Carcinoma of Unknown Primary-(CUP)-Syndrom — Rationelle Diagnostik mit der 18Fluorodeoxyglukose-Positronenemissionstomografie / Clinical Value of 18Fluorodeoxyglucose Positron Emission Tomography in Carcinoma of Unknown Primary

Author(s):  
M. Wenzke ◽  
St. Leinung ◽  
P. Würl ◽  
M. Schönfelder
Head & Neck ◽  
2010 ◽  
Vol 33 (11) ◽  
pp. 1569-1575 ◽  
Author(s):  
Florian Keller ◽  
Georgios Psychogios ◽  
Rainer Linke ◽  
Michael Lell ◽  
Torsten Kuwert ◽  
...  

Author(s):  
Meenu Induchoodan ◽  
Rajeev Kumar Madhavan ◽  
Shibu George

<p class="abstract">Carcinoma of unknown primary (CUP) represents a heterogeneous group of malignancy metastasis unique biology of which remains poorly understood. Even after a complete diagnostic workup including positron emission tomography and computerised tomography (PET-CT) scans the primary site of origin may remain unclear. This case series analysed the diagnostic value of bilateral palatine tonsillectomy in evaluating PET-CT negative head and neck squamous cell CUP. From retrospective analysis of cluster of 68 cases with metastatic cervical nodes with no obvious primary referred for ENT evaluation during a period of 20 months, we identified 5 cases where pan endoscopy and radiological evaluation including PET-CT were negative in detecting the primary. All 5 patients underwent bilateral palatine tonsillectomy along with biopsies from base of tongue and nasopharynx as a part of completion of diagnostic work-up. Tonsillar squamous cell carcinoma was revealed by subsequent histopathology examination in 4 out of 5 patients despite negative PET-CT evaluation. Blind biopsies from other sites like nasopharynx and base of tongue were unfruitful. Our experience strongly emphasises the fact that bilateral palatine tonsillectomy has a high yield in detecting primary even in PET negative CUP, though it needs a larger evidence base.</p>


Cancer ◽  
2007 ◽  
Vol 109 (2) ◽  
pp. 292-299 ◽  
Author(s):  
Pascal Sève ◽  
Claire Billotey ◽  
Christiane Broussolle ◽  
Charles Dumontet ◽  
John R. Mackey

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