Negative Selection of Self-reactive B Lymphocytes Involves Complement

1999 ◽  
pp. 21-29 ◽  
Author(s):  
M. Carroll
Keyword(s):  
B Lymphocytes ◽  
Negative Selection ◽  
Selection Of

Positive and Negative Selection of Human B Lymphocytes in Vitro

1997 ◽  
Vol 815 (1 B-Lymphocytes) ◽  
pp. 237-245 ◽  
Author(s):  
JACQUES BANCHEREAU ◽  
LAURENT GALIBERT ◽  
CHRISTOPHE ARPIN ◽  
NICOLAS BURDIN ◽  
YONG-JUN LIU ◽  
...  
Keyword(s):  
B Lymphocytes ◽  
Negative Selection ◽  
Selection Of

Negative selection of B lymphocytes: a novel role for innate immunity

2000 ◽  
Vol 173 (1) ◽  
pp. 120-130 ◽  
Author(s):  
Jennifer L. Gommerman ◽  
Michael C. Carroll
Keyword(s):  
Innate Immunity ◽  
B Lymphocytes ◽  
Negative Selection ◽  
Selection Of

scholarly journals A Role for Fas in Negative Selection of Thymocytes In Vivo

1998 ◽  
Vol 187 (9) ◽  
pp. 1427-1438 ◽  
Author(s):  
Hidehiro Kishimoto ◽  
Charles D. Surh ◽  
Jonathan Sprent
Keyword(s):  
Negative Selection ◽  
Cell Receptor ◽  
Staphylococcal Enterotoxin B ◽  
Thymic Medulla ◽  
Enterotoxin B ◽  
High Doses ◽  
Specific Peptide ◽  
Selection Of

To seek information on the role of Fas in negative selection, we examined subsets of thymocytes from normal neonatal mice versus Fas-deficient lpr/lpr mice injected with graded doses of antigen. In normal mice, injection of 1–100 μg of staphylococcal enterotoxin B (SEB) induced clonal elimination of SEB-reactive Vβ8+ cells at the level of the semi-mature population of HSAhi CD4+ 8− cells found in the thymic medulla; deletion of CD4+ 8+ cells was minimal. SEB injection also caused marked elimination of Vβ8+ HSAhi CD4+ 8− thymocytes in lpr/lpr mice. Paradoxically, however, elimination of these cells in lpr/lpr mice was induced by low-to-moderate doses of SEB (≤1 μg) but not by high doses (100 μg). Similar findings applied when T cell receptor transgenic mice were injected with specific peptide. These findings suggest that clonal elimination of semi-mature medullary T cells is Fas independent at low doses of antigen but Fas dependent at high doses. Previous reports documenting that negative selection is not obviously impaired in lpr/lpr mice could thus reflect that the antigens studied were expressed at only a low level.

Epitope mapping by negative selection of randomized antigen libraries displayed on filamentous phage 1 1Edited by J. Karn

1997 ◽  
Vol 269 (5) ◽  
pp. 704-718 ◽  
Author(s):  
Laurent Jespers ◽  
Stéphane Jenné ◽  
Ignace Lasters ◽  
Désiré Collen
Keyword(s):  
Negative Selection ◽  
Epitope Mapping ◽  
Filamentous Phage ◽  
Selection Of

scholarly journals Positive and negative selection of antigen-specific B cells in transgenic mice expressing variant forms of the VH1 (T15) heavy chain

2000 ◽  
Vol 12 (6) ◽  
pp. 873-885 ◽  
Author(s):  
James J. Kenny ◽  
Eric G. Derby ◽  
Jeffrey A. Yoder ◽  
Shawn A. Hill ◽  
Randy T. Fischer ◽  
...  
Keyword(s):  
B Cells ◽  
Transgenic Mice ◽  
Heavy Chain ◽  
Negative Selection ◽  
Selection Of

An extended ToxR POSSYCCAT system for positive and negative selection of self-interacting transmembrane domains

2007 ◽  
Vol 69 (2) ◽  
pp. 298-305 ◽  
Author(s):  
Eric Lindner ◽  
Stephanie Unterreitmeier ◽  
Anja N.J.A. Ridder ◽  
Dieter Langosch
Keyword(s):  
Negative Selection ◽  
Transmembrane Domains ◽  
Selection Of
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