis Factor

Tumour necrosis factor α (TNFα)-converting enzyme (TACE/ADAM-17, where ADAM stands for a disintegrin and metalloproteinase) releases from the cell surface the extracellular domains of TNF and several other proteins. Previous studies have found that, while purified TACE preferentially cleaves peptides representing the processing sites in TNF and transforming growth factor α, the cellular enzyme nonetheless also sheds proteins with divergent cleavage sites very efficiently. More recent work, identifying the cleavage site in the p75 TNF receptor, quantifying the susceptibility of additional peptides to cleavage by TACE and identifying additional protein substrates, underlines the complexity of TACE-substrate interactions. In addition to substrate specificity, the mechanism underlying the increased rate of shedding caused by agents that activate cells remains poorly understood. Recent work in this area, utilizing a peptide substrate as a probe for cellular TACE activity, indicates that the intrinsic activity of the enzyme is somehow increased.

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