Although vaccines are successfully developed against Severe Acute Respiratory Syndrome Coronavirus-19 (COVID-19), and many anticancer, anti-malarial, antibiotic drugs have been repurposed against the disease, it has been just impossible to save valuable human lives in specific conditions. Therefore, medical care has been developed against COVID-19 but not fully able to save human life from the disease. As a result, the third wave is noticed in many countries. Preventive methods such as social distancing, wearing masks, and hand salinization have been accepted as the main strategies to break the chain of the disease. Due to the reduction in pollution under less or no industrial and vehicular operations, water and air ecosystems have been restored in an unseen manner. Especially, NO<sub>2</sub>, SO<sub>2</sub> and particulate matters etc. modulated higher expression of angiotensin-converting enzyme 2, the receptor of Severe Acute Respiratory Syndrome Coronavirus -2 in humans have also been emphatically documented. Therefore, along with medical care, environmental protection (especially to regulate NO<sub>2</sub> emissions) along with practicing COVID-19 guidelines is to be maintained fully to combat COVID-19 the disease. Human beings must use this knowledge and experience as a spotlight to save nature in current and future times.