Control of DNA Polymerase Activity in Synchronized Growing Yeast after X-Irradiation

1976 ◽  
pp. 25-34
Author(s):  
H. Eckstein
Keyword(s):  
Dna Polymerase ◽  
Polymerase Activity ◽  
X Irradiation

scholarly journals X-ray Induced Activity of N-Ethylmaleimide-Sensitive DNA Polymerase in Chinese Hamster Cells

1980 ◽  
Vol 33 (4) ◽  
pp. 423 ◽  
Author(s):  
RG Ramsay ◽  
M Westerman
Keyword(s):  
Dna Polymerase ◽  
Chinese Hamster ◽  
Polymerase Activity ◽  
Low Doses ◽  
X Rays ◽  
Chinese Hamster Cells ◽  
X Ray ◽  
Long Period ◽  
Initial Rise ◽  
X Irradiation

Chinese hamster DDN cells have been exposed to low doses of X-irradiation � 15 Gy). These doses have been shown to induce significant levels of repair replication. Levels of activity of DNA polymerase were subsequently measured in cells exposed in G 1 phase of mitosis to 7�5 Gy of X-rays. Following exposure, the activity of this enzyme was observed to rise to a peak within 15 min postirradiation, then decline and then rise again over a long period. The initial rise at least was found to be sensitive to inhibition by N-ethylmaleimide, a known inhibitor of DNA polymerase-o< and DNA polymerase-y at the concentration used. It is therefore suggested that repair of X-ray-induced damage in these DON cells was at least in part dependent upon induced DNA polymerase activity and this may involve DNA polymerase-o< or DNA polymerase-y, or both.

Facile and Sensitive Fluorescence Assay of DNA Polymerase Activity Using Cu2+ and Ascorbate as Signal Developers

2019 ◽  
Vol 4 (8) ◽  
pp. 2398-2403 ◽  
Author(s):  
Xingxing Zhang ◽  
Qiang Liu ◽  
Yan Jin ◽  
Baoxin Li
Keyword(s):  
Dna Polymerase ◽  
Polymerase Activity ◽  
Fluorescence Assay

Suggestive Evidence for an Oncorna-Virus-Specific DNA Polymerase from C-Type Particles of Bovine Leukosis

1974 ◽  
Vol 29 (1-2) ◽  
pp. 72-75 ◽  
Author(s):  
B. Dietzschold ◽  
O.R. Kaaden ◽  
S. Ueberschaer ◽  
F. Weiland ◽  
O. C. Straub
Keyword(s):  
Dna Polymerase ◽  
Polymerase Activity ◽  
Friend Virus ◽  
Leukaemia Virus ◽  
Virus Particles ◽  
Virus Rna ◽  
Feline Leukaemia Virus ◽  
Bovine Leukosis ◽  
Bovine Lymphocytes ◽  
Viral Preparation

Abstract Typical C-type oncorna virus particles as shown by electron microscopy have been purified from the supernatant of cultured lymphocytes from bovine leukosis. In the purified C-particle fraction a DNA-polymerase activity was detected. Using several synthetic RNA-or DNA-homopolymers and 70S Friend virus RNA the template response of this bovine leukosis cell particle DNA polymerase was compared with those of feline leukaemia virus DNA polymerase and DNA polymerase from normal bovine lymphocytes. The DNA polymerase detected in the viral preparation of bovine leukosis is suggested to be an oncorna-virus-specific enzyme.

scholarly journals Human Cytomegalovirus Inhibitor AL18 Also Possesses Activity against Influenza A and B Viruses

2012 ◽  
Vol 56 (11) ◽  
pp. 6009-6013 ◽  
Author(s):  
Giulia Muratore ◽  
Beatrice Mercorelli ◽  
Laura Goracci ◽  
Gabriele Cruciani ◽  
Paul Digard ◽  
...  
Keyword(s):  
Influenza A Virus ◽  
Dna Polymerase ◽  
Human Cytomegalovirus ◽  
Influenza A ◽  
Molecular Model ◽  
Polymerase Activity

ABSTRACTAL18, an inhibitor of human cytomegalovirus DNA polymerase, was serendipitously found to also block the interaction between the PB1 and PA polymerase subunits of influenza A virus. Furthermore, AL18 effectively inhibited influenza A virus polymerase activity and the overall replication of influenza A and B viruses. A molecular model to explain the binding of AL18 to both cytomegalovirus and influenza targets is proposed. Thus, AL18 represents an interesting lead for the development of new antivirals.

DNA polymerase activity of cultured normal and leukemic lymphocytes *1Response to phytohemagglutinin

1969 ◽  
Vol 57 (2-3) ◽  
pp. 257-262 ◽  
Author(s):  
Y RABINOWITZ ◽  
I MCCLUSKEY ◽  
P WONG ◽  
B WILHITE
Keyword(s):  
Dna Polymerase ◽  
Polymerase Activity

DNA Polymerase Activity in Human Serum: Studies with Australia Antigen

1973 ◽  
Vol 143 (2) ◽  
pp. 519-525 ◽  
Author(s):  
L. A. Loeb ◽  
R. O. Williams ◽  
A. I. Sutnick ◽  
A. O'Connell ◽  
I. Millman
Keyword(s):  
Human Serum ◽  
Dna Polymerase ◽  
Polymerase Activity ◽  
Australia Antigen
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