Inflammatory Diseases of the Lacrimal Gland

2000 ◽  
pp. 95-107
Author(s):  
Renate Unsöld ◽  
Gabriele Greeven
Keyword(s):  
Lacrimal Gland ◽  
Inflammatory Diseases

P53 Paediatric non-infectious dacryoadenitis: a single-centre experience

Rheumatology ◽  
2019 ◽  
Vol 58 (Supplement_4) ◽  
Author(s):  
Joana Silva-Dinis ◽  
Ameenat Lola Solebo ◽  
Yassir Abou-Rayyah ◽  
Sandrine Compeyrot-Lacassagne
Keyword(s):  
Lacrimal Gland ◽  
Conflicts Of Interest ◽  
Inflammatory Diseases ◽  
Response To Treatment ◽  
Initial Manifestation ◽  
Single Centre Experience ◽  
Paediatric Cohort ◽  
Systemic Condition ◽  
Sjögren’S Disease

Abstract Background Dacryoadenitis is an inflammatory enlargement of the lacrimal gland and can be idiopathic or associated with infections, malignant or inflammatory diseases like Sjögren’s disease (SSj) or granulomatosis with polyangiitis (GPA). It remains the most common orbital inflammatory condition in children. This study purposes to describe a paediatric cohort of non-infectious dacryoadenitis. Methods Identification of children who underwent lacrimal gland biopsy at our centre between 2000 and 2018 was done by searching the database using two key-words: “lacrimal” and “dacryoadenitis”. Patients with infectious or malignant dacryoadenitis were excluded. Medical notes were reviewed to collect data. Results Twenty-six patients underwent lacrimal gland biopsy at our centre between 2000 and 2018 and had inflammatory dacryoadenitis. 17 patients (65.4%) had non-specific chronic inflammation (NSCI) and 9 patients (34.6%) had an inflammatory systemic condition (Table 1). P53 Table 1Patients’ characteristics.NSCIGPASarcoidosisSSjogrenIgG4Number of patients17 (65.4%)4 (15.4%)3 (11.5%)1 (3.9%)1 (3.9%)Female, n (%)6 (35.3%)4 (100%)3 (100%)1 (100%)1 (100%)Median age (Y) (IQ)10.5 (4.9- 14.4)9.72 (8.7- 13.0)13.2 (11.45- 15.7)11.911.2Lacrimal gland involvementUnilateral13 (74.5%)3 (75.0%)2 (66.7%)00Bilateral4 (23.5%)1 (25.0%)1 (33.3%)1 (100%)1 (100%)Orbital symptomsPtosis4 (23.5%)1 (25.0%)000Erythema3 (17.5%)1 (25.0%)1 (33.3%)00Pain2 (11.8%)1 (25.0%)000Extra-orbital involvementExocrine glands001 (33.3%)00ENT03 (75.0%)000Renal1 (14.3%)2 (50.0%)01 (100%)1 (100%)Pulmonary1 (14.3%)1 (25.0%)1 (33.3%)01 (100%)Myositis1 (14.3%)0000Arthralgia1 (14.3%)01 (33.3%)00Thyroiditis1 (14.3%)0000CNS0001 (100%)0Lymphadenopaties00001 (100%) 4/13 children tested had raised ACE (2 sarcoidosis and 2 NSCI). 7/17 had raised amylase (2 sarcoidosis,1 SSj, 4 NSCI). 3/16 had raised IgG (IgG4 disease, GPA and NSCI). ANA was positive in 4/19 patients (NSCI, GPA, Sarcoidose, SSj) and ANCA was positive in 4/19 patients (GPA). Thirteen patients received steroids (oral or IV) and elevan received DMARDS (MMF, methotrexate, azathioprine and hydroxychloroquine). Four patients received biologic (rituximab, adalimumab or infliximab). Six patients underwent orbitotomy. Patients still on follow-up had good response to treatment. One patient with NSCI presented with dacryoadenitis and later developed auto-immune thyroiditis and polymyositis, with positive ANA and anti-SRP antibodies. He was treated with steroids, methotrexate, MMF and IVIG. Conclusion Paediatric rheumatic inflammatory disorders have a diverse presentation and dacryoadenitis may be the initial manifestation. Biopsy is mandatory to exclude infection and malignancy. A full diagnostic workup is essential, especially if patients have positive ANA or ANCA. Conflicts of Interest The authors declare no conflicts of interest.

Complications of Inflammatory Diseases of the Sinuses

1993 ◽  
Vol 26 (4) ◽  
pp. 639-655 ◽  
Author(s):  
James A. Stankiewicz ◽  
David J. Newell ◽  
Albert H. Park
Keyword(s):  
Inflammatory Diseases

Nutritional modification of inflammatory diseases

1997 ◽  
Vol 12 (3) ◽  
pp. 212-222 ◽  
Author(s):  
W.D. Schoenherr ◽  
Dennis E. Jewell
Keyword(s):  
Inflammatory Diseases

Clinical applications of single photon emission tomography in neuromedicine

2000 ◽  
Vol 39 (08) ◽  
pp. 218-231 ◽  
Author(s):  
F. Grünwald ◽  
T. Kuwert ◽  
K. Tatsch ◽  
O. Sabri ◽  
O. Benkert ◽  
...  
Keyword(s):  
Single Photon ◽  
Inflammatory Diseases ◽  
Photon Emission ◽  
Clinical Applications ◽  
Emission Tomography ◽  
Receptor Ligands ◽  
Single Photon Emission ◽  
The Central Nervous System ◽  
Dementing Disorders ◽  
Photon Emission Tomography

SummaryThis article gives in his second part a critical review of the clinical applications of SPECT with perfusion markers and receptor ligands in dementing disorders and psychosis. In addition this review discusses clinical applications of SPECT investigations with perfusion markers in inflammatory diseases of the central nervous system and in brain trauma.

Heparin and proteoglycans as anti-inflammatory drugs

1996 ◽  
Vol 16 (01) ◽  
pp. 56-59
Author(s):  
D. J. Tyrrell ◽  
C. P. Page
Keyword(s):  
Inflammatory Diseases ◽  
Therapeutic Applications ◽  
Wide Range ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

SummaryEvidence continues to accumulate that the pleiotropic nature of heparin (beyond its anticoagulant potency) includes anti-inflammatory activities at a number of levels. It is clear that drugs exploiting these anti-inflammatory activities of heparin may offer exciting new therapeutic applications to the treatment of a wide range of inflammatory diseases.

Lacrimal Gland Cyst

2020 ◽  
Author(s):  
Keyword(s):  
Lacrimal Gland

PCR-based Investigation of Infection Patterns in Patients with Pelvic Inflammatory Diseases in Jeju

2013 ◽  
Vol 3 (2) ◽  
pp. 75 ◽  
Author(s):  
Woo Jin Kim ◽  
Kyutaeg Lee ◽  
Dong Lyul Kim
Keyword(s):  
Inflammatory Diseases
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