A Case of Metastatic CNS Melanoma of Unknown Primary Presenting with Seizures

Seizures are a common occurrence. The goal of evaluating a seizure is to identify the etiology and to determine the likelihood of recurrence as well as guide management. We present a unique presentation of a 47-year-old female that presented with late onset seizures admitted due to status epilepticus. Brain magnetic resonance indicated diffuse supratentorial hemorrhagic lesions. Neurological workup including brain vessel imaging, CT chest, abdomen, and pelvis as well as CSF and serological workup for vasculitis failed to demonstrate the cause of her brain lesions. Ultimately, a brain biopsy showed metastatic melanoma of unknown primary origin.

Eurythrematosis as a developmental model of the Diabetes Mellitus type 1 pathological condition: pathophysiological parameters and oxidative stress / Eurytrematose como modelo de desenvolvimento da patologia da Diabetes Mellitus tipo 1: parâmetros fisiopatológicos e stress oxidativo

Eurytrematosis is a helminthic disease caused by trematodes belonging to the genus Eurytrema spp. that parasitize the pancreas of many animals and humans. This parasitosis causes chronic fibrosing pancreatitis, fat infiltration in the pancreatic parenchyma, besides damaging the exocrine pancreas, which is similar to that found in patients with Diabetes Mellitus type 1 (DM1). The current work aimed to evaluate the use of bovine pancreas infected with E. coelomaticum as a model to study DM1 pathophysiology. It was carried out macroscopic analyses, parasite identification, total pancreatic lipid determination and oxidative damage biomarkers levels of pancreas naturally infected with E. coelomaticum. Macroscopically, we observed that the infected pancreas had duct obstruction, organ stiffness due to the visible presence of fibrosis, increased adipose tissue deposition, increased protein and lipid damage, as well as increased antioxidant biomarkers (GSH, CAT and VIT C). Thus, it is possible to show that DM1 may have pancreatic parasitism as a possible primary origin. However, more studies are needed to better investigate this possible primary origin; the results obtained here suggest that the use of pancreas parasitized by E. coelomaticum could be a model to investigate DM1 pathophysiology.

Presumed Melanoma of Unknown Primary Origin Metastatic to the Choroid Mimics Primary Uveal Melanoma

We describe the case of a 69-year-old woman who presented with a decline in vision in the left eye and was found to have a choroidal lesion with clinical and echographic features concerning for primary uveal melanoma. Systemic imaging identified numerous metastases to the liver, kidneys, paratracheal lymph nodes, lung, and brain. The hepatic lesion was biopsied, and genetic analysis identified a Val600Glu (c.1799T&#x3e;A) <i>BRAF</i> mutation, consistent with a cutaneous primary malignancy, although no primary tumor was identified. This case highlights that metastasis to the choroid is a rare presentation of nonuveal melanoma that can mimic primary uveal melanoma. Genetic analysis of tumor tissue can identify the origin of the melanoma and guide treatment options. Systemic imaging should be performed prior to intervention for choroidal neoplasms.

The Role of Human Rights and Obligations toward Cross Gender Empowerment under the domain of Islamic Laws

This study enumerates Islamic laws regarding women rights throughout the extent of Quran and Hadith in the principal origins of Islam. It highlights toward gender equity and women rights. Islamic principles consistently accord with nature of man and woman and think about their intrinsic contrasts. Islam has ensured people (both men and women) human rights and obligations associated with them as people in an equivalent degree. What Islam ensures usually not get conveyed into solid actions because of dominant communal and ethnic standards and in context of social and cultural relations. The basic estimations of Islam ostensibly advance and respect the status of women in the public eye. Islam gave freedom to Muslim women by allowing them equivalent rights as similar to their male partners, as demonstrated by the Prophet Mohammad ??? ???? ???? ???? (PHUH) [women are identical parts orsisters in relation to men]. Numerous adamant translations of Islamic messages and practices of a larger number of Muslim societies unfortunately disagree the primary origin of women rights as well as gender equalities. Besides, it is falsly realized that Muslim females particularly are in retrograte position and are also mistreated by religion Islam as compare to non-Muslim women who are observed as liberated, modernized and forward. Thusly, this article focuses to distinguish how religion Islam has provided women their rights, liberty, equality and respect.

A Case Report of Inflammatory Myofibroblastic Tumor of the Sphenoidal Sinus

Inflammatory myofibroblastic tumor (IMT) is a tumor composed of differentiated myofibroblastic spindle-shaped cells. It occurs in the soft tissues of the abdomen and lungs, and is very rare in the sphenoid sinus. The diagnosis depends on histopathology and immunohistochemistry, and is easily misdiagnosed. Although metastasis is rare, the recurrence rate is high. Surgical resection is the treatment of choice, and where complete resection is difficult, radiation therapy, hormonal therapy, or molecular targeted drug therapy can be administered. We report a rare case of IMT with a primary origin in the sphenoid sinus, which was entirely resected by nasal endoscopy and confirmed by histological examination.

Cancer of unknown primary origin presented with rapid deterioration without significant symptoms, a case report

A 34-year-old woman with flank pain was referred for suspicious lymphadenopathy. PET/CT scan revealed disseminated lesions without apparent primary origin. Although she did not complain of any symptoms, after rapid deterioration, she died of respiratory distress and cardiac arrest. Her strong beliefs contribute to symptoms tolerance and late diagnosis.

The Role of Immunohistochemistry in the Workup of Malignant Neoplasms of Unknown Primary Origin at Khartoum Oncology Hospital

Background: Carcinoma of unknown primary origin (CUP) comprises various malignancies classified by detection of tissue-specific genes through immunohistochemistry (IHC). We aimed to explore the role of available immunohistochemical markers in diagnosing and classifying malignant neoplasms of unknown primary origin.Methods: A cross-sectional study included 141 patients diagnosed histologically as CUP and referred to the Histopathology and Immunohistochemistry Department, Khartoum Oncology Hospital, from 2012 to 2017. Hematoxylin and Eosin (H&E) and immune stained slides used in the workup were reviewed and classified into the main histologic types of CUP. Data were -analyzed by SPSS. Results: Out of 4436 cases, CUP represents (3.2%). The age group (60-69) years have the highest percentage (20.13%), with male predominance (51.77%). Lymph nodes represent (41.84%) followed by the liver (12.77%), spine (3.55%), and lungs (2.13%). Adenocarcinoma (75.89%) was the most common subtype, followed by undifferentiated neoplasm (14.18%), squamous cell carcinoma (7.09%), and carcinoma with neuroendocrine differentiation (2.84%). In 70 cases (49.6%) of the study cases, the primary site was determined, (17.7%) were given an only differential diagnosis, and in (32.6%) the origin remains unknown. Conclusions: CUP cases during the study period are infrequent (3.2%), and the primary origin was determined in nearly half of patients by the available immune markers. CUP’s common histological types were adenocarcinoma, undifferentiated neoplasm, squamous cell carcinoma, and carcinoma with neuroendocrine differentiation. The most common presenting sites were lymph node, liver, spine, and lungs.

End Effect Analysis of a Slot-Less Long-Stator Permanent Magnet Linear Synchronous Motor

The implications of the end effect for flux linkage and thrust ripple in a slot-less long-stator permanent magnet linear synchronous motor (LSPMLSM), are analyzed in this paper. Since it is affected by the end effect, the air-gap magnetic field density under the end permanent magnet is different from that under the non-end permanent magnet, leading to asymmetry in the thrust ripple. For this reason, we establish a dynamic permanent magnet flux linkage model, which proves that the end effect leads to sub-harmonics in the permanent magnet flux linkage. The motor’s magnetic field distribution in the left and right parts is symmetrical. A thrust model taking into account the flux linkage sub-harmonics is established, from which the amplitude and period of the thrust ripple caused by the end effect can be calculated. There is no detent force for the slot-less LSPMLSM, and the end effect is the primary origin of the motor thrust ripple. In order to suppress the end effect, a method of increasing the end iron length is proposed, as a result of which the sub-harmonics in the flux linkage and the motor thrust ripple are effectively suppressed. Experimental and simulation results verify the results of this paper.