The Role of the Immunophilin FKBP12 in Cerebral Ischemia

2001 ◽  
pp. 61-69
Author(s):  
H. Kato ◽  
K. Otsuka ◽  
T. Araki ◽  
T. Oikawa ◽  
A. Takahashi ◽  
...  
Keyword(s):  
Cerebral Ischemia

Central role of neuronal IkappaBalpha kinase (IKK) in cerebral ischemia

2005 ◽  
Vol 25 (1_suppl) ◽  
pp. S458-S458
Author(s):  
Oliver Herrmann ◽  
Rossanna de Lorenzi ◽  
Sajjad Muhammad ◽  
Wen Zhang ◽  
Martin Koehrmann ◽  
...  
Keyword(s):  
Cerebral Ischemia

The Role of Melatonin in Multiple Sclerosis, Huntington's Disease and Cerebral Ischemia

2014 ◽  
Vol 13 (6) ◽  
pp. 1096-1119 ◽  
Author(s):  
Begona Escribano ◽  
Ana Colin-Gonzalez ◽  
Abel Santamaria ◽  
Isaac Tunez
Keyword(s):  
Multiple Sclerosis ◽  
Cerebral Ischemia ◽  
Huntington's Disease ◽  
Huntington’S Disease

scholarly journals PET Imaging with [18F]FSPG Evidences the Role of System xc- on Brain Inflammation Following Cerebral Ischemia in Rats

Theranostics ◽  
2016 ◽  
Vol 6 (11) ◽  
pp. 1753-1767 ◽  
Author(s):  
Maria Domercq ◽  
Boguslaw Szczupak ◽  
Jon Gejo ◽  
Vanessa Gómez-Vallejo ◽  
Daniel Padro ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Pet Imaging ◽  
Brain Inflammation

scholarly journals Differential role of SIRT1/MAPK pathway during cerebral ischemia in rats and humans

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Sireesh Kumar Teertam ◽  
Phanithi Prakash Babu
Keyword(s):  
Cerebral Ischemia ◽  
Caspase 3 ◽  
Mapk Pathway ◽  
Protective Role ◽  
Akt Signaling ◽  
Sirtuin 1 ◽  
Neurological Dysfunction ◽  
Dependent Manner ◽  
Erk Mapk

AbstractCerebral ischemia (CI) is a severe cause of neurological dysfunction and mortality. Sirtuin-1 (Silent information regulator family protein 1, SIRT1), an oxidized nicotinamide adenine dinucleotide (NAD+)-dependent protein deacetylase, plays an important role in protection against several neurodegenerative disorders. The present study aims to investigate the protective role of SIRT1 after CI in experimental young and aged rats and humans. Also, the study examines the possible regulatory mechanisms of neuronal death in CI settings. Immunoblotting and immunohistochemistry were used to evaluate changes in the expression of SIRT1, JNK/ERK/MAPK/AKT signaling, and pro-apoptotic caspase-3 in experimental rats and CI patients. The study findings demonstrated that, in aged experimental rats, SIRT1 activation positively influenced JNK and ERK phosphorylation and modulated neuronal survival in AKT-dependent manner. Further, the protection conferred by SIRT1 was effectively reversed by JNK inhibition and increased pro-apoptotic caspase-3 expression. In young experimental rats, SIRT1 activation decreased the phosphorylation of stress-induced JNK, ERK, caspase-3, and increased the phosphorylation of AKT after CI. Inhibition of SIRT1 reversed the protective effect of resveratrol. More importantly, in human patients, SIRT1 expression, phosphorylation of JNK/ERK/MAPK/AKT signaling and caspase-3 were up-regulated. In conclusion, SIRT1 could possibly be involved in the modulation of JNK/ERK/MAPK/AKT signaling pathway in experimental rats and humans after CI.

scholarly journals Key Role of CD36 in Toll-Like Receptor 2 Signaling in Cerebral Ischemia

Stroke ◽  
2010 ◽  
Vol 41 (5) ◽  
pp. 898-904 ◽  
Author(s):  
Takato Abe ◽  
Munehisa Shimamura ◽  
Katherine Jackman ◽  
Hitomi Kurinami ◽  
Josef Anrather ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Toll Like Receptor ◽  
Toll Like Receptor 2

scholarly journals The regulatory role of NF-κB in autophagy-like cell death after focal cerebral ischemia in mice

Neuroscience ◽  
2013 ◽  
Vol 244 ◽  
pp. 16-30 ◽  
Author(s):  
W.-L. Li ◽  
S.P. Yu ◽  
D. Chen ◽  
S.S. Yu ◽  
Y.-J. Jiang ◽  
...  
Keyword(s):  
Cell Death ◽  
Cerebral Ischemia ◽  
Focal Cerebral Ischemia ◽  
Regulatory Role

scholarly journals Role of Histamine and Its Receptors in Cerebral Ischemia

2012 ◽  
Vol 3 (4) ◽  
pp. 238-247 ◽  
Author(s):  
Wei-Wei Hu ◽  
Zhong Chen
Keyword(s):  
Cerebral Ischemia
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