Expression and function of the cardiac Na+/Ca2+ exchanger in postnatal development of the rat, in experimental-induced cardiac hypertrophy, and in the failing human heart

1998 ◽  
pp. 77-84
Author(s):  
Roland Studer ◽  
H. Reinecke ◽  
R. Vetter ◽  
J. Holtz ◽  
H. Drexler
Keyword(s):  
Cardiac Hypertrophy ◽  
Postnatal Development ◽  
Human Heart ◽  
And Function

scholarly journals Dill Extract Induces Elastic Fiber Neosynthesis and Functional Improvement in the Ascending Aorta of Aged Mice with Reversal of Age-Dependent Cardiac Hypertrophy and Involvement of Lysyl Oxidase-Like-1

Biomolecules ◽  
2020 ◽  
Vol 10 (2) ◽  
pp. 173 ◽  
Author(s):  
Wassim Fhayli ◽  
Quentin Boëté ◽  
Nadjib Kihal ◽  
Valérie Cenizo ◽  
Pascal Sommer ◽  
...  
Keyword(s):  
Cardiac Hypertrophy ◽  
Lysyl Oxidase ◽  
Elastic Fiber ◽  
Ascending Aorta ◽  
Functional Improvement ◽  
Elastic Fibers ◽  
Aged Mice ◽  
Age Related ◽  
And Function

Elastic fibers (90% elastin, 10% fibrillin-rich microfibrils) are synthesized only in early life and adolescence mainly by the vascular smooth muscle cells through the cross-linking of its soluble precursor, tropoelastin. Elastic fibers endow the large elastic arteries with resilience and elasticity. Normal vascular aging is associated with arterial remodeling and stiffening, especially due to the end of production and degradation of elastic fibers, leading to altered cardiovascular function. Several pharmacological treatments stimulate the production of elastin and elastic fibers. In particular, dill extract (DE) has been demonstrated to stimulate elastin production in vitro in dermal equivalent models and in skin fibroblasts to increase lysyl oxidase–like-1 (LOXL-1) gene expression, an enzyme contributing to tropoelastin crosslinking and elastin formation. Here, we have investigated the effects of a chronic treatment (three months) of aged male mice with DE (5% or 10% v/v, in drinking water) on the structure and function of the ascending aorta. DE treatment, especially at 10%, of aged mice protected pre-existing elastic lamellae, reactivated tropoelastin and LOXL-1 expressions, induced elastic fiber neo-synthesis, and decreased the stiffness of the aging aortic wall, probably explaining the reversal of the age-related cardiac hypertrophy also observed following the treatment. DE could thus be considered as an anti-aging product for the cardiovascular system.

scholarly journals S ‐glutathiolation impairs phosphoregulation and function of cardiac myosin‐binding protein C in human heart failure

2016 ◽  
Vol 30 (5) ◽  
pp. 1849-1864 ◽  
Author(s):  
Konstantina Stathopoulou ◽  
Ilka Wittig ◽  
Juliana Heidler ◽  
Angelika Piasecki ◽  
Florian Richter ◽  
...  
Keyword(s):  
Heart Failure ◽  
Protein C ◽  
Human Heart ◽  
Binding Protein ◽  
Cardiac Myosin ◽  
Human Heart Failure ◽  
Myosin Binding Protein ◽  
Myosin Binding Protein C ◽  
Myosin Binding ◽  
And Function

scholarly journals Disproportionate cardiac hypertrophy during early postnatal development in infants born preterm

2017 ◽  
Vol 82 (1) ◽  
pp. 36-46 ◽  
Author(s):  
Christina Y L Aye ◽  
Adam J Lewandowski ◽  
Pablo Lamata ◽  
Ross Upton ◽  
Esther Davis ◽  
...  
Keyword(s):  
Cardiac Hypertrophy ◽  
Postnatal Development ◽  
Early Postnatal Development

scholarly journals Modeling the heart with Novoheart’s MyHeart™ platform

2020 ◽  
Vol 2 (2) ◽  
pp. FDD32
Author(s):  
Gabriel K Y Wong ◽  
Kevin D Costa ◽  
Bernard Fermini ◽  
Ronald A Li
Keyword(s):  
Human Heart ◽  
Animal Testing ◽  
Cardiac Tissues ◽  
Drug Discovery And Development ◽  
Human Cardiomyocytes ◽  
Effective Models ◽  
And Function ◽  
2D And 3D ◽  
Human Specific

Reliable and predictive human-specific in vitro heart models can revolutionize drug discovery and development. With the advent of pluripotent stem cell technologies, human cardiomyocytes can now be readily produced in large quantities. Using tissue engineering techniques, they can be further assembled into cardiac tissues of specific 2D and 3D configurations, to create models that behave and function like the native human heart. Novoheart (BC, Canada) uniquely offers the MyHeartTM Platform of bioengineered human heart constructs, designed to provide researchers with effective models of either healthy or diseased human hearts. As in vitro, human-based assays become more widely accepted, the next decade could witness a shift away from animal testing towards more accurate and scalable human assays like the MyHeartTM Platform.

Ca2+-ATPase and function of sarcoplasmic reticulum during cardiac hypertrophy

1991 ◽  
Vol 261 (4) ◽  
pp. L23-L26 ◽  
Author(s):  
Dmitri Levitsky ◽  
Diane De La Bastie ◽  
Ketty Schwartz ◽  
Anne-Marie Lompré
Keyword(s):  
Sarcoplasmic Reticulum ◽  
Cardiac Hypertrophy ◽  
Calcium Ion ◽  
Adenosine Triphosphatase ◽  
State Level ◽  
Calcium Sensitivity ◽  
Left Ventricular ◽  
Pump System ◽  
Messenger Ribonucleic Acid ◽  
And Function

The properties of the calcium pump system of sarcoplasmic reticulum (SR) were studied in a series of 34 rats subjected to cardiac overload and 19 sham-operated animals. Total homogenates of left ventricle were analyzed by measuring the oxalate-supported Ca2+ uptake rate, the steady-state level of the phosphorylated intermediate of Ca2+-adenosine triphosphatase (Ca2+-ATPase) (E-P), and the amount of Ca2+-ATPase mRNA. All three parameters decreased gradually as a function of the relative left ventricular weight increase. The calcium-sensitivity curves showed that the velocity of Ca2+ transport in SR from the hypertrophied heart is diminished at low as well as optimal Ca2+2 concentrations, with the dissociation constant (Kd) value for Ca2+ unchanged from that of the control preparation. Taken together with the results presented in our recent publication (De la Bastie, Levitsky, Mercadier, Marotte, Wisnewsky, Brovkovivh, Schwartz, and Lompré, Circ. Res. 66: 554–564, 1990), these data strongly indicate that differences in the Ca2+ pump activities of SR from normal and hypertrophied rat hearts are due to quantitative rather than qualitative changes of the Ca2+-ATPase protein. calcium ion uptake; calcium ion adenosine triphosphatase messenger ribonucleic acid; cardiac hypertrophy; monoclonal antibody

Energetics and function of the failing human heart with dilated or hypertrophic cardiomyopathy

1999 ◽  
Vol 29 (6) ◽  
pp. 469-477 ◽  
Author(s):  
K. K. Kalsi ◽  
R. T. Smolenski ◽  
R. D. Pritchard ◽  
A. Khaghani ◽  
A-M. L. Seymour ◽  
...  
Keyword(s):  
Hypertrophic Cardiomyopathy ◽  
Human Heart ◽  
And Function
Sign in / Sign up

Export Citation Format

Share Document