Effects of Metformin on Glycaemic Control and Cardiovascular Risk in Type 2 Diabetes

Author(s):  
G. Perriello
2014 ◽  
Vol 10 ◽  
pp. P907-P908 ◽  
Author(s):  
Jolien Janssen ◽  
Esther van den Berg ◽  
Michaela Mattheus ◽  
Odd Erik Johansen ◽  
Geert Jan Biessels

2003 ◽  
Vol 60 (3) ◽  
pp. 161-169 ◽  
Author(s):  
Giuseppe Derosa ◽  
Amedeo Mugellini ◽  
Leonardina Ciccarelli ◽  
Giuseppe Crescenzi ◽  
Roberto Fogari

1998 ◽  
Vol 15 (4) ◽  
pp. 304-307 ◽  
Author(s):  
G. Bruno ◽  
P. Cavallo-Perin ◽  
G. Bargero ◽  
M. Borra ◽  
N. D’Errico ◽  
...  

2018 ◽  
Vol 21 (5) ◽  
pp. 399-403 ◽  
Author(s):  
Eberhard Standl

Heart failure (HF) is one of the most common comorbidities of type 2 diabetes mellitus (T2DM) and poor glycaemic control can worsen the HF outcomes and increase the risk of hospitalisations. With the entry of several antihyperglycaemic agents for the management of T2DM over the last decade, there has been an increasing concern regarding the cardiovascular (CV) safety profile of these agents. In view of this, FDA mandated the demonstration of cardiovascular risk-benefit profile of these agents through specifically designed CV outcome trials. Although we have several findings from these trials, none of them included HF as a primary endpoint indicating the need of trials focusing on HF. Here, we briefly discuss the results of the CV outcome trials in the context of HF.


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